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Aliases for MIR605 Gene

Subcategory (RNA class) for MIR605 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR605 Gene

  • MicroRNA 605 2 3 5
  • Hsa-Mir-605 3
  • Mir-605 3
  • MIRN605 3

External Ids for MIR605 Gene

ORGUL Members for MIR605 Gene

Previous HGNC Symbols for MIR605 Gene

  • MIRN605

Previous GeneCards Identifiers for MIR605 Gene

  • GC10P052730
  • GC10P053059

Summaries for MIR605 Gene

Entrez Gene Summary for MIR605 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR605 Gene

MIR605 (MicroRNA 605) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR605 include Li-Fraumeni Syndrome.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR605 Gene

Genomics for MIR605 Gene

Regulatory Elements for MIR605 Gene

Enhancers for MIR605 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G051366 0.6 dbSUPER 10.5 +67.9 67926 3.0 CTCF TEAD1 ZNF547 FEZF1 ATF2 TEAD3 MIR605 ENSG00000231132 RSU1P3 GC10P051555
GH10G051322 0.5 ENCODE 11.7 +22.7 22663 0.2 GATA3 CEBPA CEBPB CEBPG PRDM1 MIR605 ENSG00000231132 RSU1P3 GC10P051555
GH10G051300 0.8 Ensembl ENCODE 0.7 +1.6 1589 2.3 JUND SCRT2 PRDM4 ATF2 NR2F2 ENSG00000231132 MIR605 ENSG00000235279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR605 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR605 Gene

Chromosome:
10
Start:
51,299,573 bp from pter
End:
51,299,655 bp from pter
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR605 Gene

Genes around MIR605 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR605 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR605 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR605 Gene

Proteins for MIR605 Gene

Post-translational modifications for MIR605 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR605 Gene

Domains & Families for MIR605 Gene

Gene Families for MIR605 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR605: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR605 Gene

Function for MIR605 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR605 Gene

Localization for MIR605 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR605 Gene

Pathways & Interactions for MIR605 Gene

SuperPathways for MIR605 Gene

No Data Available

Interacting Proteins for MIR605 Gene

Gene Ontology (GO) - Biological Process for MIR605 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR605 Gene

Drugs & Compounds for MIR605 Gene

No Compound Related Data Available

Transcripts for MIR605 Gene

mRNA/cDNA for MIR605 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR605 Gene

No ASD Table

Relevant External Links for MIR605 Gene

GeneLoc Exon Structure for
MIR605
ECgene alternative splicing isoforms for
MIR605

Expression for MIR605 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR605 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR605 Gene:

MIR605
genes like me logo Genes that share expression patterns with MIR605: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR605 Gene

Orthologs for MIR605 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR605 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-605 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR605 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR605 Gene

ENSEMBL:
Gene Tree for MIR605 (if available)
TreeFam:
Gene Tree for MIR605 (if available)

Paralogs for MIR605 Gene

No data available for Paralogs for MIR605 Gene

Variants for MIR605 Gene

Sequence variations from dbSNP and Humsavar for MIR605 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1001737386 -- 51,299,687(+) CAGGC(C/T)GACAG intron-variant, downstream-variant-500B
rs1001760782 -- 51,298,026(+) TGTAC(C/T)TAACC intron-variant, upstream-variant-2KB
rs1006323749 -- 51,297,684(+) TACAA(C/T)CTAAT intron-variant, upstream-variant-2KB
rs1007541785 -- 51,298,216(+) AAATG(A/T)TACAT intron-variant, upstream-variant-2KB
rs1007950700 -- 51,298,689(+) AACAT(C/T)AGATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR605 Gene

Variant ID Type Subtype PubMed ID
nsv1036645 CNV gain 25217958
nsv831874 CNV gain 17160897

Relevant External Links for MIR605 Gene

Human Gene Mutation Database (HGMD)
MIR605
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR605

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR605 Gene

Disorders for MIR605 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR605 Gene - From: GeneCards

Disorder Aliases PubMed IDs
li-fraumeni syndrome
  • li-fraumeni familiar cancer susceptibility syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR605

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR605
genes like me logo Genes that share disorders with MIR605: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR605 Gene

Publications for MIR605 Gene

  1. Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case-control study. (PMID: 27515039) Miao L. … Ma H. (Chin J Cancer 2016) 3 64
  2. A functional variant in miR-605 modifies the age of onset in Li-Fraumeni syndrome. (PMID: 25683625) Id Said B. … Malkin D. (Cancer Genet 2015) 3 64
  3. Genetic variants in microRNAs and microRNA target sites predict biochemical recurrence after radical prostatectomy in localized prostate cancer. (PMID: 24740842) Huang S.P. … Bao B.Y. (Int. J. Cancer 2014) 3 64
  4. MiR-605 represses PSMD10/Gankyrin and inhibits intrahepatic cholangiocarcinoma cell progression. (PMID: 25131931) Li J. … Wang S. (FEBS Lett. 2014) 3 64
  5. Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk. (PMID: 21976437) Zhang M.W. … Chen K. (Mol. Carcinog. 2012) 3 64

Products for MIR605 Gene

Sources for MIR605 Gene

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