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Aliases for MIR625 Gene

Subcategory (RNA class) for MIR625 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR625 Gene

  • MicroRNA 625 2 3 5
  • Hsa-Mir-625 3
  • MIRN625 3

External Ids for MIR625 Gene

ORGUL Members for MIR625 Gene

Previous HGNC Symbols for MIR625 Gene

  • MIRN625

Previous GeneCards Identifiers for MIR625 Gene

  • GC14P065008
  • GC14P065937

Summaries for MIR625 Gene

Entrez Gene Summary for MIR625 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR625 Gene

MIR625 (MicroRNA 625) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR625 Gene

Genomics for MIR625 Gene

Regulatory Elements for MIR625 Gene

Enhancers for MIR625 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F065410 1.1 ENCODE 10.2 -58.2 -58172 4.0 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS LOC102723809 YBX1P1 LOC100506321 RPL21P8 MIR625 FUT8 FUT8-AS1 GC14M065468
GH14F065430 1 Ensembl ENCODE 11.2 -38.0 -38035 4.2 HDAC1 ZNF146 PKNOX1 EBF1 GATA3 GATA2 ZSCAN29 ZNF263 SMARCE1 RNF2 FUT8 MIR625 RPL21P8 FUT8-AS1 GC14M065468
GH14F065506 0.7 ENCODE 11.2 +36.0 35956 0.2 SOX13 GATAD2A TFAP4 FOXA3 RARA GATA3 SMARCA4 POLR2A GLIS1 POU5F1 MIR625 RPL21P8 EIF1AXP2 GC14M065471
GH14F065374 0.7 Ensembl ENCODE 10.9 -97.5 -97494 0.8 CTCF GLIS1 RAD21 RPL21P8 MIR625 LOC105370537 GC14M065336
GH14F065469 0.9 Ensembl ENCODE 0.8 +0.0 8 2.3 NR2F1 JUNB USF2 CEBPG RELA RAD51 EED IKZF1 POU5F1 NR2F6 FUT8 GC14M065471 MIR625
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR625 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR625 Gene

Chromosome:
14
Start:
65,471,102 bp from pter
End:
65,471,186 bp from pter
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR625 Gene

Genes around MIR625 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR625 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR625 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR625 Gene

Proteins for MIR625 Gene

Post-translational modifications for MIR625 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR625 Gene

Domains & Families for MIR625 Gene

Gene Families for MIR625 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR625: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR625 Gene

Function for MIR625 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR625 Gene

Localization for MIR625 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR625 Gene

Pathways & Interactions for MIR625 Gene

SuperPathways for MIR625 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR625: view

Pathways by source for MIR625 Gene

1 KEGG pathway for MIR625 Gene

Interacting Proteins for MIR625 Gene

Gene Ontology (GO) - Biological Process for MIR625 Gene

None

No data available for SIGNOR curated interactions for MIR625 Gene

Transcripts for MIR625 Gene

mRNA/cDNA for MIR625 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR625 Gene

No ASD Table

Relevant External Links for MIR625 Gene

GeneLoc Exon Structure for
MIR625
ECgene alternative splicing isoforms for
MIR625

Expression for MIR625 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR625 Gene:

MIR625
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR625 Gene

Orthologs for MIR625 Gene

Evolution for MIR625 Gene

ENSEMBL:
Gene Tree for MIR625 (if available)
TreeFam:
Gene Tree for MIR625 (if available)

No data available for Orthologs for MIR625 Gene

Paralogs for MIR625 Gene

No data available for Paralogs for MIR625 Gene

Variants for MIR625 Gene

Sequence variations from dbSNP and Humsavar for MIR625 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs111912837 -- 65,471,208(+) CTGAG(-/TT)TTGAG intron-variant, downstream-variant-500B
rs112906259 -- 65,470,876(+) GAGGG(A/C/T)GGCGG intron-variant, upstream-variant-2KB
rs113129982 -- 65,471,504(+) AAAGT(A/C)TGGGG intron-variant, downstream-variant-500B
rs114290156 -- 65,471,233(+) TCGGT(C/G)AAAGG intron-variant, downstream-variant-500B
rs115322927 -- 65,469,821(+) GATCT(C/T)GGGGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR625 Gene

Variant ID Type Subtype PubMed ID
nsv976347 CNV duplication 23825009
esv2748779 CNV deletion 23290073

Relevant External Links for MIR625 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR625

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR625 Gene

Disorders for MIR625 Gene

Relevant External Links for MIR625

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR625

No disorders were found for MIR625 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR625 Gene

Publications for MIR625 Gene

  1. miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma. (PMID: 24632613) Zhou X. … Yun J.P. (Oncogene 2015) 3 64
  2. MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells. (PMID: 26314959) Zheng H. … Wang Z. (Oncotarget 2015) 3 64
  3. A three-miRNA signature as promising non-invasive diagnostic marker for gastric cancer. (PMID: 26607322) Shin V.Y. … Chu K.M. (Mol. Cancer 2015) 3 64
  4. miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2. (PMID: 24508466) Wang Z. … Xie Z. (FEBS Lett. 2014) 3 64
  5. High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer. (PMID: 23506979) Rasmussen M.H. … Andersen C.L. (Mol Oncol 2013) 3 64

Products for MIR625 Gene

Sources for MIR625 Gene

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