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Aliases for MIR627 Gene

Subcategory (RNA class) for MIR627 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR627 Gene

  • MicroRNA 627 2 3 5
  • Hsa-Mir-627 3
  • Mir-627 3
  • MIRN627 3

External Ids for MIR627 Gene

Previous HGNC Symbols for MIR627 Gene

  • MIRN627

Previous GeneCards Identifiers for MIR627 Gene

  • GC15M040280
  • GC15M042491

Summaries for MIR627 Gene

Entrez Gene Summary for MIR627 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR627 Gene

MIR627 (MicroRNA 627) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR627 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR627

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR627 Gene

Genomics for MIR627 Gene

Regulatory Elements for MIR627 Gene

Enhancers for MIR627 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F042171 0.5 FANTOM5 12 +28.4 28355 0.2 IRF1 MIR627 GANC TMEM87A CAPN3 EHD4 PIR49567 PIR62541 GC15M042161
GH15F042158 0.8 Ensembl ENCODE 11.5 +41.1 41101 1.1 HDAC1 ATF1 PKNOX1 CREB3L1 SIN3A GATA2 FOS CREM PAF1 USF2 MIR627 GANC GC15M042161 GC15P042157 PIR62541
GH15F042165 1.1 ENCODE 11.3 +34.4 34429 0.2 POLR2A SIN3A NR2F2 MIR627 VPS39 CAPN3 GC15M042161 PIR49567 PIR62541
GH15F042227 0.2 ENCODE 10.9 -28.5 -28487 1.7 GANC MIR627 TMEM87A LOC105370795
GH15F042257 0.7 FANTOM5 10.6 -57.6 -57646 0.0 ZNF341 GTF2E2 MIR627 CAPN3 PLA2G4E GANC LOC105370795
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR627 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR627 Gene

Chromosome:
15
Start:
42,199,570 bp from pter
End:
42,199,666 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR627 Gene

Genes around MIR627 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR627 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR627 Gene

ORGUL Member Location for MIR627 Gene

ORGUL Member Location for MIR627 gene

Proteins for MIR627 Gene

Post-translational modifications for MIR627 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR627 Gene

Domains & Families for MIR627 Gene

Gene Families for MIR627 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR627: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR627 Gene

Function for MIR627 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR627 Gene

Localization for MIR627 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR627 Gene

Pathways & Interactions for MIR627 Gene

SuperPathways for MIR627 Gene

No Data Available

Interacting Proteins for MIR627 Gene

Gene Ontology (GO) - Biological Process for MIR627 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR627 Gene

Transcripts for MIR627 Gene

fRNAdb Secondary structures for MIR627 Gene

  • hsa-miR-627-5p_MIMAT0003296_Homo_sapiens_miR-627-5p_mature

mRNA/cDNA for MIR627 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR627 Gene

No ASD Table

Relevant External Links for MIR627 Gene

GeneLoc Exon Structure for
MIR627
ECgene alternative splicing isoforms for
MIR627

Expression for MIR627 Gene

mRNA expression in normal human tissues for MIR627 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR627 Gene:

MIR627
genes like me logo Genes that share expression patterns with MIR627: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR627 Gene

Orthologs for MIR627 Gene

Evolution for MIR627 Gene

ENSEMBL:
Gene Tree for MIR627 (if available)
TreeFam:
Gene Tree for MIR627 (if available)

No data available for Orthologs for MIR627 Gene

Paralogs for MIR627 Gene

No data available for Paralogs for MIR627 Gene

Variants for MIR627 Gene

Sequence variations from dbSNP and Humsavar for MIR627 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs112203612 -- 42,199,180(+) CTCCA(C/T)AAAGA intron-variant, downstream-variant-500B
rs113144057 -- 42,200,262(+) AGAAG(A/G)GCTTT intron-variant, upstream-variant-2KB
rs114386990 -- 42,201,238(+) TGGTG(C/T)GATCA intron-variant, upstream-variant-2KB
rs115909119 -- 42,199,433(+) GCCAG(A/G)GGGAA intron-variant, downstream-variant-500B
rs116541575 -- 42,201,332(+) CACCA(C/T)GTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR627 Gene

Variant ID Type Subtype PubMed ID
nsv1507 CNV insertion 18451855
nsv471683 CNV gain+loss 15918152
nsv832985 CNV loss 17160897

Relevant External Links for MIR627 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR627

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR627 Gene

Disorders for MIR627 Gene

Relevant External Links for MIR627

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR627

No disorders were found for MIR627 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR627 Gene

Publications for MIR627 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer. (PMID: 26607322) Shin V.Y. … Chu K.M. (Mol. Cancer 2015) 3 64
  3. MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. (PMID: 23619147) Padi S.K. … Guo B. (Gastroenterology 2013) 3 64
  4. The repertoire and features of human platelet microRNAs. (PMID: 23226537) PlAc H. … Provost P. (PLoS ONE 2012) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR627 Gene

Sources for MIR627 Gene

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