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Aliases for MIR6125 Gene

Subcategory (RNA class) for MIR6125 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR6125 Gene

  • MicroRNA 6125 2 3 5
  • MicroRNA Mir-6125 3
  • Hsa-Mir-6125 3
  • Mir-6125 3

External Ids for MIR6125 Gene

Previous GeneCards Identifiers for MIR6125 Gene

  • GC12U901936

Summaries for MIR6125 Gene

Entrez Gene Summary for MIR6125 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR6125 Gene

MIR6125 (MicroRNA 6125) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Deubiquitination.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR6125 Gene

Genomics for MIR6125 Gene

Regulatory Elements for MIR6125 Gene

Enhancers for MIR6125 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G062263 1.4 FANTOM5 ENCODE dbSUPER 0.7 +4.2 4244 2.8 PKNOX1 ZMYM3 CHD7 POLR2A EGR1 CBX5 STAT2 IKZF2 STAT1 ZNF362 USP15 LINC01465 FAM19A2 MIR6125
GH12G062268 1.3 Ensembl ENCODE dbSUPER 0.4 +8.5 8548 1.4 BCOR ATF1 JUN ZMYM3 RFX5 FOSL1 ZNF121 RCOR1 NFE2 FOS MIR6125 FAM19A2
GH12G062269 0.8 Ensembl dbSUPER 0.4 +6.9 6942 0.2 GATA3 GATA2 BHLHE40 IKZF1 FOS MIR6125 FAM19A2
GH12G062267 0.7 Ensembl dbSUPER 0.4 +7.5 7542 0.2 IKZF1 HMBOX1 MIR6125 FAM19A2
GH12G062270 0.7 dbSUPER 0.4 +10.4 10365 1.1 RNF2 TAL1 DPF2 TCF12 ARID1B PRDM6 ZNF316 NCOR1 SMARCA4 ZSCAN29 USP15 FAM19A2 MIR6125
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR6125 on UCSC Golden Path with GeneCards custom track

Promoters for MIR6125 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052966 241 2801 CREB3L1 AGO1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for MIR6125 Gene

Chromosome:
12
Start:
62,260,359 bp from pter
End:
62,260,454 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR6125 Gene

Genes around MIR6125 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR6125 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR6125 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR6125 Gene

Proteins for MIR6125 Gene

Post-translational modifications for MIR6125 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR6125 Gene

Domains & Families for MIR6125 Gene

Gene Families for MIR6125 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR6125: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR6125 Gene

Function for MIR6125 Gene

Animal Model Products

miRNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR6125 Gene

Localization for MIR6125 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR6125 Gene

Pathways & Interactions for MIR6125 Gene

genes like me logo Genes that share pathways with MIR6125: view

Pathways by source for MIR6125 Gene

Interacting Proteins for MIR6125 Gene

Gene Ontology (GO) - Biological Process for MIR6125 Gene

None

No data available for SIGNOR curated interactions for MIR6125 Gene

Drugs & Compounds for MIR6125 Gene

No Compound Related Data Available

Transcripts for MIR6125 Gene

mRNA/cDNA for MIR6125 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR6125 Gene

No ASD Table

Relevant External Links for MIR6125 Gene

GeneLoc Exon Structure for
MIR6125
ECgene alternative splicing isoforms for
MIR6125

Expression for MIR6125 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR6125 Gene:

MIR6125
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR6125 Gene

Orthologs for MIR6125 Gene

Evolution for MIR6125 Gene

ENSEMBL:
Gene Tree for MIR6125 (if available)
TreeFam:
Gene Tree for MIR6125 (if available)

No data available for Orthologs for MIR6125 Gene

Paralogs for MIR6125 Gene

No data available for Paralogs for MIR6125 Gene

Variants for MIR6125 Gene

Sequence variations from dbSNP and Humsavar for MIR6125 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000029099 -- 62,260,261(+) CGCCC(C/T)CGGGG upstream-variant-2KB
rs1000761729 -- 62,260,751(+) CTGAC(G/T)CGTGC intron-variant, downstream-variant-500B
rs1001367907 -- 62,260,779(+) TTCCT(G/T)CCGTA intron-variant, downstream-variant-500B
rs1001429982 -- 62,258,440(+) TGGAC(A/T)TTAGG upstream-variant-2KB
rs1004962348 -- 62,258,523(+) GCCCC(C/T)AACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR6125 Gene

Variant ID Type Subtype PubMed ID
nsv952195 CNV duplication 24416366

Relevant External Links for MIR6125 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR6125

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR6125 Gene

Disorders for MIR6125 Gene

Relevant External Links for MIR6125

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR6125

No disorders were found for MIR6125 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR6125 Gene

Publications for MIR6125 Gene

  1. Induction of the cellular microRNA, Hs_154, by West Nile virus contributes to virus-mediated apoptosis through repression of antiapoptotic factors. (PMID: 22345437) Smith J.L. … Hirsch A.J. (J. Virol. 2012) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR6125 Gene

Sources for MIR6125 Gene

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