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Aliases for MIR627 Gene

Subcategory (RNA class) for MIR627 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR627 Gene

  • MicroRNA 627 2 3
  • Hsa-Mir-627 3
  • MIRN627 3

External Ids for MIR627 Gene

Previous HGNC Symbols for MIR627 Gene

  • MIRN627

Previous GeneCards Identifiers for MIR627 Gene

  • GC15M040280
  • GC15M042491

Summaries for MIR627 Gene

Entrez Gene Summary for MIR627 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR627 Gene

MIR627 (MicroRNA 627) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR627 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR627

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR627 Gene

Genomics for MIR627 Gene

Genomic Location for MIR627 Gene

Start:
42,199,570 bp from pter
End:
42,199,666 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR627 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR627 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR627 Gene

ORGUL Member Location for MIR627 Gene

ORGUL Member Location for MIR627 gene

No data available for Regulatory Elements for MIR627 Gene

Proteins for MIR627 Gene

Post-translational modifications for MIR627 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR627 Gene

Domains for MIR627 Gene

Gene Families for MIR627 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR627: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR627 Gene

Function for MIR627 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR627 Gene

Localization for MIR627 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR627 Gene

Pathways for MIR627 Gene

SuperPathways for MIR627 Gene

No Data Available

Interacting Proteins for MIR627 Gene

Gene Ontology (GO) - Biological Process for MIR627 Gene

None

No data available for Pathways by source for MIR627 Gene

Transcripts for MIR627 Gene

fRNAdb Secondary structures for MIR627 Gene

  • hsa-miR-627-5p_MIMAT0003296_Homo_sapiens_miR-627-5p_mature

mRNA/cDNA for MIR627 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR627 Gene

No ASD Table

Relevant External Links for MIR627 Gene

GeneLoc Exon Structure for
MIR627
ECgene alternative splicing isoforms for
MIR627

Expression for MIR627 Gene

mRNA expression in normal human tissues for MIR627 Gene

genes like me logo Genes that share expressions with MIR627: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR627 Gene

Orthologs for MIR627 Gene

Evolution for MIR627 Gene

ENSEMBL:
Gene Tree for MIR627 (if available)
TreeFam:
Gene Tree for MIR627 (if available)

No data available for Orthologs for MIR627 Gene

Paralogs for MIR627 Gene

No data available for Paralogs for MIR627 Gene

Variants for MIR627 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR627 Gene

Variant ID Type Subtype PubMed ID
nsv471683 CNV Gain+Loss 15918152
nsv832985 CNV Loss 17160897
nsv1507 CNV Insertion 18451855

Relevant External Links for MIR627 Gene

HapMap Linkage Disequilibrium report
MIR627

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR627 Gene

Disorders for MIR627 Gene

No disorders were found for MIR627 Gene.

No data available for UniProtKB/Swiss-Prot for MIR627 Gene

Publications for MIR627 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. The repertoire and features of human platelet microRNAs. (PMID: 23226537) PlAc H. … Provost P. (PLoS ONE 2012) 3
  5. MicroRNA-627 mediates the epigenetic mechanisms of vitamin D to suppress proliferation of human colorectal cancer cells and growth of xenograft tumors in mice. (PMID: 23619147) Padi S.K. … Guo B. (Gastroenterology 2013) 3

Products for MIR627 Gene

Sources for MIR627 Gene

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