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Aliases for MIR630 Gene

Subcategory (RNA class) for MIR630 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR630 Gene

  • MicroRNA 630 2 3
  • ARIH1 4 5
  • Ubiquitin-Conjugating Enzyme E2-Binding Protein 1 4
  • Ariadne RBR E3 Ubiquitin Protein Ligase 1 5
  • Protein Ariadne-1 Homolog 4
  • UbcM4-Interacting Protein 4
  • UbcH7-Binding Protein 4
  • Monocyte Protein 6 4
  • Hsa-Mir-630 3
  • EC 2.3.2.- 4
  • UBCH7BP 4
  • MIRN630 3
  • H7-AP2 4
  • ARI-1 4
  • HHARI 4
  • MOP-6 4
  • MOP6 4
  • ARI 4

External Ids for MIR630 Gene

Previous HGNC Symbols for MIR630 Gene

  • MIRN630

Previous GeneCards Identifiers for MIR630 Gene

  • GC15P070667
  • GC15P072879
  • GC15P072587

Summaries for MIR630 Gene

Entrez Gene Summary for MIR630 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR630 Gene

MIR630 (MicroRNA 630) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is ARIH2.

UniProtKB/Swiss-Prot for MIR630 Gene

  • E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR630 Gene

Genomics for MIR630 Gene

Regulatory Elements for MIR630 Gene

Enhancers for MIR630 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072365 0.9 Ensembl ENCODE 11.1 -106.0 -106025 5.0 TBL1XR1 MTA2 IKZF1 EED TCF7 JUNB ETV6 CREM SPI1 ARIH1 MIR630 HEXA ENSG00000260729 CELF6
GH15F072615 0.8 Ensembl ENCODE 11.2 +141.7 141745 0.3 ZNF121 CTCF PATZ1 IRF1 ZNF600 KDM1A MIR630 ENSG00000260672 ENSG00000259783
GH15F072604 0.7 FANTOM5 ENCODE 12.2 +130.7 130676 0.2 TCF7L2 TMEM202 SENP8 MIR630 HEXA MYO9A ENSG00000278313 LOC100420930
GH15F072616 0.7 ENCODE 11.2 +141.3 141252 0.5 ZBTB8A ZIC2 ZNF121 ZNF335 ZNF692 SMARCA4 ZBTB48 PATZ1 ZNF600 IRF1 MIR630 ENSG00000260672 GC15P072623
GH15F072342 0.6 ENCODE 11.2 -131.7 -131732 0.2 CTCF GATA3 ZNF654 SMC3 ZBTB33 RAD21 HEXA RPL12P35 ARIH1 MIR630 CELF6 ENSG00000260729
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR630 on UCSC Golden Path with GeneCards custom track

Promoters for MIR630 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000410995 674 3201 CREB3L1 MLX YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263

Genomic Location for MIR630 Gene

Chromosome:
15
Start:
72,474,326 bp from pter
End:
72,602,985 bp from pter
Size:
128,660 bases
Orientation:
Plus strand

Genomic View for MIR630 Gene

Genes around MIR630 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR630 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR630 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR630 Gene

Proteins for MIR630 Gene

  • Protein details for MIR630 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X5-ARI1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ARIH1
    Protein Accession:
    Q9Y4X5
    Secondary Accessions:
    • B2R6U3
    • O76026
    • Q9H3T6
    • Q9UEN0
    • Q9UP39

    Protein attributes for MIR630 Gene

    Size:
    557 amino acids
    Molecular mass:
    64118 Da
    Quaternary structure:
    • Interacts (via the first RING-type zinc finger) with UBE2L3 (PubMed:11278816, PubMed:21532592, PubMed:24076655, PubMed:23707686). Associates with cullin-RING ubiquitin ligase (CRL) complexes containing CUL1, CUL2 and CUL3 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL1 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL2 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL3 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL4A (PubMed:24076655).
    • Interacts (via the first RING-type zinc finger) with UBE2L3 (PubMed:11278816, PubMed:21532592, PubMed:24076655, PubMed:23707686). Associates with cullin-RING ubiquitin ligase (CRL) complexes containing CUL1, CUL2 and CUL3 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL1 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL2 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL3 (PubMed:24076655, PubMed:27565346). Interacts with neddylated CUL4A (PubMed:24076655).

    Three dimensional structures from OCA and Proteopedia for MIR630 Gene

neXtProt entry for MIR630 Gene

Post-translational modifications for MIR630 Gene

  • Ubiquitination at Lys 144, Lys 156, and Lys 286
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR630 Gene

No data available for DME Specific Peptides for MIR630 Gene

Domains & Families for MIR630 Gene

Gene Families for MIR630 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4X5

UniProtKB/Swiss-Prot:

ARI1_HUMAN :
  • Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger (PubMed:21532592, PubMed:23707686). The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate (PubMed:21532592, PubMed:23707686).
  • Belongs to the RBR family. Ariadne subfamily.
  • Contains 1 IBR-type zinc finger.
Domain:
  • Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING-type zinc finger, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved active site Cys residue in the second RING-type zinc finger (PubMed:21532592, PubMed:23707686). The active site probably forms a thioester intermediate with ubiquitin taken from the active-site cysteine of the E2 before ultimately transferring it to a Lys residue on the substrate (PubMed:21532592, PubMed:23707686).
  • The Ariadne domain inhibits activity by masking the second RING-type zinc finger that contains the active site (PubMed:23707686).
Family:
  • Belongs to the RBR family. Ariadne subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with MIR630: view

No data available for Suggested Antigen Peptide Sequences for MIR630 Gene

Function for MIR630 Gene

Molecular function for MIR630 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity (PubMed:23707686). Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1 (PubMed:24076655, PubMed:27565346).
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916).
UniProtKB/Swiss-Prot Induction:
Up-regulated following DNA damage (PubMed:25624349).

Enzyme Numbers (IUBMB) for MIR630 Gene

Gene Ontology (GO) - Molecular Function for MIR630 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI --
GO:0008270 zinc ion binding IDA --
GO:0016874 ligase activity IEA --
GO:0019787 ubiquitin-like protein transferase activity TAS --
genes like me logo Genes that share ontologies with MIR630: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR630 Gene

Localization for MIR630 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR630 Gene

Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Mainly cytoplasmic (PubMed:11278816). Present in Lewy body (PubMed:21590270). {ECO:0000269 PubMed:11278816, ECO:0000269 PubMed:21590270}.

Gene Ontology (GO) - Cellular Components for MIR630 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IDA --
GO:0019005 SCF ubiquitin ligase complex IDA --
GO:0031462 Cul2-RING ubiquitin ligase complex IDA --
genes like me logo Genes that share ontologies with MIR630: view

No data available for Subcellular locations from COMPARTMENTS for MIR630 Gene

Pathways & Interactions for MIR630 Gene

genes like me logo Genes that share pathways with MIR630: view

UniProtKB/Swiss-Prot Q9Y4X5-ARI1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for MIR630 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006511 ubiquitin-dependent protein catabolic process TAS --
GO:0016567 protein ubiquitination IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with MIR630: view

No data available for SIGNOR curated interactions for MIR630 Gene

Transcripts for MIR630 Gene

mRNA/cDNA for MIR630 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR630 Gene

No ASD Table

Relevant External Links for MIR630 Gene

GeneLoc Exon Structure for
MIR630
ECgene alternative splicing isoforms for
MIR630

Expression for MIR630 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR630 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR630 Gene:

MIR630

mRNA Expression by UniProt/SwissProt for MIR630 Gene:

Q9Y4X5-ARI1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with MIR630: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR630 Gene

Orthologs for MIR630 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR630 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARIH1 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARIH1 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARIH1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARIH1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARIH1 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arih1 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARIH1 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARIH1 35
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arih1 35
  • 95 (a)
OneToMany
arih1l 35
  • 92 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ari-1 35
  • 68 (a)
OneToMany
CG12362 35
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ari-1 35
  • 53 (a)
OneToMany
C27A12.6 35
  • 48 (a)
OneToMany
C27A12.7 35
  • 48 (a)
OneToMany
tag-349 35
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 28 (a)
OneToMany
HEL1 37
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11309 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR630 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR630 Gene

ENSEMBL:
Gene Tree for MIR630 (if available)
TreeFam:
Gene Tree for MIR630 (if available)

Paralogs for MIR630 Gene

Paralogs for MIR630 Gene

genes like me logo Genes that share paralogs with MIR630: view

Variants for MIR630 Gene

Sequence variations from dbSNP and Humsavar for MIR630 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs112478355 -- 72,585,968(+) TCATT(A/G)TCTTT upstream-variant-2KB, utr-variant-3-prime
rs113700837 -- 72,587,314(+) ATATT(-/GTT/TGT)GTACT downstream-variant-500B
rs113971639 -- 72,587,312(+) ACTAT(A/G)TTGTA nc-transcript-variant
rs115691230 -- 72,585,396(+) ATATA(A/C)ATTAA upstream-variant-2KB, utr-variant-3-prime
rs11629713 -- 72,587,044(+) ATTTA(A/T)TTTAC downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR630 Gene

Variant ID Type Subtype PubMed ID
nsv483057 CNV loss 15286789
nsv428307 CNV gain 18775914
esv2760039 CNV gain+loss 17122850

Relevant External Links for MIR630 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR630

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR630 Gene

Disorders for MIR630 Gene

Relevant External Links for MIR630

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR630

No disorders were found for MIR630 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR630 Gene

Publications for MIR630 Gene

  1. MiR-630 suppresses breast cancer progression by targeting metadherin. (PMID: 26595523) Zhou C.X. … Zhao Q. (Oncotarget 2016) 3 64
  2. Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. (PMID: 27565346) Scott D.C. … Schulman B.A. (Cell 2016) 4 64
  3. miR-630 overexpression in hepatocellular carcinoma tissues is positively correlated with alpha-fetoprotein. (PMID: 25731670) Zhang J.W. … Jiang N. (Med. Sci. Monit. 2015) 3 64
  4. Novel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer. (PMID: 26263387) Zhang Y. … Li G. (PLoS ONE 2015) 3 64
  5. Downregulation of microRNA-630 inhibits cell proliferation and invasion and enhances chemosensitivity in human ovarian carcinoma. (PMID: 26345808) Zou Y.T. … Li P.L. (Genet. Mol. Res. 2015) 3 64

Products for MIR630 Gene

Sources for MIR630 Gene

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