Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR608 Gene

Subcategory (RNA class) for MIR608 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR608 Gene

  • MicroRNA 608 2 3 5
  • Hsa-Mir-608 3
  • MIRN608 3

External Ids for MIR608 Gene

ORGUL Members for MIR608 Gene

Previous HGNC Symbols for MIR608 Gene

  • MIRN608

Previous GeneCards Identifiers for MIR608 Gene

  • GC10P102725
  • GC10P102736

Summaries for MIR608 Gene

Entrez Gene Summary for MIR608 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR608 Gene

MIR608 (MicroRNA 608) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR608 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR608 Gene

Genomics for MIR608 Gene

GeneHancer (GH) Regulatory Elements for MIR608 Gene

Promoters and enhancers for MIR608 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I100995 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +24.3 24319 7.4 HDGF SMAD1 ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LZTS2 MRPL43 SEMA4G MIR608 ENSG00000272572 KCNIP2 PDZD7
GH10I100909 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.7 -63.0 -63020 4.8 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ENSG00000272572 SLF2 MRPL43 TWNK CWF19L1 CHUK POLL PHBP9 SEMA4G MIR608
GH10I101030 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 +58.3 58262 6.4 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 FOS PDZD7 SFXN3 MRPL43 TWNK KAZALD1 TLX1 TLX1NB SEMA4G ENSG00000236662 MIR608
GH10I100939 Enhancer 0.3 ENCODE 11.8 -35.0 -35006 0.2 PRDM1 SEMA4G SLF2 MIR608 TWNK MRPL43 ENSG00000236662 ENSG00000272572 ENSG00000273476
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR608 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR608 Gene

Genomic Locations for MIR608 Gene
chr10:100,974,985-100,975,084
(GRCh38/hg38)
Size:
100 bases
Orientation:
Plus strand
chr10:102,734,742-102,734,841
(GRCh37/hg19)

Genomic View for MIR608 Gene

Genes around MIR608 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR608 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR608 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR608 Gene

Proteins for MIR608 Gene

Post-translational modifications for MIR608 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR608 Gene

Domains & Families for MIR608 Gene

Gene Families for MIR608 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR608: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR608 Gene

Function for MIR608 Gene

Phenotypes From GWAS Catalog for MIR608 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR608 Gene

Localization for MIR608 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR608 Gene

Pathways & Interactions for MIR608 Gene

SuperPathways for MIR608 Gene

No Data Available

Interacting Proteins for MIR608 Gene

Gene Ontology (GO) - Biological Process for MIR608 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR608 Gene

Drugs & Compounds for MIR608 Gene

No Compound Related Data Available

Transcripts for MIR608 Gene

mRNA/cDNA for MIR608 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR608 Gene

No ASD Table

Relevant External Links for MIR608 Gene

GeneLoc Exon Structure for
MIR608
ECgene alternative splicing isoforms for
MIR608

Expression for MIR608 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR608 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR608 Gene:

MIR608
genes like me logo Genes that share expression patterns with MIR608: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR608 Gene

Orthologs for MIR608 Gene

Evolution for MIR608 Gene

ENSEMBL:
Gene Tree for MIR608 (if available)
TreeFam:
Gene Tree for MIR608 (if available)

No data available for Orthologs for MIR608 Gene

Paralogs for MIR608 Gene

No data available for Paralogs for MIR608 Gene

Variants for MIR608 Gene

Sequence variations from dbSNP and Humsavar for MIR608 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1007038634 -- 100,973,225(+) G/A/C/T upstream_transcript_variant
rs1007617473 -- 100,974,128(+) G/A upstream_transcript_variant
rs1008017804 -- 100,975,243(+) G/A downstream_transcript_variant
rs1008083937 -- 100,973,840(+) A/G upstream_transcript_variant
rs1009508320 -- 100,975,476(+) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR608 Gene

Variant ID Type Subtype PubMed ID
esv3624366 CNV loss 21293372
nsv467443 CNV loss 19166990
nsv517698 CNV loss 19592680
nsv552051 CNV loss 21841781
nsv831965 CNV loss 17160897

Additional Variant Information for MIR608 Gene

Human Gene Mutation Database (HGMD)
MIR608
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR608

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR608 Gene

Disorders for MIR608 Gene

Additional Disease Information for MIR608

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR608 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR608 Gene

Publications for MIR608 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  4. MiR-608 regulating the expression of ribonucleotide reductase M1 and cytidine deaminase is repressed through induced gemcitabine chemoresistance in pancreatic cancer cells. (PMID: 28887583) Rajabpour A … Teimoori-Toolabi L (Cancer chemotherapy and pharmacology 2017) 3 58
  5. A meta-analysis: Is there any association between MiR-608 rs4919510 polymorphism and breast cancer risks? (PMID: 28829821) Wang J … Gao J (PloS one 2017) 3 58

Products for MIR608 Gene

Sources for MIR608 Gene

Content
Loading form....