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Aliases for MIR618 Gene

Subcategory (RNA class) for MIR618 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR618 Gene

  • MicroRNA 618 2 3
  • Hsa-Mir-618 3
  • MIRN618 3

External Ids for MIR618 Gene

Previous Symbols for MIR618 Gene

  • MIRN618

Summaries for MIR618 Gene

Entrez Gene Summary for MIR618 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR618 Gene

MIR618 (MicroRNA 618) is a RNA Gene, and belongs to miRNA RNA class.

fRNAdb sequence ontologies for MIR618 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR618 Gene

Genomics for MIR618 Gene

Genomic Location for MIR618 Gene

Start:
80,935,736 bp from pter
End:
80,935,833 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR618 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR618 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR618 Gene

ORGUL Member Location for MIR618 Gene

ORGUL Member Location for MIR618 gene

No data available for Regulatory Elements for MIR618 Gene

Proteins for MIR618 Gene

Post-translational modifications for MIR618 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR618 Gene

Domains for MIR618 Gene

Gene Families for MIR618 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR618: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR618 Gene

Function for MIR618 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR618 Gene

Localization for MIR618 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR618 Gene

Pathways for MIR618 Gene

SuperPathways for MIR618 Gene

No Data Available

Interacting Proteins for MIR618 Gene

Gene Ontology (GO) - Biological Process for MIR618 Gene

None

No data available for Pathways by source for MIR618 Gene

Transcripts for MIR618 Gene

mRNA/cDNA for MIR618 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR618 Gene

No ASD Table

Relevant External Links for MIR618 Gene

GeneLoc Exon Structure for
MIR618
ECgene alternative splicing isoforms for
MIR618

Expression for MIR618 Gene

mRNA expression in normal human tissues for MIR618 Gene

genes like me logo Genes that share expressions with MIR618: view

Orthologs for MIR618 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR618 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-618 37
  • 99 (a)
OneToOne
Species with no ortholog for MIR618:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR618 Gene

ENSEMBL:
Gene Tree for MIR618 (if available)
TreeFam:
Gene Tree for MIR618 (if available)

Paralogs for MIR618 Gene

No data available for Paralogs for MIR618 Gene

Variants for MIR618 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR618 Gene

Variant ID Type Subtype PubMed ID
nsv789 CNV Loss 18451855

Relevant External Links for MIR618 Gene

HapMap Linkage Disequilibrium report
MIR618

No data available for Sequence variations from dbSNP and Humsavar for MIR618 Gene

Disorders for MIR618 Gene

No disorders were found for MIR618 Gene.

No data available for UniProtKB/Swiss-Prot for MIR618 Gene

Publications for MIR618 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Targetome profiling and functional genetics implicate miR-618 in lymphomagenesis. (PMID: 24503492) Fu A. … Zhu Y. (Epigenetics 2014) 3

Products for MIR618 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR618
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR618
    • Block miRNA regulation of MIR618 using miScript Target Protectors

    Sources for MIR618 Gene

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