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Aliases for MIR612 Gene

Subcategory (RNA class) for MIR612 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR612 Gene

  • MicroRNA 612 2 3
  • Nuclear Paraspeckle Assembly Transcript 1 (Non-Protein Coding) 5
  • Hsa-Mir-612 3
  • MIRN612 3
  • NEAT1 5

External Ids for MIR612 Gene

Previous HGNC Symbols for MIR612 Gene

  • MIRN612

Previous GeneCards Identifiers for MIR612 Gene

  • GC11P064969
  • GC11P065211
  • GC11P065448
  • GC11P065459
  • GC11P065473
  • GC11P065481

Summaries for MIR612 Gene

Entrez Gene Summary for MIR612 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR612 Gene

MIR612 (MicroRNA 612) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR612 Gene

Genomics for MIR612 Gene

Regulatory Elements for MIR612 Gene

Enhancers for MIR612 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065470 2.1 VISTA FANTOM5 Ensembl ENCODE 13.5 +67.3 67310 40.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 LOC105369353 LOC105369352 KAT5 SSSCA1-AS1 NEAT1 ZFPL1 EIF1AD EHBP1L1 MRPL11 POLA2
GH11F065375 0.8 ENCODE 12 -47.6 -47550 0.2 ZNF316 TIGD3 MIR612 CDC42EP2 ENSG00000255478 SLC25A45
GH11F065510 0.2 ENCODE 11.7 +88.2 88212 1.1 ELF3 HDAC1 ATF1 CBX3 PKNOX1 ARNT ARID4B SIN3A ZSCAN9 RAD21 ENSG00000255478 SLC25A45 FRMD8 MIR612 CDC42EP2 EHBP1L1 KCNK7 SNX32 ENSG00000274072 SNRPGP19
GH11F065400 0.6 ENCODE 11.4 -21.3 -21347 2.4 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A ARID4B ZNF48 JUNB NCOA1 NEAT1 ENSG00000255478 MIR612 TIGD3 LOC728975 BANF1 FRMD8 GC11P065418
GH11F065304 1 Ensembl ENCODE 10.1 -117.3 -117279 2.8 HDGF ARID4B DMAP1 ZNF48 SLC30A9 FOS NFYC MXD4 PPARG KAT8 DPF2 POLA2 PGAM1P8 CAPN1 LOC728975 MIR612 LOC105369344
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR612 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR612 Gene

Chromosome:
11
Start:
65,422,774 bp from pter
End:
65,445,540 bp from pter
Size:
22,767 bases
Orientation:
Plus strand

Genomic View for MIR612 Gene

Genes around MIR612 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR612 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR612 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR612 Gene

Proteins for MIR612 Gene

Post-translational modifications for MIR612 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR612 Gene

Domains & Families for MIR612 Gene

Gene Families for MIR612 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR612: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR612 Gene

Function for MIR612 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR612 Gene

Localization for MIR612 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR612 Gene

Pathways & Interactions for MIR612 Gene

SuperPathways for MIR612 Gene

No Data Available

Interacting Proteins for MIR612 Gene

Gene Ontology (GO) - Biological Process for MIR612 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR612 Gene

Transcripts for MIR612 Gene

mRNA/cDNA for MIR612 Gene

(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR612 Gene

No ASD Table

Relevant External Links for MIR612 Gene

GeneLoc Exon Structure for
MIR612
ECgene alternative splicing isoforms for
MIR612

Expression for MIR612 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR612 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR612 Gene:

MIR612
genes like me logo Genes that share expression patterns with MIR612: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR612 Gene

Orthologs for MIR612 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR612 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-612 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR612 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR612 Gene

ENSEMBL:
Gene Tree for MIR612 (if available)
TreeFam:
Gene Tree for MIR612 (if available)

Paralogs for MIR612 Gene

No data available for Paralogs for MIR612 Gene

Variants for MIR612 Gene

Sequence variations from dbSNP and Humsavar for MIR612 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1075692 -- 65,444,976(+) CTTAG(A/G)TTCCC nc-transcript-variant, downstream-variant-500B
rs112438939 -- 65,442,625(+) GCCTG(-/T)AATCT nc-transcript-variant, upstream-variant-2KB
rs112898102 -- 65,443,117(+) ATTTT(A/G)TTGGT nc-transcript-variant, upstream-variant-2KB
rs113097505 -- 65,442,473(+) GCCTG(-/A)AGTCA nc-transcript-variant, upstream-variant-2KB
rs114066536 -- 65,442,899(+) ACTTT(A/G)TCTTA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR612 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680

Relevant External Links for MIR612 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR612

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR612 Gene

Disorders for MIR612 Gene

Relevant External Links for MIR612

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR612

No disorders were found for MIR612 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR612 Gene

Publications for MIR612 Gene

  1. miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. (PMID: 26158514) Sheng L. … Feng Q. (Cell Death Dis 2015) 3 64
  2. MiR-612 suppresses the stemness of liver cancer via Wnt/I^-catenin signaling. (PMID: 24704424) Tang J. … Wu W.Z. (Biochem. Biophys. Res. Commun. 2014) 3 64
  3. Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility. (PMID: 24618566) Gutierrez-Camino A. … Garcia-Orad A. (Pediatr. Res. 2014) 3 64
  4. miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma. (PMID: 23478189) Tao Z.H. … Wu W.Z. (J. Exp. Med. 2013) 3 64
  5. Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms. (PMID: 23077621) Kim H.K. … Chanock S.J. (PLoS ONE 2012) 3 64

Products for MIR612 Gene

Sources for MIR612 Gene

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