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Aliases for MIR631 Gene

Subcategory (RNA class) for MIR631 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR631 Gene

  • MicroRNA 631 2 3
  • Mannosidase Alpha Class 2C Member 1 4 5
  • EC 3.2.1.24 4 61
  • MAN2C1 4 5
  • Alpha-D-Mannoside Mannohydrolase 4
  • Alpha Mannosidase 6A8B 4
  • Hsa-Mir-631 3
  • MIRN631 3
  • MANA1 4
  • MANA 4

External Ids for MIR631 Gene

Previous HGNC Symbols for MIR631 Gene

  • MIRN631

Previous GeneCards Identifiers for MIR631 Gene

  • GC15M073434
  • GC15M075645

Summaries for MIR631 Gene

Entrez Gene Summary for MIR631 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR631 Gene

MIR631 (MicroRNA 631) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Lysosomal oligosaccharide catabolism.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR631 Gene

Genomics for MIR631 Gene

Regulatory Elements for MIR631 Gene

Enhancers for MIR631 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F075693 1.6 FANTOM5 Ensembl ENCODE 13.5 -330.4 -330371 12.0 HDGF ATF1 ARNT SIN3A GLIS2 GATA2 ZNF143 FOS NCOA1 REST LOC441728 DNM1P49 LOC105370902 ENSG00000261232 MIR631 MIR4313 MAN2C1 SNX33 ODF3L1 SCAMP5
GH15F075323 0.5 ENCODE 42 +44.6 44598 1.1 ZNF316 ZNF362 ZNF600 ZNF18 MIR631 SNUPN MAN2C1 ANP32BP1 COMMD4
GH15F075658 1.6 FANTOM5 Ensembl ENCODE 8.4 -296.1 -296091 12.0 ARID4B SIN3A ZNF48 ZNF121 FOS SP3 PPARG SMARCB1 ZNF623 SSRP1 SNX33 MIR631 MAN2C1 ENSG00000260274 ENSG00000260892 GC15P075650
GH15F075637 1.2 ENCODE 10.8 -270.9 -270858 4.5 HDGF CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MAN2C1 SNUPN LOC441728 DNM1P49 LOC105370902 ENSG00000261232 ENSG00000203392 CSPG4 ENSG00000260274 MIR631
GH15F075307 1.1 Ensembl ENCODE 11.3 +60.4 60397 0.5 ELF3 CTCF KLF1 TFAP4 KLF17 ARID4B MAX ZNF2 RAD21 RFX5 MIR631 PIRC69 DNM1P34
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR631 on UCSC Golden Path with GeneCards custom track

Promoters for MIR631 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000022237 30 1601 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for MIR631 Gene

Chromosome:
15
Start:
75,353,611 bp from pter
End:
75,368,630 bp from pter
Size:
15,020 bases
Orientation:
Minus strand

Genomic View for MIR631 Gene

Genes around MIR631 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR631 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR631 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR631 Gene

Proteins for MIR631 Gene

  • Protein details for MIR631 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTJ4-MA2C1_HUMAN
    Recommended name:
    Alpha-mannosidase 2C1
    Protein Accession:
    Q9NTJ4
    Secondary Accessions:
    • H3BMX2
    • H3BQY8
    • H3BUT6
    • Q13358
    • Q68EM8
    • Q9UL64

    Protein attributes for MIR631 Gene

    Size:
    1040 amino acids
    Molecular mass:
    115835 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC00190.2; Type=Frameshift; Positions=1013; Evidence={ECO:0000305}; Sequence=AAC00568.1; Type=Frameshift; Positions=1013; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR631 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR631 Gene

Selected DME Specific Peptides for MIR631 Gene

Q9NTJ4:
  • RPTHYNTSWD
  • KFLKVEFP
  • LPDTFGYSAQLPQ
  • CHIDTAWLWPF
  • GGTWVEMDGNLPSGE

Post-translational modifications for MIR631 Gene

  • Ubiquitination at Lys 750
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR631 Gene

Gene Families for MIR631 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NTJ4

UniProtKB/Swiss-Prot:

MA2C1_HUMAN :
  • Belongs to the glycosyl hydrolase 38 family.
Family:
  • Belongs to the glycosyl hydrolase 38 family.
genes like me logo Genes that share domains with MIR631: view

No data available for Suggested Antigen Peptide Sequences for MIR631 Gene

Function for MIR631 Gene

Molecular function for MIR631 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Enzyme Numbers (IUBMB) for MIR631 Gene

Gene Ontology (GO) - Molecular Function for MIR631 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0004559 alpha-mannosidase activity TAS --
GO:0008270 zinc ion binding IEA --
GO:0015923 mannosidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MIR631: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR631 Gene

Localization for MIR631 Gene

Gene Ontology (GO) - Cellular Components for MIR631 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005773 vacuole IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR631: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for MIR631 Gene

Pathways & Interactions for MIR631 Gene

genes like me logo Genes that share pathways with MIR631: view

Pathways by source for MIR631 Gene

Gene Ontology (GO) - Biological Process for MIR631 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006013 mannose metabolic process IEA --
GO:0006517 protein deglycosylation IBA --
GO:0008152 metabolic process IEA --
GO:0009313 oligosaccharide catabolic process TAS --
genes like me logo Genes that share ontologies with MIR631: view

No data available for SIGNOR curated interactions for MIR631 Gene

Transcripts for MIR631 Gene

mRNA/cDNA for MIR631 Gene

(46) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR631 Gene

No ASD Table

Relevant External Links for MIR631 Gene

GeneLoc Exon Structure for
MIR631
ECgene alternative splicing isoforms for
MIR631

Expression for MIR631 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR631 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR631 Gene:

MIR631
genes like me logo Genes that share expression patterns with MIR631: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR631 Gene

Orthologs for MIR631 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR631 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAN2C1 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAN2C1 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAN2C1 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Man2c1 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MAN2C1 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MAN2C1 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAN2C1 35
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii man2c1 35
  • 62 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AMS1 35 37
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Species where no ortholog for MIR631 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR631 Gene

ENSEMBL:
Gene Tree for MIR631 (if available)
TreeFam:
Gene Tree for MIR631 (if available)

Paralogs for MIR631 Gene

No data available for Paralogs for MIR631 Gene

Variants for MIR631 Gene

Sequence variations from dbSNP and Humsavar for MIR631 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10653888 -- 75,353,224(+) TTTAT(-/ACAC/ACACACAC)ACACA intron-variant, downstream-variant-500B
rs111431272 -- 75,353,764(+) GAGAG(A/C)GGGGA intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense
rs112012663 -- 75,353,882(+) ACTGT(C/T)CACAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs11630521 -- 75,353,197(+) ACAGG(C/T)AGGAC intron-variant, downstream-variant-500B
rs138644949 -- 75,354,443(+) GTCCC(A/G)CAAAA nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR631 Gene

Variant ID Type Subtype PubMed ID
nsv951996 CNV deletion 24416366
nsv1615 CNV insertion 18451855
nsv1116463 OTHER inversion 24896259
esv2749894 CNV deletion 23290073
dgv2621n100 CNV gain 25217958

Relevant External Links for MIR631 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR631

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR631 Gene

Disorders for MIR631 Gene

Relevant External Links for MIR631

Genetic Association Database (GAD)
MIR631
Human Genome Epidemiology (HuGE) Navigator
MIR631
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR631

No disorders were found for MIR631 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR631 Gene

Publications for MIR631 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 46 64
  2. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 46 64
  3. MiR-631/ZAP70: A novel axis in the migration and invasion of prostate cancer cells. (PMID: 26620225) Fu D. … Jiang H. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR631 Gene

Sources for MIR631 Gene

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