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Aliases for MIR611 Gene

Subcategory (RNA class) for MIR611 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR611 Gene

  • MicroRNA 611 2 3
  • TMEM258 4 5
  • Transmembrane Protein 258 5
  • Hsa-Mir-611 3
  • C11orf10 4
  • MIRN611 3

External Ids for MIR611 Gene

Previous HGNC Symbols for MIR611 Gene

  • MIRN611

Previous GeneCards Identifiers for MIR611 Gene

  • GC11M061318
  • GC11M061559

Summaries for MIR611 Gene

Entrez Gene Summary for MIR611 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR611 Gene

MIR611 (MicroRNA 611) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR611 Gene

Genomics for MIR611 Gene

Regulatory Elements for MIR611 Gene

Enhancers for MIR611 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F061731 1 Ensembl ENCODE 11.6 +59.8 59834 2.1 ATF1 PKNOX1 ARID4B SIN3A ZNF48 BRCA1 ZNF143 DEK MXD4 REST DAGLA MYRF DKFZP434K028 MIR611 TMEM258 FEN1 SYT7 PIR41833
GH11F061819 0.9 Ensembl ENCODE 10.7 -27.8 -27765 1.7 CTCF KLF1 PKNOX1 ZNF316 ZFHX2 POLR2A SCRT2 HNF4G NFE2 ZNF600 FADS2 MIR611 FEN1 TMEM258 PIR43939
GH11F061791 1.1 ENCODE 10.4 +0.1 77 3.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 FADS2 LRRN4CL TMEM109 FADS1 MIR1908 EEF1G TAF6L BEST1 MIR611 AHNAK
GH11F061680 1.1 ENCODE 9.8 +112.3 112323 1.1 ARID4B SIN3A ZNF48 GLIS2 ZNF207 ZNF143 GTF2B MXD4 REST SREBF1 MTA2 TMEM138 B3GAT3 EML3 TMEM109 INTS5 METTL12 UBXN1 AHNAK MIR611
GH11F061910 0.8 Ensembl ENCODE 9.8 -118.9 -118907 3.4 ARID4B SIN3A ZNF143 ZNF207 ZNF263 REST SMARCA4 RFX3 ETV4 GLIS1 B3GAT3 TMEM109 BEST1 RAB3IL1 FADS1 MIR1908 LRRN4CL FTH1 AHNAK MIR611
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR611 on UCSC Golden Path with GeneCards custom track

Promoters for MIR611 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109544 2 2801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143

Genomic Location for MIR611 Gene

Chromosome:
11
Start:
61,768,501 bp from pter
End:
61,792,802 bp from pter
Size:
24,302 bases
Orientation:
Minus strand

Genomic View for MIR611 Gene

Genes around MIR611 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR611 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR611 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR611 Gene

Proteins for MIR611 Gene

  • Protein details for MIR611 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61165-TM258_HUMAN
    Recommended name:
    Transmembrane protein 258
    Protein Accession:
    P61165
    Secondary Accessions:
    • A8K6L8
    • Q9D953
    • Q9Y2Q7

    Protein attributes for MIR611 Gene

    Size:
    79 amino acids
    Molecular mass:
    9079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR611 Gene

Post-translational modifications for MIR611 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR611 Gene

No data available for DME Specific Peptides for MIR611 Gene

Domains & Families for MIR611 Gene

Gene Families for MIR611 Gene

Protein Domains for MIR611 Gene

Graphical View of Domain Structure for InterPro Entry

P61165

UniProtKB/Swiss-Prot:

TM258_HUMAN :
  • Belongs to the TMEM258 family.
Family:
  • Belongs to the TMEM258 family.
genes like me logo Genes that share domains with MIR611: view

No data available for Suggested Antigen Peptide Sequences for MIR611 Gene

Function for MIR611 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR611 Gene

Localization for MIR611 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR611 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR611 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR611: view

No data available for Subcellular locations from COMPARTMENTS for MIR611 Gene

Pathways & Interactions for MIR611 Gene

SuperPathways for MIR611 Gene

No Data Available

Interacting Proteins for MIR611 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000257262%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: P61165-TM258_HUMAN ENSP00000257262 for MIR611 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MIR611 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR611 Gene

Transcripts for MIR611 Gene

mRNA/cDNA for MIR611 Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR611 Gene

No ASD Table

Relevant External Links for MIR611 Gene

GeneLoc Exon Structure for
MIR611
ECgene alternative splicing isoforms for
MIR611

Expression for MIR611 Gene

mRNA expression in normal human tissues for MIR611 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR611 Gene:

MIR611
genes like me logo Genes that share expression patterns with MIR611: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR611 Gene

Orthologs for MIR611 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR611 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Tmem258 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM258 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM258 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM258 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 99 (a)
OneToMany
C11ORF10 35
  • 90 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMEM258 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM258 35
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM258 35
  • 99 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem258 35
  • 92 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9669 35
  • 65 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y57E12AM.1 35
  • 53 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8385 35
  • 65 (a)
OneToOne
Species where no ortholog for MIR611 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR611 Gene

ENSEMBL:
Gene Tree for MIR611 (if available)
TreeFam:
Gene Tree for MIR611 (if available)

Paralogs for MIR611 Gene

Pseudogenes.org Pseudogenes for MIR611 Gene

genes like me logo Genes that share paralogs with MIR611: view

No data available for Paralogs for MIR611 Gene

Variants for MIR611 Gene

Sequence variations from dbSNP and Humsavar for MIR611 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111585800 -- 61,792,554(+) CTCTC(A/C/T)CCATT nc-transcript-variant, upstream-variant-2KB, splice-donor-variant
rs117731621 -- 61,793,232(+) TATGG(G/T)GTCGT intron-variant, upstream-variant-2KB
rs139748600 -- 61,793,862(+) AAGAA(A/T)TGAAC intron-variant, upstream-variant-2KB
rs141352993 -- 61,792,712(+) AGGGG(C/T)CTGCG upstream-variant-2KB, utr-variant-5-prime
rs143036029 -- 61,792,702(+) TAGAG(G/T)GAGCA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR611 Gene

Variant ID Type Subtype PubMed ID
nsv343 CNV insertion 18451855
nsv528697 CNV loss 19592680

Relevant External Links for MIR611 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR611

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR611 Gene

Disorders for MIR611 Gene

Relevant External Links for MIR611

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR611

No disorders were found for MIR611 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR611 Gene

Publications for MIR611 Gene

  1. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3 64
  2. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 4 64
  3. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P. … Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012) 4 64
  4. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PMID: 21829377) Lemaitre R.N. … Steffen L.M. (PLoS Genet. 2011) 3 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR611 Gene

Sources for MIR611 Gene

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