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Aliases for MIR619 Gene

Subcategory (RNA class) for MIR619 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR619 Gene

  • MicroRNA 619 2 3 5
  • Hsa-Mir-619 3
  • MiR-619-5p 3
  • MIRN619 3

External Ids for MIR619 Gene

Previous HGNC Symbols for MIR619 Gene

  • MIRN619

Previous GeneCards Identifiers for MIR619 Gene

  • GC12M107755
  • GC12M109230

Summaries for MIR619 Gene

Entrez Gene Summary for MIR619 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR619 Gene

MIR619 (MicroRNA 619) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR619 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR619

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR619 Gene

Genomics for MIR619 Gene

Regulatory Elements for MIR619 Gene

Enhancers for MIR619 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F108797 1.3 Ensembl ENCODE 11.5 +34.1 34079 10.0 HDGF PKNOX1 ATF1 MLX ARID4B ZNF2 YY1 ZNF143 FOS REST CORO1C SSH1 MIR619 SELPLG RNU7-169P TMEM119 ACACB MIR4496 LOC101929204 ENSG00000274598
GH12F108849 1.8 FANTOM5 Ensembl ENCODE 0.3 -17.4 -17374 9.6 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF207 SART3 ALKBH2 UBE3B CORO1C SSH1 MIR4496 SELPLG MIR619
GH12F108845 0.8 Ensembl ENCODE 0.4 -9.4 -9366 2.3 SMARCA4 POLR2A IKZF1 REST EBF1 MIR619 SSH1
GH12F108842 0.5 ENCODE 0.4 -5.6 -5644 0.6 ZNF121 POLR2A ZBTB40 MIR619 SSH1
GH12F108843 0.4 Ensembl 0.4 -6.3 -6295 0.2 POLR2A MIR619 SSH1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR619 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR619 Gene

Chromosome:
12
Start:
108,836,908 bp from pter
End:
108,837,006 bp from pter
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR619 Gene

Genes around MIR619 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR619 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR619 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR619 Gene

ORGUL Member Location for MIR619 Gene

ORGUL Member Location for MIR619 gene

Proteins for MIR619 Gene

Post-translational modifications for MIR619 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR619 Gene

Domains & Families for MIR619 Gene

Gene Families for MIR619 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR619: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR619 Gene

Function for MIR619 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR619 Gene

Localization for MIR619 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR619 Gene

Pathways & Interactions for MIR619 Gene

SuperPathways for MIR619 Gene

No Data Available

Interacting Proteins for MIR619 Gene

Gene Ontology (GO) - Biological Process for MIR619 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR619 Gene

Transcripts for MIR619 Gene

fRNAdb Secondary structures for MIR619 Gene

  • FR261059
  • hsa-miR-619-3p_MIMAT0003288_Homo_sapiens_miR-619-3p_mature

mRNA/cDNA for MIR619 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR619 Gene

No ASD Table

Relevant External Links for MIR619 Gene

GeneLoc Exon Structure for
MIR619
ECgene alternative splicing isoforms for
MIR619

Expression for MIR619 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR619 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR619 Gene:

MIR619
genes like me logo Genes that share expression patterns with MIR619: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR619 Gene

Orthologs for MIR619 Gene

Evolution for MIR619 Gene

ENSEMBL:
Gene Tree for MIR619 (if available)
TreeFam:
Gene Tree for MIR619 (if available)

No data available for Orthologs for MIR619 Gene

Paralogs for MIR619 Gene

No data available for Paralogs for MIR619 Gene

Variants for MIR619 Gene

Sequence variations from dbSNP and Humsavar for MIR619 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs113592997 -- 108,836,660(+) TAATT(C/T)TAAAG intron-variant, downstream-variant-500B
rs113648355 -- 108,837,462(+) GCTGT(G/T)TTGCG intron-variant, upstream-variant-2KB
rs115029237 -- 108,838,139(+) AACAC(A/G)ACCTG intron-variant, upstream-variant-2KB
rs116433281 -- 108,838,906(+) GCTAT(A/G)TCATG intron-variant, upstream-variant-2KB
rs116953653 -- 108,837,854(+) GCTCA(C/T)GCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR619 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV duplication 17116639

Relevant External Links for MIR619 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR619

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR619 Gene

Disorders for MIR619 Gene

Relevant External Links for MIR619

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR619

No disorders were found for MIR619 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR619 Gene

Publications for MIR619 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. The properties of binding sites of miR-619-5p, miR-5095, miR-5096, and miR-5585-3p in the mRNAs of human genes. (PMID: 25162022) Ivashchenko A. … Atambayeva S. (Biomed Res Int 2014) 3 64
  3. The repertoire and features of human platelet microRNAs. (PMID: 23226537) PlAc H. … Provost P. (PLoS ONE 2012) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR619 Gene

Sources for MIR619 Gene

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