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Aliases for MIR621 Gene

Subcategory (RNA class) for MIR621 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR621 Gene

  • MicroRNA 621 2 3 5
  • Hsa-Mir-621 3
  • MIRN621 3

External Ids for MIR621 Gene

ORGUL Members for MIR621 Gene

Previous HGNC Symbols for MIR621 Gene

  • MIRN621

Previous GeneCards Identifiers for MIR621 Gene

  • GC13P040283
  • GC13P041384

Summaries for MIR621 Gene

Entrez Gene Summary for MIR621 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR621 Gene

MIR621 (MicroRNA 621) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR621 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR621 Gene

Genomics for MIR621 Gene

Regulatory Elements for MIR621 Gene

Enhancers for MIR621 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H040813 0.6 ENCODE 0.7 +3.1 3128 1 ELF3 GATAD2A CTCF TEAD1 ARID4B SMC3 RAD21 SLC25A15 WBP4 MIR621 GC13P040827
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR621 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR621 Gene

Chromosome:
13
Start:
40,810,766 bp from pter
End:
40,810,861 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR621 Gene

Genes around MIR621 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR621 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR621 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR621 Gene

Proteins for MIR621 Gene

Post-translational modifications for MIR621 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR621 Gene

Domains & Families for MIR621 Gene

Gene Families for MIR621 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR621: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR621 Gene

Function for MIR621 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR621
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR621 Gene

Localization for MIR621 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR621 Gene

Pathways & Interactions for MIR621 Gene

SuperPathways for MIR621 Gene

No Data Available

Interacting Proteins for MIR621 Gene

Gene Ontology (GO) - Biological Process for MIR621 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR621 Gene

Drugs & Compounds for MIR621 Gene

No Compound Related Data Available

Transcripts for MIR621 Gene

mRNA/cDNA for MIR621 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR621
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR621 Gene

No ASD Table

Relevant External Links for MIR621 Gene

GeneLoc Exon Structure for
MIR621
ECgene alternative splicing isoforms for
MIR621

Expression for MIR621 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR621 Gene

mRNA differential expression in normal tissues according to GTEx for MIR621 Gene

This gene is overexpressed in Liver (x15.3) and Pancreas (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR621 Gene:

MIR621
genes like me logo Genes that share expression patterns with MIR621: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR621 Gene

Orthologs for MIR621 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR621 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-621 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR621 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR621 Gene

ENSEMBL:
Gene Tree for MIR621 (if available)
TreeFam:
Gene Tree for MIR621 (if available)

Paralogs for MIR621 Gene

No data available for Paralogs for MIR621 Gene

Variants for MIR621 Gene

Sequence variations from dbSNP and Humsavar for MIR621 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs104894431 Pathogenic 40,809,585(+) GATTC(A/G)AGCAT intron-variant, upstream-variant-2KB, reference, missense
rs121908535 Pathogenic 40,809,576(+) ACCTA(C/T)TATGA intron-variant, upstream-variant-2KB, reference, missense
rs202247807 Pathogenic 40,809,584(+) TGATT(C/T)GAGCA intron-variant, upstream-variant-2KB, reference, stop-gained
rs202247808 Pathogenic 40,809,579(+) TACTA(A/T)GATTC intron-variant, upstream-variant-2KB, reference, missense
rs202247809 Pathogenic 40,809,608(+) GAGCA(C/T)TCTTT intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR621 Gene

Variant ID Type Subtype PubMed ID
esv3892332 CNV gain 25118596

Relevant External Links for MIR621 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR621

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR621 Gene

Disorders for MIR621 Gene

Relevant External Links for MIR621

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR621

No disorders were found for MIR621 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR621 Gene

Publications for MIR621 Gene

  1. MiRNA-621 sensitizes breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. (PMID: 25867061) Xue J … Wu J (Oncogene 2016) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 60

Products for MIR621 Gene

Sources for MIR621 Gene

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