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Aliases for MIR622 Gene

Subcategory (RNA class) for MIR622 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR622 Gene

  • MicroRNA 622 2 3
  • Hsa-Mir-622 3
  • MIRN622 3

External Ids for MIR622 Gene

ORGUL Members for MIR622 Gene

Previous HGNC Symbols for MIR622 Gene

  • MIRN622

Previous GeneCards Identifiers for MIR622 Gene

  • GC13P089683
  • GC13P090886
  • GC13P090888
  • GC13P090891
  • GC13P090894
  • GC13P090897
  • GC13P090900
  • GC13P090903
  • GC13P090906
  • GC13P090911
  • GC13P090916
  • GC13P090920

Summaries for MIR622 Gene

Entrez Gene Summary for MIR622 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR622 Gene

MIR622 (MicroRNA 622) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR622 Gene

Genomics for MIR622 Gene

Genomic Location for MIR622 Gene

Start:
90,231,182 bp from pter
End:
90,231,277 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR622 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR622 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR622 Gene

No data available for Regulatory Elements for MIR622 Gene

Proteins for MIR622 Gene

Post-translational modifications for MIR622 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR622 Gene

Domains for MIR622 Gene

Gene Families for MIR622 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR622: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR622 Gene

Function for MIR622 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR622 Gene

Localization for MIR622 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR622 Gene

Pathways for MIR622 Gene

SuperPathways for MIR622 Gene

No Data Available

Interacting Proteins for MIR622 Gene

Gene Ontology (GO) - Biological Process for MIR622 Gene

None

No data available for Pathways by source for MIR622 Gene

Transcripts for MIR622 Gene

mRNA/cDNA for MIR622 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR622

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR622 Gene

No ASD Table

Relevant External Links for MIR622 Gene

GeneLoc Exon Structure for
MIR622
ECgene alternative splicing isoforms for
MIR622

Expression for MIR622 Gene

mRNA expression in normal human tissues for MIR622 Gene

genes like me logo Genes that share expressions with MIR622: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR622 Gene

Orthologs for MIR622 Gene

Evolution for MIR622 Gene

ENSEMBL:
Gene Tree for MIR622 (if available)
TreeFam:
Gene Tree for MIR622 (if available)

No data available for Orthologs for MIR622 Gene

Paralogs for MIR622 Gene

No data available for Paralogs for MIR622 Gene

Variants for MIR622 Gene

Sequence variations from dbSNP and Humsavar for MIR622 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs7989199 -- 90,229,508(+) CTGGA(A/G)CTGGA upstream-variant-2KB
rs12857240 -- 90,231,129(+) CTCAC(C/G)AAGAT upstream-variant-2KB
rs66892997 -- 90,231,615(+) GTCCA(A/C)CACCT downstream-variant-500B
rs71111012 -- 90,230,089(-) AGGCC(-/TTTG)TTTGT upstream-variant-2KB
rs73583155 -- 90,230,364(+) CTCGC(C/T)CTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR622 Gene

Variant ID Type Subtype PubMed ID
nsv456064 CNV Loss 19166990
dgv1772n71 CNV Gain 21882294
nsv900877 CNV Gain 21882294

Relevant External Links for MIR622 Gene

HapMap Linkage Disequilibrium report
MIR622

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR622 Gene

Disorders for MIR622 Gene

No disorders were found for MIR622 Gene.

No data available for UniProtKB/Swiss-Prot for MIR622 Gene

Publications for MIR622 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene. (PMID: 21528065) Guo X.B. … Li C.S. (World J. Gastroenterol. 2011) 3
  4. MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol. (PMID: 22016468) Han Z. … Jiang Y. (Carcinogenesis 2012) 3
  5. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S. … Sun J. (Carcinogenesis 2012) 3

Products for MIR622 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR622
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR622
    • Block miRNA regulation of MIR622 using miScript Target Protectors

    Sources for MIR622 Gene

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