Subcategory (RNA class) for MIR614 Gene
Quality Score for this RNA gene is
Aliases for MIR614 Gene
External Ids for MIR614 Gene
Previous HGNC Symbols for MIR614 Gene
Previous GeneCards Identifiers for MIR614 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR614 Gene
MIR614 (MicroRNA 614) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Integrated Pancreatic Cancer Pathway and GPCRs, Class C Metabotropic glutamate, pheromone. An important paralog of this gene is GPRC5D.
UniProtKB/Swiss-Prot for MIR614 Gene
Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling (By similarity). May act as a lung tumor suppressor (PubMed:18000218).