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Aliases for MIR630 Gene

Subcategory (RNA class) for MIR630 Gene


Quality Score for this RNA gene is


Aliases for MIR630 Gene

  • MicroRNA 630 2 3
  • Hsa-Mir-630 3
  • MIRN630 3

External Ids for MIR630 Gene

ORGUL Members for MIR630 Gene

Previous HGNC Symbols for MIR630 Gene

  • MIRN630

Previous GeneCards Identifiers for MIR630 Gene

  • GC15P070667
  • GC15P072879

Summaries for MIR630 Gene

Entrez Gene Summary for MIR630 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR630 Gene

MIR630 (MicroRNA 630) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR630 Gene

Genomics for MIR630 Gene

Genomic Location for MIR630 Gene

72,587,217 bp from pter
72,587,313 bp from pter
97 bases
Plus strand

Genomic View for MIR630 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR630 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR630 Gene

No data available for Regulatory Elements for MIR630 Gene

Proteins for MIR630 Gene

Post-translational modifications for MIR630 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR630 Gene

Domains for MIR630 Gene

Gene Families for MIR630 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR630: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR630 Gene

Function for MIR630 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR630 Gene

Localization for MIR630 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR630 Gene

Pathways for MIR630 Gene

SuperPathways for MIR630 Gene

No Data Available

Interacting Proteins for MIR630 Gene

Gene Ontology (GO) - Biological Process for MIR630 Gene


No data available for Pathways by source for MIR630 Gene

Transcripts for MIR630 Gene

mRNA/cDNA for MIR630 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR630 Gene

No ASD Table

Relevant External Links for MIR630 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR630 Gene

mRNA expression in normal human tissues for MIR630 Gene

genes like me logo Genes that share expressions with MIR630: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR630 Gene

Orthologs for MIR630 Gene

Evolution for MIR630 Gene

Gene Tree for MIR630 (if available)
Gene Tree for MIR630 (if available)

No data available for Orthologs for MIR630 Gene

Paralogs for MIR630 Gene

No data available for Paralogs for MIR630 Gene

Variants for MIR630 Gene

Sequence variations from dbSNP and Humsavar for MIR630 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs577920571 -- 72,587,675(+) TCAGA(C/T)TTTTC downstream-variant-500B
rs577079814 -- 72,587,542(+) GAAAT(G/T)GTTAC downstream-variant-500B
rs572784411 -- 72,587,757(+) TCAAA(G/T)AGCCA downstream-variant-500B
rs567547183 -- 72,587,477(+) TTTGC(A/C)GTTGT downstream-variant-500B
rs566826819 -- 72,587,403(+) CATTT(A/G)TTGCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR630 Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914
nsv483057 CNV Loss 15286789

Relevant External Links for MIR630 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR630 Gene

Disorders for MIR630 Gene

No disorders were found for MIR630 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR630 Gene

Publications for MIR630 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. (PMID: 23675407) Farhana L. … Fontana J.A. (PLoS ONE 2013) 3
  4. miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer. (PMID: 24655723) Corcoran C. … O'Driscoll L. (Mol. Cancer 2014) 3
  5. E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells. (PMID: 24909689) Cao J.X. … Ni J.H. (Biochem. Biophys. Res. Commun. 2014) 3

Products for MIR630 Gene

Sources for MIR630 Gene

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