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Aliases for MIR619 Gene

Subcategory (RNA class) for MIR619 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR619 Gene

  • MicroRNA 619 2 3 5
  • Hsa-Mir-619 3
  • MiR-619-5p 3
  • MIRN619 3

External Ids for MIR619 Gene

Previous HGNC Symbols for MIR619 Gene

  • MIRN619

Previous GeneCards Identifiers for MIR619 Gene

  • GC12M107755
  • GC12M109230

Summaries for MIR619 Gene

Entrez Gene Summary for MIR619 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR619 Gene

MIR619 (MicroRNA 619) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR619 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR619

Additional gene information for MIR619 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR619 Gene

Genomics for MIR619 Gene

Regulatory Elements for MIR619 Gene

Enhancers for MIR619 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H108797 1.4 Ensembl ENCODE dbSUPER 11.5 +34.1 34079 9 HDGF ARNT ARID4B BATF DNMT3B ZNF2 RAD21 ZNF143 RCOR1 FOS CORO1C SSH1 MIR619 SELPLG RNU7-169P TMEM119 ACACB ENSG00000257221 LOC101929204 ENSG00000274598
GH12H108808 0.4 dbSUPER 11.6 +28.5 28457 0 ZNF121 SP7 SSH1 MIR619 CORO1C SELPLG RNU7-169P TMEM119 LOC101929204 ENSG00000274598
GH12H108849 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -17.4 -17374 9 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B ZNF766 ZNF143 ZNF207 FOS SART3 ALKBH2 UBE3B CORO1C SSH1 ENSG00000257221 SELPLG MIR619
GH12H108845 1 Ensembl ENCODE dbSUPER 0.4 -9.4 -9366 2 POLR2A IKZF1 RCOR1 EBF1 MIR619 SSH1
GH12H108848 0.4 dbSUPER 0.4 -12.0 -11994 1 BCOR CTCF SSH1 MIR619
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR619 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR619 Gene

Chromosome:
12
Start:
108,836,908 bp from pter
End:
108,837,006 bp from pter
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR619 Gene

Genes around MIR619 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR619 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR619 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR619 Gene

ORGUL Member Location for MIR619 Gene

ORGUL Member Location for MIR619 gene

Proteins for MIR619 Gene

Post-translational modifications for MIR619 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR619 Gene

Domains & Families for MIR619 Gene

Gene Families for MIR619 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR619: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR619 Gene

Function for MIR619 Gene

Phenotypes From GWAS Catalog for MIR619 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR619
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR619 Gene

Localization for MIR619 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR619 Gene

Pathways & Interactions for MIR619 Gene

SuperPathways for MIR619 Gene

No Data Available

Interacting Proteins for MIR619 Gene

Gene Ontology (GO) - Biological Process for MIR619 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR619 Gene

Drugs & Compounds for MIR619 Gene

No Compound Related Data Available

Transcripts for MIR619 Gene

fRNAdb Secondary structures for MIR619 Gene

  • FR261059
  • hsa-miR-619-3p_MIMAT0003288_Homo_sapiens_miR-619-3p_mature

mRNA/cDNA for MIR619 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR619
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR619 Gene

No ASD Table

Relevant External Links for MIR619 Gene

GeneLoc Exon Structure for
MIR619
ECgene alternative splicing isoforms for
MIR619

Expression for MIR619 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR619 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR619 Gene:

MIR619
genes like me logo Genes that share expression patterns with MIR619: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR619 Gene

Orthologs for MIR619 Gene

Evolution for MIR619 Gene

ENSEMBL:
Gene Tree for MIR619 (if available)
TreeFam:
Gene Tree for MIR619 (if available)

No data available for Orthologs for MIR619 Gene

Paralogs for MIR619 Gene

No data available for Paralogs for MIR619 Gene

Variants for MIR619 Gene

Sequence variations from dbSNP and Humsavar for MIR619 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000674328 -- 108,836,886(+) TCAGA(C/T)ACACT intron-variant, downstream-variant-500B
rs1001110968 -- 108,836,598(+) TGAAT(A/G)AAACA intron-variant, downstream-variant-500B
rs1002361171 -- 108,837,503(+) CCAAG(A/G)GTAAT intron-variant, upstream-variant-2KB
rs1003659971 -- 108,838,349(+) AGAAC(A/G)ATGAA intron-variant, upstream-variant-2KB
rs1005138970 -- 108,837,432(+) ATGCA(C/T)CAGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR619 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV duplication 17116639

Relevant External Links for MIR619 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR619

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR619 Gene

Disorders for MIR619 Gene

Relevant External Links for MIR619

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR619

No disorders were found for MIR619 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR619 Gene

Publications for MIR619 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 60
  2. Plasma Levels of hsa-miR-619-5p and hsa-miR-1184 Differ in Prostatic Benign Hyperplasia and Cancer. (PMID: 27265125) Knyazev EN … Shkurnikov MY (Bulletin of experimental biology and medicine 2016) 3 60
  3. The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes. (PMID: 25162022) Ivashchenko A … Atambayeva S (BioMed research international 2014) 3 60
  4. The repertoire and features of human platelet microRNAs. (PMID: 23226537) Plé H … Provost P (PloS one 2012) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR619 Gene

Sources for MIR619 Gene

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