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Aliases for MIR612 Gene

Subcategory (RNA class) for MIR612 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR612 Gene

  • MicroRNA 612 2 3 5
  • Hsa-Mir-612 3
  • MIRN612 3

External Ids for MIR612 Gene

ORGUL Members for MIR612 Gene

Previous HGNC Symbols for MIR612 Gene

  • MIRN612

Previous GeneCards Identifiers for MIR612 Gene

  • GC11P064969
  • GC11P065211
  • GC11P065448
  • GC11P065459
  • GC11P065473
  • GC11P065481
  • GC11P065492
  • GC11P065507
  • GC11P065515

Summaries for MIR612 Gene

Entrez Gene Summary for MIR612 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR612 Gene

MIR612 (MicroRNA 612) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR612 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR612 Gene

Genomics for MIR612 Gene

GeneHancer (GH) Regulatory Elements for MIR612 Gene

Promoters and enhancers for MIR612 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065438 Enhancer 1.4 Ensembl ENCODE dbSUPER 550.8 -0.2 -227 10.7 PKNOX1 CLOCK SMAD1 IRF4 YY1 TCF12 ZNF121 POLR2B GLIS2 E2F8 ENSG00000275948 GC11P065523 GC11P065530 GC11P065531 MIR612 NEAT1 SF1 RELA VPS51 EIF1AD
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.9 +45.6 45626 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065288 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -148.7 -148661 14.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 BRCA1 ZNF48 ETS1 ZNF766 FOS POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11I065510 Enhancer 1.1 ENCODE dbSUPER 11.8 +66.5 66527 1.1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF213 ZNF143 ATF7 RUNX3 RXRA ENSG00000255478 SLC25A45 FRMD8 MIR612 CDC42EP2 EHBP1L1 KCNK7 SNX32 SNRPGP19 ENSG00000274072
GH11I065304 Enhancer 1.1 ENCODE dbSUPER 10.1 -139.0 -138962 2.8 FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 FOS NFYC MXD4 REST DPF2 POLA2 PGAM1P8 CAPN1 LOC728975 MIR612 LOC105369344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR612 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR612 Gene

Genomic Locations for MIR612 Gene
chr11:65,444,458-65,444,557
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr11:65,190,245-65,213,011
(GRCh37/hg19)

Genomic View for MIR612 Gene

Genes around MIR612 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR612 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR612 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR612 Gene

Proteins for MIR612 Gene

Post-translational modifications for MIR612 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR612 Gene

Domains & Families for MIR612 Gene

Gene Families for MIR612 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR612: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR612 Gene

Function for MIR612 Gene

Phenotypes From GWAS Catalog for MIR612 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR612 Gene

Localization for MIR612 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR612 Gene

Pathways & Interactions for MIR612 Gene

SuperPathways for MIR612 Gene

No Data Available

Interacting Proteins for MIR612 Gene

Gene Ontology (GO) - Biological Process for MIR612 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR612 Gene

Drugs & Compounds for MIR612 Gene

No Compound Related Data Available

Transcripts for MIR612 Gene

mRNA/cDNA for MIR612 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR612 Gene

No ASD Table

Relevant External Links for MIR612 Gene

GeneLoc Exon Structure for
MIR612
ECgene alternative splicing isoforms for
MIR612

Expression for MIR612 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR612 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR612 Gene:

MIR612
genes like me logo Genes that share expression patterns with MIR612: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR612 Gene

Orthologs for MIR612 Gene

Evolution for MIR612 Gene

ENSEMBL:
Gene Tree for MIR612 (if available)
TreeFam:
Gene Tree for MIR612 (if available)

No data available for Orthologs for MIR612 Gene

Paralogs for MIR612 Gene

No data available for Paralogs for MIR612 Gene

Variants for MIR612 Gene

Sequence variations from dbSNP and Humsavar for MIR612 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001372670 -- 65,443,313(+) T/C upstream_transcript_variant
rs1003049498 -- 65,443,853(+) C/T upstream_transcript_variant
rs1003083914 -- 65,443,646(+) G/C upstream_transcript_variant
rs1003662439 -- 65,444,129(+) C/T upstream_transcript_variant
rs1004276812 -- 65,444,168(+) A/ upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR612 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680

Additional Variant Information for MIR612 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR612

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR612 Gene

Disorders for MIR612 Gene

Additional Disease Information for MIR612

No disorders were found for MIR612 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR612 Gene

Publications for MIR612 Gene

  1. miR-612 suppresses stem cell-like property of hepatocellular carcinoma cells by modulating Sp1/Nanog signaling. (PMID: 27685621) Liu Y … Wu WZ (Cell death & disease 2016) 3 58
  2. miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. (PMID: 26158514) Sheng L … Feng Q (Cell death & disease 2015) 3 58
  3. Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility. (PMID: 24618566) Gutierrez-Camino A … Garcia-Orad A (Pediatric research 2014) 3 58
  4. MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. (PMID: 24704424) Tang J … Wu WZ (Biochemical and biophysical research communications 2014) 3 58
  5. miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma. (PMID: 23478189) Tao ZH … Wu WZ (The Journal of experimental medicine 2013) 3 58

Products for MIR612 Gene

Sources for MIR612 Gene

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