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Aliases for MIR628 Gene

Subcategory (RNA class) for MIR628 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR628 Gene

  • MicroRNA 628 2 3 5
  • Hsa-Mir-628 3
  • Mir-628 3
  • MIRN628 3

External Ids for MIR628 Gene

Previous HGNC Symbols for MIR628 Gene

  • MIRN628

Previous GeneCards Identifiers for MIR628 Gene

  • GC15M053453
  • GC15M055665
  • GC15M055480
  • GC15M055481

Summaries for MIR628 Gene

Entrez Gene Summary for MIR628 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR628 Gene

MIR628 (MicroRNA 628) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR628 Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR628

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR628 Gene

Genomics for MIR628 Gene

Regulatory Elements for MIR628 Gene

Enhancers for MIR628 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G055396 0.9 ENCODE 13.1 -24.1 -24075 0.9 HDAC1 TBP CBX3 ARNT NFRKB CHAMP1 TCF12 GTF3C2 GATA2 EGR1 MIR628 C15orf65 PIGB DNAAF4 GC15M056539
GH15G055394 0.5 ENCODE 11.5 -21.8 -21844 0.2 PRDM6 CEBPB TRIM24 ZNF843 MIR628 C15orf65 DNAAF4 GC15M056539
GH15G055344 0.4 ENCODE 12 +28.6 28597 0.2 TEAD4 PRDM10 MIR628 ENSG00000277548 ENSG00000274765
GH15G055395 0.4 Ensembl 11.5 -22.1 -22067 0.2 CEBPB TRIM24 MIR628 GC15M056539
GH15G055388 0.6 ENCODE 0.4 -16.2 -16235 1.3 JUND JUN CEBPB FOS IRF1 EP300 TCF7L2 C15orf65 PIGB GC15M056539 MIR628
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR628 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR628 Gene

Chromosome:
15
Start:
55,372,940 bp from pter
End:
55,373,034 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR628 Gene

Genes around MIR628 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR628 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR628 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR628 Gene

ORGUL Member Location for MIR628 Gene

ORGUL Member Location for MIR628 gene

Proteins for MIR628 Gene

Post-translational modifications for MIR628 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR628 Gene

Domains & Families for MIR628 Gene

Gene Families for MIR628 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR628: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR628 Gene

Function for MIR628 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR628 Gene

Localization for MIR628 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR628 Gene

Pathways & Interactions for MIR628 Gene

SuperPathways for MIR628 Gene

No Data Available

Interacting Proteins for MIR628 Gene

Gene Ontology (GO) - Biological Process for MIR628 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR628 Gene

Transcripts for MIR628 Gene

fRNAdb Secondary structures for MIR628 Gene

  • hsa-miR-628-3p_MIMAT0003297_Homo_sapiens_miR-628-3p_mature

mRNA/cDNA for MIR628 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR628 Gene

No ASD Table

Relevant External Links for MIR628 Gene

GeneLoc Exon Structure for
MIR628
ECgene alternative splicing isoforms for
MIR628

Expression for MIR628 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR628 Gene

mRNA differential expression in normal tissues according to GTEx for MIR628 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x7.3), Brain - Cortex (x6.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Anterior cingulate cortex (BA24) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR628 Gene:

MIR628
genes like me logo Genes that share expression patterns with MIR628: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR628 Gene

Orthologs for MIR628 Gene

Evolution for MIR628 Gene

ENSEMBL:
Gene Tree for MIR628 (if available)
TreeFam:
Gene Tree for MIR628 (if available)

No data available for Orthologs for MIR628 Gene

Paralogs for MIR628 Gene

No data available for Paralogs for MIR628 Gene

Variants for MIR628 Gene

Sequence variations from dbSNP and Humsavar for MIR628 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1001572133 -- 55,374,654(+) GAGAC(A/G)GGGTC intron-variant, upstream-variant-2KB
rs1003005959 -- 55,373,670(+) AAAGA(A/G)AGGAA intron-variant, upstream-variant-2KB
rs1003338158 -- 55,374,818(+) ATTAC(A/T)GGCAC intron-variant, upstream-variant-2KB
rs1004449910 -- 55,372,760(+) GGTAA(G/T)TTAAG intron-variant, downstream-variant-500B
rs1004783308 -- 55,374,308(+) AAAAG(-/A)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR628 Gene

Variant ID Type Subtype PubMed ID
esv2761899 CNV gain+loss 21179565
esv3569598 CNV gain 25503493
nsv1043789 CNV gain 25217958
nsv520799 CNV loss 19592680
nsv569523 CNV gain 21841781

Relevant External Links for MIR628 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR628

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR628 Gene

Disorders for MIR628 Gene

Relevant External Links for MIR628

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR628

No disorders were found for MIR628 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR628 Gene

Publications for MIR628 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR-628-3p regulates osteoblast differentiation by targeting RUNX2: Possible role in atrophic non-union. (PMID: 28035362) Chen H. … Tang P. (Int. J. Mol. Med. 2017) 3 64
  3. Dysregulated MicroRNA Expression and Chronic Lung Allograft Rejection in Recipients With Antibodies to Donor HLA. (PMID: 25649290) Xu Z. … Mohanakumar T. (Am. J. Transplant. 2015) 3 64
  4. Circulatory miR-628-5p is downregulated in prostate cancer patients. (PMID: 24477576) Srivastava A. … Kumar D. (Tumour Biol. 2014) 3 64
  5. microRNAs in circulation are altered in response to influenza A virus infection in humans. (PMID: 24116168) Tambyah P.A. … Jeyaseelan K. (PLoS ONE 2013) 3 64

Products for MIR628 Gene

Sources for MIR628 Gene

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