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Aliases for MIR630 Gene

Subcategory (RNA class) for MIR630 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR630 Gene

  • MicroRNA 630 2 3
  • Hsa-Mir-630 3
  • MIRN630 3

External Ids for MIR630 Gene

ORGUL Members for MIR630 Gene

Previous Symbols for MIR630 Gene

  • MIRN630

Summaries for MIR630 Gene

Entrez Gene Summary for MIR630 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR630 Gene

MIR630 (MicroRNA 630) is a RNA Gene, and belongs to miRNA RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR630 Gene

Genomics for MIR630 Gene

Genomic Location for MIR630 Gene

Start:
72,587,217 bp from pter
End:
72,587,313 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR630 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR630 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR630 Gene

No data available for Regulatory Elements for MIR630 Gene

Proteins for MIR630 Gene

Post-translational modifications for MIR630 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR630 Gene

Domains for MIR630 Gene

Gene Families for MIR630 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR630: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR630 Gene

Function for MIR630 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR630 Gene

Localization for MIR630 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR630 Gene

Pathways for MIR630 Gene

SuperPathways for MIR630 Gene

No Data Available

Interacting Proteins for MIR630 Gene

Gene Ontology (GO) - Biological Process for MIR630 Gene

None

No data available for Pathways by source for MIR630 Gene

Transcripts for MIR630 Gene

mRNA/cDNA for MIR630 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR630 Gene

No ASD Table

Relevant External Links for MIR630 Gene

GeneLoc Exon Structure for
MIR630
ECgene alternative splicing isoforms for
MIR630

Expression for MIR630 Gene

mRNA expression in normal human tissues for MIR630 Gene

genes like me logo Genes that share expressions with MIR630: view

Orthologs for MIR630 Gene

Evolution for MIR630 Gene

ENSEMBL:
Gene Tree for MIR630 (if available)
TreeFam:
Gene Tree for MIR630 (if available)

No data available for Orthologs for MIR630 Gene

Paralogs for MIR630 Gene

No data available for Paralogs for MIR630 Gene

Variants for MIR630 Gene

Sequence variations from dbSNP and Humsavar for MIR630 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs56690734 -- 72,587,313(+) TATAT(-/TGT/TTG)TGTAC downstream-variant-500B
rs76528369 -- 72,587,317(+) RTTGT(A/T)CTTTT downstream-variant-500B
rs79363602 -- 72,587,315(+) TRTTG(-/TGN)TWCTT downstream-variant-500B
rs113700837 -- 72,587,314(+) ATATT(-/GTT/TGT)GTACT downstream-variant-500B
rs113971639 -- 72,587,312(+) ACTAT(A/G)TTGTA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR630 Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914
nsv483057 CNV Loss 15286789

Relevant External Links for MIR630 Gene

HapMap Linkage Disequilibrium report
MIR630

Disorders for MIR630 Gene

No disorders were found for MIR630 Gene.

No data available for UniProtKB/Swiss-Prot for MIR630 Gene

Publications for MIR630 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. (PMID: 23675407) Farhana L. … Fontana J.A. (PLoS ONE 2013) 3
  4. miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer. (PMID: 24655723) Corcoran C. … O'Driscoll L. (Mol. Cancer 2014) 3
  5. E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells. (PMID: 24909689) Cao J.X. … Ni J.H. (Biochem. Biophys. Res. Commun. 2014) 3

Products for MIR630 Gene

Sources for MIR630 Gene

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