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Aliases for MIR630 Gene

Subcategory (RNA class) for MIR630 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR630 Gene

  • MicroRNA 630 2 3 5
  • Hsa-Mir-630 3
  • MIRN630 3

External Ids for MIR630 Gene

ORGUL Members for MIR630 Gene

Previous HGNC Symbols for MIR630 Gene

  • MIRN630

Previous GeneCards Identifiers for MIR630 Gene

  • GC15P070667
  • GC15P072879

Summaries for MIR630 Gene

Entrez Gene Summary for MIR630 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR630 Gene

MIR630 (MicroRNA 630) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR630 Gene

Genomics for MIR630 Gene

Genomic Location for MIR630 Gene

Chromosome:
15
Start:
72,587,217 bp from pter
End:
72,587,313 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR630 Gene

Genes around MIR630 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR630 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR630 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR630 Gene

No data available for Regulatory Elements for MIR630 Gene

Proteins for MIR630 Gene

Post-translational modifications for MIR630 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR630 Gene

Domains & Families for MIR630 Gene

Gene Families for MIR630 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR630: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR630 Gene

Function for MIR630 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR630 Gene

Localization for MIR630 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR630 Gene

Pathways & Interactions for MIR630 Gene

SuperPathways for MIR630 Gene

No Data Available

Interacting Proteins for MIR630 Gene

Gene Ontology (GO) - Biological Process for MIR630 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR630 Gene

Drugs & Compounds for MIR630 Gene

No Compound Related Data Available

Transcripts for MIR630 Gene

mRNA/cDNA for MIR630 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR630 Gene

No ASD Table

Relevant External Links for MIR630 Gene

GeneLoc Exon Structure for
MIR630
ECgene alternative splicing isoforms for
MIR630

Expression for MIR630 Gene

mRNA expression in normal human tissues for MIR630 Gene

genes like me logo Genes that share expression patterns with MIR630: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR630 Gene

Orthologs for MIR630 Gene

Evolution for MIR630 Gene

ENSEMBL:
Gene Tree for MIR630 (if available)
TreeFam:
Gene Tree for MIR630 (if available)

No data available for Orthologs for MIR630 Gene

Paralogs for MIR630 Gene

No data available for Paralogs for MIR630 Gene

Variants for MIR630 Gene

Sequence variations from dbSNP and Humsavar for MIR630 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs56690734 -- 72,587,313(+) TATAT(-/TGT/TTG)TGTAC downstream-variant-500B
rs79363602 -- 72,587,315(+) TRTTG(-/TGN/TTA)TWCTT downstream-variant-500B
rs113700837 -- 72,587,314(+) ATATT(-/GTT/TGT)GTACT downstream-variant-500B
rs113971639 -- 72,587,312(+) ACTAT(A/G)TTGTA nc-transcript-variant
rs139334001 -- 72,587,312(+) CTATA(-/TTG)TTGTA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR630 Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914
nsv483057 CNV Loss 15286789

Relevant External Links for MIR630 Gene

HapMap Linkage Disequilibrium report
MIR630

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR630 Gene

Disorders for MIR630 Gene

Relevant External Links for MIR630

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR630

No disorders were found for MIR630 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR630 Gene

Publications for MIR630 Gene

  1. miR-630 overexpression in hepatocellular carcinoma tissues is positively correlated with alpha-fetoprotein. (PMID: 25731670) Zhang J.W. … Jiang N. (Med. Sci. Monit. 2015) 3 67
  2. MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells. (PMID: 25255219) Cao J.X. … Ni J.H. (Cell Death Dis 2014) 3
  3. MicroRNA-630 is a prognostic marker for patients with colorectal cancer. (PMID: 24981248) Chu D. … Ji G. (Tumour Biol. 2014) 3
  4. E2F1-regulated DROSHA promotes miR-630 biosynthesis in cisplatin-exposed cancer cells. (PMID: 24909689) Cao J.X. … Ni J.H. (Biochem. Biophys. Res. Commun. 2014) 3
  5. miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer. (PMID: 24655723) Corcoran C. … O'Driscoll L. (Mol. Cancer 2014) 3

Products for MIR630 Gene

Sources for MIR630 Gene

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