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Aliases for MIR631 Gene

Subcategory (RNA class) for MIR631 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR631 Gene

  • MicroRNA 631 2 3 5
  • Hsa-Mir-631 3
  • MIRN631 3

External Ids for MIR631 Gene

Previous HGNC Symbols for MIR631 Gene

  • MIRN631

Previous GeneCards Identifiers for MIR631 Gene

  • GC15M073434
  • GC15M075645

Summaries for MIR631 Gene

Entrez Gene Summary for MIR631 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR631 Gene

MIR631 (MicroRNA 631) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Lysosomal oligosaccharide catabolism and Glycosaminoglycan metabolism.

fRNAdb sequence ontologies for MIR631 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR631 Gene

Genomics for MIR631 Gene

Regulatory Elements for MIR631 Gene

Enhancers for MIR631 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G075323 0.5 ENCODE 42 +29.7 29653 1.1 ZNF316 ZNF362 ZNF600 ZNF18 MIR631 SNUPN MAN2C1 ANP32BP1 COMMD4
GH15G075693 1.5 Ensembl ENCODE dbSUPER 13.5 -342.2 -342218 5.4 ATF1 ARNT SIN3A TCF12 GLIS2 GATA2 ZNF143 FOS JUNB NCOA1 MIR631 ENSG00000261043 SNX33 SCAMP5 ENSG00000203392 CSPG4
GH15G075658 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.4 -311.0 -311036 12.0 FOXA2 ARID4B SIN3A ZNF48 TCF12 ZNF121 FOS SP3 PPARG SMARCB1 SNX33 MIR631 MAN2C1 ENSG00000260274 ENSG00000260892 GC15P075650
GH15G075716 1.3 Ensembl ENCODE dbSUPER 12 -364.1 -364092 2.8 ESRRA MXI1 JUN MAX SIN3A RFX5 FOSL1 GATA3 ZNF600 FOS MIR631 MAN2C1 LOC101929408 COMMD4 GC15P075718 CSPG4
GH15G075699 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 -348.2 -348216 5.4 HDGF SCRT1 MAZ MTA2 BHLHE40 KLF17 GATAD2B EBF1 DPF2 ZNF398 ENSG00000261043 MIR631 MAN2C1 ODF3L1 CSPG4 SNX33 SIN3A C15orf39 ENSG00000203392
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR631 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR631 Gene

Chromosome:
15
Start:
75,353,611 bp from pter
End:
75,353,685 bp from pter
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR631 Gene

Genes around MIR631 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR631 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR631 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR631 Gene

ORGUL Member Location for MIR631 Gene

ORGUL Member Location for MIR631 gene

Proteins for MIR631 Gene

Post-translational modifications for MIR631 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR631 Gene

Domains & Families for MIR631 Gene

Gene Families for MIR631 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR631: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR631 Gene

Function for MIR631 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR631 Gene

Localization for MIR631 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR631 Gene

Pathways & Interactions for MIR631 Gene

genes like me logo Genes that share pathways with MIR631: view

Pathways by source for MIR631 Gene

Interacting Proteins for MIR631 Gene

Gene Ontology (GO) - Biological Process for MIR631 Gene

None

No data available for SIGNOR curated interactions for MIR631 Gene

Drugs & Compounds for MIR631 Gene

No Compound Related Data Available

Transcripts for MIR631 Gene

mRNA/cDNA for MIR631 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR631 Gene

No ASD Table

Relevant External Links for MIR631 Gene

GeneLoc Exon Structure for
MIR631
ECgene alternative splicing isoforms for
MIR631

Expression for MIR631 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR631 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR631 Gene:

MIR631
genes like me logo Genes that share expression patterns with MIR631: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR631 Gene

Orthologs for MIR631 Gene

Evolution for MIR631 Gene

ENSEMBL:
Gene Tree for MIR631 (if available)
TreeFam:
Gene Tree for MIR631 (if available)

No data available for Orthologs for MIR631 Gene

Paralogs for MIR631 Gene

No data available for Paralogs for MIR631 Gene

Variants for MIR631 Gene

Sequence variations from dbSNP and Humsavar for MIR631 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000890518 -- 75,355,155(+) CCCTG(C/G)ACAAC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1001128493 -- 75,354,867(+) GGATG(A/G)GATGG intron-variant, upstream-variant-2KB
rs1001424088 -- 75,353,534(+) CAAGG(A/C)TTCTT intron-variant, downstream-variant-500B
rs1002122012 -- 75,354,141(+) CTAAG(A/G)GAGAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1003984270 -- 75,355,395(+) GCCTC(C/T)GCAAG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR631 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
esv2749894 CNV deletion 23290073
nsv1116463 OTHER inversion 24896259
nsv1615 CNV insertion 18451855
nsv951996 CNV deletion 24416366

Relevant External Links for MIR631 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR631

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR631 Gene

Disorders for MIR631 Gene

Relevant External Links for MIR631

Genetic Association Database (GAD)
MIR631
Human Genome Epidemiology (HuGE) Navigator
MIR631
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR631

No disorders were found for MIR631 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR631 Gene

Publications for MIR631 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  2. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  3. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  4. hsa-miR-631 resensitizes bortezomib-resistant multiple myeloma cell lines by inhibiting UbcH10. (PMID: 28000886) Xi H. … Zhao L.M. (Oncol. Rep. 2017) 3 64
  5. MiR-631/ZAP70: A novel axis in the migration and invasion of prostate cancer cells. (PMID: 26620225) Fu D. … Jiang H. (Biochem. Biophys. Res. Commun. 2016) 3 64

Products for MIR631 Gene

Sources for MIR631 Gene

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