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Aliases for MIR615 Gene

Subcategory (RNA class) for MIR615 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR615 Gene

  • MicroRNA 615 2 3 5
  • Hsa-Mir-615 3
  • Mir-615 3
  • MIRN615 3

External Ids for MIR615 Gene

ORGUL Members for MIR615 Gene

Previous HGNC Symbols for MIR615 Gene

  • MIRN615

Previous GeneCards Identifiers for MIR615 Gene

  • GC12U901015
  • GC12P052716
  • GC12P054427

Summaries for MIR615 Gene

Entrez Gene Summary for MIR615 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR615 Gene

MIR615 (MicroRNA 615) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR615 Gene

Genomics for MIR615 Gene

Regulatory Elements for MIR615 Gene

Enhancers for MIR615 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G053971 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -43.7 -43708 36.8 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZNF740 MAP3K12 ENSG00000258344 LOC100652999 HOXC8 HOXC5 SP1 HOTAIR CBX5 HOXC4
GH12G054195 1.5 FANTOM5 Ensembl ENCODE 11.8 +162.7 162726 3.1 HDGF PKNOX1 KLF17 ZNF121 GLIS2 ZNF366 SMARCC2 FOS KLF7 KDM4B MAP3K12 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR196A2 MIR615 HOXC4 HOXC5
GH12G054191 1.2 Ensembl ENCODE 11.6 +157.8 157788 0.9 ATF1 WRNIP1 ARID4B SIN3A ZNF2 ZNF143 KLF7 DEK SP3 YY2 HOXC8 HOXC-AS1 HOXC-AS2 HOXC9 HOXC6 MIR615 HOXC4 HOXC5 MAP3K12 LOC102724030
GH12G054130 1.2 ENCODE dbSUPER 11.5 +100.8 100814 8.3 FOXA2 ZSCAN4 KLF17 FEZF1 RAD21 RARA ZNF121 MIXL1 DEK EGR2 FLJ12825 TARBP2 SMUG1 MIR615 HOXC5 HOXC4 HOXC6 ENSG00000260470 HOXC8 HOXC-AS1
GH12G054079 1.1 ENCODE 10.7 +47.3 47339 4.6 HDGF PKNOX1 CREB3L1 ARNT FEZF1 ZNF2 YY1 CBX5 REST KAT8 FLJ12825 CBX5 MIR615 HOXC4 HOXC5 HOXC6 MAP3K12 HOXC8 HOXC-AS1 HOXC-AS2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR615 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR615 Gene

Chromosome:
12
Start:
54,033,950 bp from pter
End:
54,034,045 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR615 Gene

Genes around MIR615 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR615 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR615 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR615 Gene

Proteins for MIR615 Gene

Post-translational modifications for MIR615 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR615 Gene

Domains & Families for MIR615 Gene

Gene Families for MIR615 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR615: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR615 Gene

Function for MIR615 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR615 Gene

Localization for MIR615 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR615 Gene

Pathways & Interactions for MIR615 Gene

SuperPathways for MIR615 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR615: view

Pathways by source for MIR615 Gene

1 KEGG pathway for MIR615 Gene

Interacting Proteins for MIR615 Gene

Gene Ontology (GO) - Biological Process for MIR615 Gene

None

No data available for SIGNOR curated interactions for MIR615 Gene

Transcripts for MIR615 Gene

mRNA/cDNA for MIR615 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR615 Gene

No ASD Table

Relevant External Links for MIR615 Gene

GeneLoc Exon Structure for
MIR615
ECgene alternative splicing isoforms for
MIR615

Expression for MIR615 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR615 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR615 Gene:

MIR615
genes like me logo Genes that share expression patterns with MIR615: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR615 Gene

Orthologs for MIR615 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR615 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-615 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-615 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir615 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-615 35
  • 96 (a)
OneToOne
Species where no ortholog for MIR615 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR615 Gene

ENSEMBL:
Gene Tree for MIR615 (if available)
TreeFam:
Gene Tree for MIR615 (if available)

Paralogs for MIR615 Gene

No data available for Paralogs for MIR615 Gene

Variants for MIR615 Gene

Sequence variations from dbSNP and Humsavar for MIR615 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000396997 -- 54,033,853(+) GGAGC(C/G)CGGGG intron-variant, upstream-variant-2KB
rs1000873736 -- 54,034,219(+) GGGGA(C/T)GGGGG intron-variant, downstream-variant-500B
rs1001439680 -- 54,034,180(+) CCTCT(C/T)CCTCC intron-variant, downstream-variant-500B
rs1001521503 -- 54,033,461(+) GCTAA(A/G)AGCAG intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1002445805 -- 54,032,701(+) CACCG(A/G)AAAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR615 Gene

Variant ID Type Subtype PubMed ID
esv2759900 CNV gain+loss 17122850
nsv428282 CNV gain 18775914
nsv558998 CNV loss 21841781
nsv826379 CNV gain 20364138
nsv832418 CNV loss 17160897

Relevant External Links for MIR615 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR615

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR615 Gene

Disorders for MIR615 Gene

Relevant External Links for MIR615

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR615

No disorders were found for MIR615 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR615 Gene

Publications for MIR615 Gene

  1. miR-615-5p prevents proliferation and migration through negatively regulating serine hydromethyltransferase 2 (SHMT2) in hepatocellular carcinoma. (PMID: 26662310) Wu X. … Liang G. (Tumour Biol. 2016) 3 64
  2. CDX2 inhibits pancreatic adenocarcinoma cell proliferation via promoting tumor suppressor miR-615-5p. (PMID: 26269116) Jiang Y. … Zhang J. (Tumour Biol. 2016) 3 64
  3. miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. (PMID: 24769899) Gao W. … Miao Y. (Oncogene 2015) 3 64
  4. PU.1 Is Identified as a Novel Metastasis Suppressor in Hepatocellular Carcinoma Regulating the miR-615-5p/IGF2 Axis. (PMID: 25987019) Song L.J. … Wang L.X. (Asian Pac. J. Cancer Prev. 2015) 3 64
  5. MiRNA-615-5p Functions as a Tumor Suppressor in Pancreatic Ductal Adenocarcinoma by Targeting AKT2. (PMID: 25856297) Sun Y. … Chen J. (PLoS ONE 2015) 3 64

Products for MIR615 Gene

Sources for MIR615 Gene

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