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Aliases for MIR614 Gene

Subcategory (RNA class) for MIR614 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR614 Gene

  • MicroRNA 614 2 3
  • GPRC5A 4 5
  • G-Protein Coupled Receptor Family C Group 5 Member A 4
  • G Protein-Coupled Receptor Class C Group 5 Member A 5
  • Retinoic Acid-Induced Gene 1 Protein 4
  • Phorbol Ester Induced Gene 1 4
  • Hsa-Mir-614 3
  • MIRN614 3
  • GPCR5A 4
  • PEIG-1 4
  • RAIG-1 4
  • RAIG1 4
  • RAI3 4

External Ids for MIR614 Gene

Previous HGNC Symbols for MIR614 Gene

  • MIRN614

Previous GeneCards Identifiers for MIR614 Gene

  • GC12P012961
  • GC12P013068
  • GC12P012918

Summaries for MIR614 Gene

Entrez Gene Summary for MIR614 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR614 Gene

MIR614 (MicroRNA 614) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Integrated Pancreatic Cancer Pathway and GPCRs, Class C Metabotropic glutamate, pheromone. An important paralog of this gene is GPRC5D.

UniProtKB/Swiss-Prot for MIR614 Gene

  • Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR614 Gene

Genomics for MIR614 Gene

Regulatory Elements for MIR614 Gene

Enhancers for MIR614 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F013043 0.8 ENCODE 20.8 +153.7 153700 1.3 PKNOX1 CREB3L1 ZNF133 ARID4B SIN3A GLI4 DMAP1 ZNF48 ZNF2 YY1 FAM234B MIR614 HEBP1 ENSG00000255621 HTR7P1 DDX47 EMP1 GC12P013050
GH12F013193 1 FANTOM5 Ensembl ENCODE 11.9 +312.3 312311 19.5 PKNOX1 ZNF133 SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS YY2 REST HTR7P1 MIR614 GSG1 LOC100506314 ENSG00000255621 HEBP1 ENSG00000221611 ENSG00000256011 GPRC5D FAM234B
GH12F012834 0.9 Ensembl ENCODE 11.8 -52.2 -52199 8.9 PKNOX1 SIN3A FEZF1 BRCA1 ZNF2 GTF3C2 ZNF121 GLIS2 KLF7 FOS DDX47 RPL13AP20 GPRC5A MIR614 ENSG00000256011 LOC100506314 GPRC5D GC12P012833 RPL37AP9
GH12F012845 1 Ensembl ENCODE 11.7 -44.9 -44902 0.6 OSR2 SCRT1 ZSCAN23 ZBTB49 ZFP3 SCRT2 PRDM10 PRDM1 MIR614 GPRC5A GPRC5D ENSG00000256011 GC12P012841 RPS6P1
GH12F012846 0.8 ENCODE 11.6 -43.8 -43801 0.2 CTCF KLF1 SAP130 KLF17 SIN3A DMAP1 ZNF48 ZNF335 HIC1 GLIS2 MIR614 GPRC5A GPRC5D RPS6P1 GC12P012841
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR614 on UCSC Golden Path with GeneCards custom track

Promoters for MIR614 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000426662 1418 3201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for MIR614 Gene

Chromosome:
12
Start:
12,890,782 bp from pter
End:
12,917,937 bp from pter
Size:
27,156 bases
Orientation:
Plus strand

Genomic View for MIR614 Gene

Genes around MIR614 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR614 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR614 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR614 Gene

Proteins for MIR614 Gene

  • Protein details for MIR614 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFJ5-RAI3_HUMAN
    Recommended name:
    Retinoic acid-induced protein 3
    Protein Accession:
    Q8NFJ5
    Secondary Accessions:
    • B3KV45
    • O95357

    Protein attributes for MIR614 Gene

    Size:
    357 amino acids
    Molecular mass:
    40251 Da
    Quaternary structure:
    • Interacts (via its transmembrane domain) with EGFR.
    • Interacts (via its transmembrane domain) with EGFR.

neXtProt entry for MIR614 Gene

Post-translational modifications for MIR614 Gene

  • Phosphorylated in two conserved double-tyrosine motifs, TYR-317/TYR-320 and TYR-347/TYR-350, by EGFR; leading to inactivation of the tumor suppressive function of GPRC5A in lung cancer cells. TYR-317 and TYR-320 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation.
  • Ubiquitination at Lys 348 and Lys 353
  • Glycosylation at Asn 158
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR614 Gene

No data available for DME Specific Peptides for MIR614 Gene

Domains & Families for MIR614 Gene

Gene Families for MIR614 Gene

Protein Domains for MIR614 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NFJ5

UniProtKB/Swiss-Prot:

RAI3_HUMAN :
  • Belongs to the G-protein coupled receptor 3 family.
Family:
  • Belongs to the G-protein coupled receptor 3 family.
genes like me logo Genes that share domains with MIR614: view

No data available for Suggested Antigen Peptide Sequences for MIR614 Gene

Function for MIR614 Gene

Molecular function for MIR614 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).
UniProtKB/Swiss-Prot Induction:
By all-trans retinoic acid (ATRA).

Gene Ontology (GO) - Molecular Function for MIR614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA --
genes like me logo Genes that share ontologies with MIR614: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR614 Gene

Localization for MIR614 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR614 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269 PubMed:18000218}.

Gene Ontology (GO) - Cellular Components for MIR614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane TAS --
GO:0005913 cell-cell adherens junction IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR614: view

No data available for Subcellular locations from COMPARTMENTS for MIR614 Gene

Pathways & Interactions for MIR614 Gene

genes like me logo Genes that share pathways with MIR614: view

Pathways by source for MIR614 Gene

Gene Ontology (GO) - Biological Process for MIR614 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS --
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity ISS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with MIR614: view

No data available for SIGNOR curated interactions for MIR614 Gene

Transcripts for MIR614 Gene

mRNA/cDNA for MIR614 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR614 Gene

No ASD Table

Relevant External Links for MIR614 Gene

GeneLoc Exon Structure for
MIR614
ECgene alternative splicing isoforms for
MIR614

Expression for MIR614 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR614 Gene

mRNA differential expression in normal tissues according to GTEx for MIR614 Gene

This gene is overexpressed in Lung (x12.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR614 Gene:

MIR614

mRNA Expression by UniProt/SwissProt for MIR614 Gene:

Q8NFJ5-RAI3_HUMAN
Tissue specificity: Expressed at high level in fetal and adult lung tissues but repressed in most human lung cancers (PubMed:9857033, PubMed:18000218). Constitutively expressed in fetal kidney and adult placenta, kidney, prostate, testis, ovary, small intestine, colon, stomach, and spinal chord at low to moderate levels. Not detectable in fetal heart, brain, and liver and adult heart, brain, liver, skeletal muscle, pancreas, spleen, thymus, and peripheral leukocytes. According to PubMed:10783259, expressed at low but detectable level in pancreas and heart.
genes like me logo Genes that share expression patterns with MIR614: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR614 Gene

Orthologs for MIR614 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR614 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPRC5A 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPRC5A 35
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPRC5A 35
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gprc5a 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPRC5A 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 53 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 52 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii GPRC5A 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToMany
Species where no ortholog for MIR614 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR614 Gene

ENSEMBL:
Gene Tree for MIR614 (if available)
TreeFam:
Gene Tree for MIR614 (if available)

Paralogs for MIR614 Gene

Paralogs for MIR614 Gene

genes like me logo Genes that share paralogs with MIR614: view

Variants for MIR614 Gene

Sequence variations from dbSNP and Humsavar for MIR614 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10845669 -- 12,914,594(+) TTTCT(C/T)TCTCT upstream-variant-2KB
rs11055143 -- 12,914,614(+) tctct(C/T)tcttt upstream-variant-2KB
rs113165777 -- 12,914,514(+) CCCCC(C/T)ACTTT upstream-variant-2KB
rs113419605 -- 12,916,233(+) AGTTG(A/G)TTGAT downstream-variant-500B
rs113863137 -- 12,915,694(+) ACTAT(A/T)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR614 Gene

Variant ID Type Subtype PubMed ID
esv2745567 CNV deletion 23290073
esv3628627 CNV gain 21293372
nsv1159986 CNV deletion 26073780
nsv832333 CNV gain 17160897

Relevant External Links for MIR614 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR614

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR614 Gene

Disorders for MIR614 Gene

Relevant External Links for MIR614

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR614

No disorders were found for MIR614 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR614 Gene

Publications for MIR614 Gene

  1. [MiR-614 inhibited lung cancer cell invasion and proliferation via targeting PSA]. (PMID: 25342037) Lv F. … Xue Q. (Zhongguo Fei Ai Za Zhi 2014) 3 64
  2. EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer. (PMID: 25311788) Lin X. … Deng J. (Mol. Cancer 2014) 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64

Products for MIR614 Gene

Sources for MIR614 Gene

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