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Aliases for MIR616 Gene

Subcategory (RNA class) for MIR616 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR616 Gene

  • MicroRNA 616 2 3 5
  • Hsa-Mir-616 3
  • MIRN616 3

External Ids for MIR616 Gene

Previous HGNC Symbols for MIR616 Gene

  • MIRN616

Previous GeneCards Identifiers for MIR616 Gene

  • GC12M056200
  • GC12M057912

Summaries for MIR616 Gene

Entrez Gene Summary for MIR616 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR616 Gene

MIR616 (MicroRNA 616) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR616 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR616 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR616 Gene

Genomics for MIR616 Gene

GeneHancer (GH) Regulatory Elements for MIR616 Gene

Promoters and enhancers for MIR616 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I057516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.8 -1830 8.8 CLOCK FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MBD6 DDIT3 MIR616 NEMP1 BAZ2A RN7SL809P EEF1AKMT3 DTX3 CDK4 CTDSP2
GH12I057743 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 -225.9 -225862 2.7 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 PIR55823 TSFM ATP23 ZBTB39 PRIM1 CYP27B1 EEF1AKMT3 METTL1 CDK4 NEMP1
GH12I057575 Enhancer 0.8 ENCODE 10.4 -57.4 -57401 1.4 FOXA2 ARID4B ZNF48 RARA SLC30A9 ATF7 CREM THAP11 SP5 MXD4 DTX3 ARHGEF25 SLC26A10 ENSG00000224713 DCTN2 KIF5A B4GALNT1 DDIT3 MIR616 MBD6
GH12I057579 Enhancer 0.8 ENCODE 10.2 -60.6 -60621 0.8 DRAP1 ELF3 SOX13 MXI1 FOXA2 SAP130 ARID4B ZNF384 CEBPG DMAP1 DCTN2 DTX3 ARHGEF25 SLC26A10 ENSG00000224713 KIF5A B4GALNT1 TSPAN31 AGAP2 MBD6
GH12I057376 Enhancer 0.8 ENCODE 10.2 +142.1 142053 1.5 HDAC1 ATF1 ZBTB40 CHAMP1 TCF12 ZNF766 GATA2 ATF7 CREM NCOA1 DTX3 RNU6-879P INHBE GLI1 ARHGEF25 SLC26A10 DDIT3 MBD6 MIR616 ARHGAP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR616 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR616 Gene

Genomic Locations for MIR616 Gene
chr12:57,519,163-57,519,259
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr12:57,912,946-57,913,042
(GRCh37/hg19)

Genomic View for MIR616 Gene

Genes around MIR616 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR616 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR616 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR616 Gene

ORGUL Member Location for MIR616 Gene

ORGUL Member Location for MIR616 gene

Proteins for MIR616 Gene

Post-translational modifications for MIR616 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR616 Gene

Domains & Families for MIR616 Gene

Gene Families for MIR616 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR616: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR616 Gene

Function for MIR616 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR616 Gene

Localization for MIR616 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR616 Gene

Pathways & Interactions for MIR616 Gene

SuperPathways for MIR616 Gene

No Data Available

Interacting Proteins for MIR616 Gene

Gene Ontology (GO) - Biological Process for MIR616 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR616 Gene

Drugs & Compounds for MIR616 Gene

No Compound Related Data Available

Transcripts for MIR616 Gene

mRNA/cDNA for MIR616 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR616 Gene

No ASD Table

Relevant External Links for MIR616 Gene

GeneLoc Exon Structure for
MIR616
ECgene alternative splicing isoforms for
MIR616

Expression for MIR616 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR616 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR616 Gene:

MIR616
genes like me logo Genes that share expression patterns with MIR616: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR616 Gene

Orthologs for MIR616 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR616 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-616 34
  • 98 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 36 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
OneToOne
Species where no ortholog for MIR616 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR616 Gene

ENSEMBL:
Gene Tree for MIR616 (if available)
TreeFam:
Gene Tree for MIR616 (if available)

Paralogs for MIR616 Gene

No data available for Paralogs for MIR616 Gene

Variants for MIR616 Gene

Sequence variations from dbSNP and Humsavar for MIR616 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000179989 -- 57,519,646(-) G/C upstream_transcript_variant
rs1000204759 -- 57,519,297(-) C/T upstream_transcript_variant
rs1000321044 -- 57,518,956(-) G/A/C downstream_transcript_variant
rs1000576589 -- 57,520,323(-) A/G upstream_transcript_variant
rs1000632053 -- 57,519,244(-) T/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR616 Gene

Variant ID Type Subtype PubMed ID
dgv2651n54 CNV loss 21841781
esv2759901 CNV gain 17122850
nsv428283 CNV gain 18775914
nsv469411 CNV loss 19166990
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781
nsv559036 CNV loss 21841781

Additional Variant Information for MIR616 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR616

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR616 Gene

Disorders for MIR616 Gene

Additional Disease Information for MIR616

No disorders were found for MIR616 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR616 Gene

Publications for MIR616 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN. (PMID: 26499912) Zhang D … Zhang L (Oncology reports 2016) 3 58
  3. Relationship of microRNA 616 gene polymorphism with prognosis of patients with premature coronary artery disease. (PMID: 27615006) Zhang Y … Wang C (International journal of clinical pharmacology and therapeutics 2016) 3 58
  4. A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis. (PMID: 23497787) Liu ME … Juo SH (Atherosclerosis 2013) 3 58
  5. MicroRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2. (PMID: 21224345) Ma S … Chan KW (Cancer research 2011) 3 58

Products for MIR616 Gene

Sources for MIR616 Gene

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