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Aliases for MIR628 Gene

Subcategory (RNA class) for MIR628 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR628 Gene

  • MicroRNA 628 2 3
  • CCPG1 4 5
  • Cell Cycle Progression Restoration Protein 8 4
  • Cell Cycle Progression 1 5
  • Hsa-Mir-628 3
  • KIAA1254 4
  • Mir-628 3
  • MIRN628 3
  • CPR8 4
  • CCP8 4

External Ids for MIR628 Gene

Previous HGNC Symbols for MIR628 Gene

  • MIRN628

Previous GeneCards Identifiers for MIR628 Gene

  • GC15M053453
  • GC15M055665
  • GC15M055372
  • GC15M055480

Summaries for MIR628 Gene

Entrez Gene Summary for MIR628 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR628 Gene

MIR628 (MicroRNA 628) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is PBXIP1.

UniProtKB/Swiss-Prot for MIR628 Gene

  • Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR628 Gene

Genomics for MIR628 Gene

Regulatory Elements for MIR628 Gene

Enhancers for MIR628 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F055344 0.7 Ensembl ENCODE 11.8 +64.1 64109 0.4 TEAD4 PRDM10 MIR628 ENSG00000274765 ENSG00000277548
GH15F055401 1.2 ENCODE 0.8 +3.0 2951 7.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 RSL24D1 PYGO1 DYX1C1 C15orf65 PIGB CCPG1 MIR628 GC15M055985
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR628 on UCSC Golden Path with GeneCards custom track

Promoters for MIR628 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000408268 310 2400 HDGF CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 KLF13

Genomic Location for MIR628 Gene

Chromosome:
15
Start:
55,340,032 bp from pter
End:
55,408,510 bp from pter
Size:
68,479 bases
Orientation:
Minus strand

Genomic View for MIR628 Gene

Genes around MIR628 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR628 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR628 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR628 Gene

Proteins for MIR628 Gene

  • Protein details for MIR628 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULG6-CCPG1_HUMAN
    Recommended name:
    Cell cycle progression protein 1
    Protein Accession:
    Q9ULG6
    Secondary Accessions:
    • A0PJH3
    • A8K9T0
    • O14712
    • Q05DG4
    • Q5U5S7
    • Q8IYV8
    • Q9BY53
    • Q9HA17

    Protein attributes for MIR628 Gene

    Size:
    757 amino acids
    Molecular mass:
    87340 Da
    Quaternary structure:
    • Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).
    • Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).
    SequenceCaution:
    • Sequence=AAB69314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH15203.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH29398.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA86568.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR628 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR628 Gene

Post-translational modifications for MIR628 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR628 Gene

Domains & Families for MIR628 Gene

Gene Families for MIR628 Gene

Protein Domains for MIR628 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9ULG6

UniProtKB/Swiss-Prot:

CCPG1_HUMAN :
  • Belongs to the CCPG1 family.
Family:
  • Belongs to the CCPG1 family.
genes like me logo Genes that share domains with MIR628: view

No data available for Suggested Antigen Peptide Sequences for MIR628 Gene

Function for MIR628 Gene

Molecular function for MIR628 Gene

UniProtKB/Swiss-Prot Function:
Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

Gene Ontology (GO) - Molecular Function for MIR628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR628: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR628 Gene

Localization for MIR628 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR628 Gene

Cytoplasmic granule membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for MIR628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR628: view

No data available for Subcellular locations from COMPARTMENTS for MIR628 Gene

Pathways & Interactions for MIR628 Gene

SuperPathways for MIR628 Gene

No Data Available

Interacting Proteins for MIR628 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403400%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9ULG6-CCPG1_HUMAN ENSP00000403400 for MIR628 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MIR628 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP --
GO:0045787 positive regulation of cell cycle IMP --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with MIR628: view

No data available for Pathways by source and SIGNOR curated interactions for MIR628 Gene

Transcripts for MIR628 Gene

mRNA/cDNA for MIR628 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR628 Gene

No ASD Table

Relevant External Links for MIR628 Gene

GeneLoc Exon Structure for
MIR628
ECgene alternative splicing isoforms for
MIR628

Expression for MIR628 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR628 Gene

mRNA differential expression in normal tissues according to GTEx for MIR628 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x7.3), Brain - Cortex (x6.4), Brain - Nucleus accumbens (basal ganglia) (x5.3), and Brain - Anterior cingulate cortex (BA24) (x4.0).

NURSA nuclear receptor signaling pathways regulating expression of MIR628 Gene:

MIR628
genes like me logo Genes that share expression patterns with MIR628: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR628 Gene

Orthologs for MIR628 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR628 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCPG1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCPG1 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CCPG1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ccpg1 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCPG1 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCPG1 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCPG1 35
  • 42 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PBXIP1 35
  • 43 (a)
OneToMany
Species where no ortholog for MIR628 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR628 Gene

ENSEMBL:
Gene Tree for MIR628 (if available)
TreeFam:
Gene Tree for MIR628 (if available)

Paralogs for MIR628 Gene

Paralogs for MIR628 Gene

genes like me logo Genes that share paralogs with MIR628: view

Variants for MIR628 Gene

Sequence variations from dbSNP and Humsavar for MIR628 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10518810 -- 55,373,308(+) ATGAA(C/T)TCGAA intron-variant, upstream-variant-2KB
rs111722450 -- 55,373,471(+) ACTTA(A/C)AACAA intron-variant, upstream-variant-2KB
rs112498125 -- 55,372,878(+) TCCAA(A/C)CTAAT intron-variant, downstream-variant-500B
rs112813593 -- 55,372,459(+) AGTTC(A/G)AGATC intron-variant, downstream-variant-500B
rs113216902 -- 55,372,467(+) ATCAG(C/T)CTGGC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR628 Gene

Variant ID Type Subtype PubMed ID
esv2761899 CNV gain+loss 21179565
esv3569598 CNV gain 25503493
nsv1043789 CNV gain 25217958
nsv520799 CNV loss 19592680
nsv569523 CNV gain 21841781

Relevant External Links for MIR628 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR628

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR628 Gene

Disorders for MIR628 Gene

Relevant External Links for MIR628

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR628

No disorders were found for MIR628 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR628 Gene

Publications for MIR628 Gene

  1. Dysregulated MicroRNA Expression and Chronic Lung Allograft Rejection in Recipients With Antibodies to Donor HLA. (PMID: 25649290) Xu Z. … Mohanakumar T. (Am. J. Transplant. 2015) 3 64
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  3. Circulatory miR-628-5p is downregulated in prostate cancer patients. (PMID: 24477576) Srivastava A. … Kumar D. (Tumour Biol. 2014) 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. microRNAs in circulation are altered in response to influenza A virus infection in humans. (PMID: 24116168) Tambyah P.A. … Jeyaseelan K. (PLoS ONE 2013) 3 64

Products for MIR628 Gene

Sources for MIR628 Gene

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