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Aliases for MIR618 Gene

Subcategory (RNA class) for MIR618 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR618 Gene

  • MicroRNA 618 2 3 5
  • Hsa-Mir-618 3
  • Mir-618 3
  • MIRN618 3

External Ids for MIR618 Gene

Previous HGNC Symbols for MIR618 Gene

  • MIRN618

Previous GeneCards Identifiers for MIR618 Gene

  • GC12M079854
  • GC12M081329

Summaries for MIR618 Gene

Entrez Gene Summary for MIR618 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR618 Gene

MIR618 (MicroRNA 618) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR618 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR618 Gene

Genomics for MIR618 Gene

Regulatory Elements for MIR618 Gene

Enhancers for MIR618 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F080925 0.5 ENCODE 0.4 +10.4 10417 0.2 MIR618 GC12M080862 LOC100420442
GH12F080893 0.2 ENCODE 0.2 +42.1 42137 0.2 LIN7A LOC100420442 GC12M080862 MIR618
GH12F080862 0.2 Ensembl 0.2 +73.1 73133 0.2 LIN7A GC12M080862 LOC100420442 MIR618
GH12F080863 0.4 Ensembl 0.2 +73.5 73533 0.2 CTCF CEBPB FOS GC12M080862 LOC100420442 MIR618
GH12F080877 0.6 FANTOM5 0.2 +57.9 57942 0.1 NR2F2 LIN7A LOC100420442 GC12M080862 MIR618
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR618 on UCSC Golden Path with GeneCards custom track

Promoters for MIR618 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000653972 -1367 2801 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 GLIS2 FOS ZNF263 SP3

Genomic Location for MIR618 Gene

Chromosome:
12
Start:
80,935,736 bp from pter
End:
80,935,833 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR618 Gene

Genes around MIR618 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR618 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR618 Gene

ORGUL Member Location for MIR618 Gene

ORGUL Member Location for MIR618 gene

Proteins for MIR618 Gene

Post-translational modifications for MIR618 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR618 Gene

Domains & Families for MIR618 Gene

Gene Families for MIR618 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR618: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR618 Gene

Function for MIR618 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR618 Gene

Localization for MIR618 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR618 Gene

Pathways & Interactions for MIR618 Gene

SuperPathways for MIR618 Gene

No Data Available

Interacting Proteins for MIR618 Gene

Gene Ontology (GO) - Biological Process for MIR618 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR618 Gene

Transcripts for MIR618 Gene

mRNA/cDNA for MIR618 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR618 Gene

No ASD Table

Relevant External Links for MIR618 Gene

GeneLoc Exon Structure for
MIR618
ECgene alternative splicing isoforms for
MIR618

Expression for MIR618 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR618 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR618 Gene:

MIR618
genes like me logo Genes that share expression patterns with MIR618: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR618 Gene

Orthologs for MIR618 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR618 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-618 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR618 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR618 Gene

ENSEMBL:
Gene Tree for MIR618 (if available)
TreeFam:
Gene Tree for MIR618 (if available)

Paralogs for MIR618 Gene

No data available for Paralogs for MIR618 Gene

Variants for MIR618 Gene

Sequence variations from dbSNP and Humsavar for MIR618 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111921327 -- 80,935,946(+) TAGTA(A/G)TGGTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112896026 -- 80,936,195(+) ATTAT(A/G)CAATG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs11387348 -- 80,936,736(+) AGCTT(-/G)GTGAG intron-variant, upstream-variant-2KB
rs114099308 -- 80,936,920(+) GAGAA(A/G)CCGAG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs114953945 -- 80,937,173(+) CTCGC(C/T)CTCCG intron-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR618 Gene

Variant ID Type Subtype PubMed ID
esv3580346 CNV loss 25503493
nsv789 CNV deletion 18451855

Relevant External Links for MIR618 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR618

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR618 Gene

Disorders for MIR618 Gene

Relevant External Links for MIR618

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR618

No disorders were found for MIR618 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR618 Gene

Publications for MIR618 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis. (PMID: 24503492) Fu A. … Zhu Y. (Epigenetics 2014) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR618 Gene

Sources for MIR618 Gene

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