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Aliases for MIR616 Gene

Subcategory (RNA class) for MIR616 Gene


Quality Score for this RNA gene is


Aliases for MIR616 Gene

  • MicroRNA 616 2 3 5
  • Hsa-Mir-616 3
  • MIRN616 3

External Ids for MIR616 Gene

Previous HGNC Symbols for MIR616 Gene

  • MIRN616

Previous GeneCards Identifiers for MIR616 Gene

  • GC12M056200
  • GC12M057912

Summaries for MIR616 Gene

Entrez Gene Summary for MIR616 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR616 Gene

MIR616 (MicroRNA 616) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR616 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR616 Gene

Genomics for MIR616 Gene

Regulatory Elements for MIR616 Gene

Enhancers for MIR616 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057743 1.1 ENCODE 9.7 -225.9 -225863 2.7 HDGF PKNOX1 CREB3L1 SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS KLF13 TSFM CYP27B1 METTL1 METTL21B NEMP1 DDIT3 MBD6 MIR616 ATP23 TSPAN31
GH12F057376 1 ENCODE 10.2 +142.1 142054 1.5 HDGF ATF1 ARNT SIN3A GATA2 KLF13 ZNF263 SP3 NCOA1 REST RNU6-879P INHBE GLI1 ARHGEF25 DDIT3 MBD6 MIR616 ARHGAP9 ENSG00000224713 GC12P057416
GH12F057319 0.9 Ensembl ENCODE 10.8 +199.5 199475 1.6 PKNOX1 RNF2 MIER1 ZMYM3 GATA2 ADNP HMBOX1 MLLT1 PRDM1 SP7 ARHGAP9 RNU6-879P INHBE GLI1 MIR616 DDIT3 MBD6 MARS TSFM ENSG00000224713
GH12F057575 0.9 ENCODE 10.4 -57.4 -57402 1.4 TBP ARID4B ZNF48 RARA SLC30A9 GATA4 CREM THAP11 SP5 MXD4 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 KIF5A DCTN2 B4GALNT1 DDIT3 MBD6 MIR616
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR616 on UCSC Golden Path with GeneCards custom track

Promoters for MIR616 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR616 Gene

57,519,163 bp from pter
57,519,259 bp from pter
97 bases
Minus strand

Genomic View for MIR616 Gene

Genes around MIR616 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR616 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR616 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR616 Gene

ORGUL Member Location for MIR616 Gene

ORGUL Member Location for MIR616 gene

Proteins for MIR616 Gene

Post-translational modifications for MIR616 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR616 Gene

Domains & Families for MIR616 Gene

Gene Families for MIR616 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR616: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR616 Gene

Function for MIR616 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR616 Gene

Localization for MIR616 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR616 Gene

Pathways & Interactions for MIR616 Gene

SuperPathways for MIR616 Gene

No Data Available

Interacting Proteins for MIR616 Gene

Gene Ontology (GO) - Biological Process for MIR616 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR616 Gene

Transcripts for MIR616 Gene

mRNA/cDNA for MIR616 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR616 Gene

No ASD Table

Relevant External Links for MIR616 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR616 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR616 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR616 Gene:

genes like me logo Genes that share expression patterns with MIR616: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR616 Gene

Orthologs for MIR616 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR616 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-616 35
  • 98 (a)
-- 35
  • 52 (a)
-- 35
  • 36 (a)
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
Species where no ortholog for MIR616 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR616 Gene

Gene Tree for MIR616 (if available)
Gene Tree for MIR616 (if available)

Paralogs for MIR616 Gene

No data available for Paralogs for MIR616 Gene

Variants for MIR616 Gene

Sequence variations from dbSNP and Humsavar for MIR616 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10717326 -- 57,520,782(+) GTAGC(-/G)GGGGG intron-variant, upstream-variant-2KB
rs112131788 -- 57,520,766(+) GCGCG(C/G)GGAGG intron-variant, upstream-variant-2KB
rs117126958 -- 57,520,664(+) CCGCC(C/G)CCGTC upstream-variant-2KB
rs139060643 -- 57,520,334(+) CTGTG(C/G)AGGAG intron-variant, upstream-variant-2KB
rs141463529 -- 57,520,755(+) GAGTC(A/T)TGCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR616 Gene

Variant ID Type Subtype PubMed ID
nsv559036 CNV loss 21841781
nsv559034 CNV loss 21841781
nsv482992 CNV gain+loss 15286789
nsv469411 CNV loss 19166990
nsv428283 CNV gain 18775914
esv2759901 CNV gain 17122850
dgv2651n54 CNV loss 21841781

Relevant External Links for MIR616 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR616 Gene

Disorders for MIR616 Gene

Relevant External Links for MIR616

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR616 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR616 Gene

Publications for MIR616 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN. (PMID: 26499912) Zhang D. … Zhang L. (Oncol. Rep. 2016) 3 64
  3. A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis. (PMID: 23497787) Liu M.E. … Juo S.H. (Atherosclerosis 2013) 3 64
  4. MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2. (PMID: 21224345) Ma S. … Chan K.W. (Cancer Res. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR616 Gene

Sources for MIR616 Gene

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