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Aliases for MIR612 Gene

Subcategory (RNA class) for MIR612 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR612 Gene

  • MicroRNA 612 2 3 5
  • Hsa-Mir-612 3
  • MIRN612 3

External Ids for MIR612 Gene

ORGUL Members for MIR612 Gene

Previous HGNC Symbols for MIR612 Gene

  • MIRN612

Previous GeneCards Identifiers for MIR612 Gene

  • GC11P064969
  • GC11P065211
  • GC11P065448
  • GC11P065459
  • GC11P065473
  • GC11P065481
  • GC11P065492
  • GC11P065507

Summaries for MIR612 Gene

Entrez Gene Summary for MIR612 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR612 Gene

MIR612 (MicroRNA 612) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR612 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR612 Gene

Genomics for MIR612 Gene

Regulatory Elements for MIR612 Gene

Enhancers for MIR612 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065470 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.8 +45.6 45626 39 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MCM3 SF1 ZFPL1 POLA2 LOC105369352 SART1 PCNX3 EIF1AD KAT5 SF3B2 MUS81
GH11H065288 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 -148.7 -148661 14 PKNOX1 FOXA2 ATF1 ARID4B SIN3A DMAP1 BRCA1 ZNF766 FOS RUNX3 POLA2 EHD1 LOC728975 SLC25A45 DPF2 FRMD8 ENSG00000255478 SPDYC CAPN1 PGAM1P8
GH11H065510 1.2 ENCODE dbSUPER 11.7 +66.5 66528 1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 ATF7 RUNX3 MXD4 REST ENSG00000255478 SLC25A45 FRMD8 MIR612 CDC42EP2 EHBP1L1 KCNK7 SNX32 ENSG00000274072 SNRPGP19
GH11H065304 1.2 ENCODE dbSUPER 10 -139.0 -138963 2 FOXA2 ARID4B DMAP1 YY1 SLC30A9 FOS MXD4 NFYC REST PPARG DPF2 POLA2 PGAM1P8 CAPN1 LOC728975 MIR612 LOC105369344
GH11H065400 1 ENCODE dbSUPER 11.4 -43.0 -43031 2 SOX5 SOX13 MAZ KLF1 FOXA2 SAP130 FOXA3 ARID4B ZNF384 RARA NEAT1 ENSG00000255478 TIGD3 MIR612 LOC728975 BANF1 FRMD8 GC11P065418
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR612 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR612 Gene

Chromosome:
11
Start:
65,444,458 bp from pter
End:
65,444,557 bp from pter
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR612 Gene

Genes around MIR612 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR612 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR612 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR612 Gene

Proteins for MIR612 Gene

Post-translational modifications for MIR612 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR612 Gene

Domains & Families for MIR612 Gene

Gene Families for MIR612 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR612: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR612 Gene

Function for MIR612 Gene

Phenotypes From GWAS Catalog for MIR612 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR612
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR612 Gene

Localization for MIR612 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR612 Gene

Pathways & Interactions for MIR612 Gene

SuperPathways for MIR612 Gene

No Data Available

Interacting Proteins for MIR612 Gene

Gene Ontology (GO) - Biological Process for MIR612 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR612 Gene

Drugs & Compounds for MIR612 Gene

No Compound Related Data Available

Transcripts for MIR612 Gene

mRNA/cDNA for MIR612 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR612
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR612 Gene

No ASD Table

Relevant External Links for MIR612 Gene

GeneLoc Exon Structure for
MIR612
ECgene alternative splicing isoforms for
MIR612

Expression for MIR612 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR612 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR612 Gene:

MIR612
genes like me logo Genes that share expression patterns with MIR612: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR612 Gene

Orthologs for MIR612 Gene

Evolution for MIR612 Gene

ENSEMBL:
Gene Tree for MIR612 (if available)
TreeFam:
Gene Tree for MIR612 (if available)

No data available for Orthologs for MIR612 Gene

Paralogs for MIR612 Gene

No data available for Paralogs for MIR612 Gene

Variants for MIR612 Gene

Sequence variations from dbSNP and Humsavar for MIR612 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1001372670 -- 65,443,313(+) CTGTG(C/T)CTGGT nc-transcript-variant, upstream-variant-2KB
rs1003049498 -- 65,443,853(+) GAAGC(C/T)AGTGG nc-transcript-variant, upstream-variant-2KB
rs1003083914 -- 65,443,646(+) CTACA(C/G)TCACA nc-transcript-variant, upstream-variant-2KB
rs1003662439 -- 65,444,129(+) ATGGA(C/T)GTGTG nc-transcript-variant, upstream-variant-2KB
rs1004276812 -- 65,444,168(+) GGGGG(-/A)GGGGG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR612 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv526181 CNV gain 19592680

Relevant External Links for MIR612 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR612

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR612 Gene

Disorders for MIR612 Gene

Relevant External Links for MIR612

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR612

No disorders were found for MIR612 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR612 Gene

Publications for MIR612 Gene

  1. miR-612 negatively regulates colorectal cancer growth and metastasis by targeting AKT2. (PMID: 26158514) Sheng L … Feng Q (Cell death & disease 2015) 3 60
  2. MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. (PMID: 24704424) Tang J … Wu WZ (Biochemical and biophysical research communications 2014) 3 60
  3. Noncoding RNA-related polymorphisms in pediatric acute lymphoblastic leukemia susceptibility. (PMID: 24618566) Gutierrez-Camino A … Garcia-Orad A (Pediatric research 2014) 3 60
  4. miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma. (PMID: 23478189) Tao ZH … Wu WZ (The Journal of experimental medicine 2013) 3 60
  5. Common genetic variants in miR-1206 (8q24.2) and miR-612 (11q13.3) affect biogenesis of mature miRNA forms. (PMID: 23077621) Kim HK … Chanock SJ (PloS one 2012) 3 60

Products for MIR612 Gene

Sources for MIR612 Gene

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