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Aliases for MIR604 Gene

Subcategory (RNA class) for MIR604 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR604 Gene

  • MicroRNA 604 2 3 5
  • Hsa-Mir-604 3
  • MIRN604 3

External Ids for MIR604 Gene

Previous HGNC Symbols for MIR604 Gene

  • MIRN604

Previous GeneCards Identifiers for MIR604 Gene

  • GC10M029874
  • GC10M029852

Summaries for MIR604 Gene

Entrez Gene Summary for MIR604 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR604 Gene

MIR604 (MicroRNA 604) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR604 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR604

Additional gene information for MIR604 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR604 Gene

Genomics for MIR604 Gene

Regulatory Elements for MIR604 Gene

Enhancers for MIR604 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H029582 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -41.9 -41857 8 PKNOX1 RAD21 SCRT2 ZNF143 FOS RCOR1 EGR2 SMARCA5 ZNF654 ZNF280D SVIL MIR604 CKS1BP2 RNU6-908P SVIL-AS1 ENSG00000212411 MIR938
GH10H029617 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -74.6 -74636 4 FOXA2 RAD21 RARA ZNF366 FOS CREM ZNF362 SP5 CEBPB REST MTPAP MIR604 GC10M029917 GC10M029909
GH10H029628 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -84.9 -84933 2 SMARCE1 ZNF687 NFIB MNT CEBPG PAX8 DPF2 FOXA1 ZNF217 CTBP1 SVIL RNU6-908P MIR604 GC10M029917 GC10M029909
GH10H029690 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -147.2 -147199 2 INSM2 FEZF1 ZNF2 GLIS2 ZNF302 ZNF366 ZSCAN5C ZNF391 SP3 CEBPB SVIL ENSG00000259994 MIR604 GC10P029701 GC10M029909
GH10H029679 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10 -136.6 -136606 4 ZBTB11 ZSCAN4 MAX ZBTB40 ZIC2 GABPA GATA3 POLR2A ZNF600 MYC SVIL RNU6-908P MIR604 GC10P029701 GC10M029909
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR604 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR604 Gene

Chromosome:
10
Start:
29,545,004 bp from pter
End:
29,545,097 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR604 Gene

Genes around MIR604 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR604 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR604 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR604 Gene

ORGUL Member Location for MIR604 Gene

ORGUL Member Location for MIR604 gene

Proteins for MIR604 Gene

Post-translational modifications for MIR604 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR604 Gene

Domains & Families for MIR604 Gene

Gene Families for MIR604 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR604: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR604 Gene

Function for MIR604 Gene

Phenotypes From GWAS Catalog for MIR604 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR604
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR604 Gene

Localization for MIR604 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR604 Gene

Pathways & Interactions for MIR604 Gene

SuperPathways for MIR604 Gene

No Data Available

Interacting Proteins for MIR604 Gene

Gene Ontology (GO) - Biological Process for MIR604 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR604 Gene

Drugs & Compounds for MIR604 Gene

No Compound Related Data Available

Transcripts for MIR604 Gene

fRNAdb Secondary structures for MIR604 Gene

  • hsa-mir-604_MI0003617_Homo_sapiens_miR-604_stem-loop_hairpin

mRNA/cDNA for MIR604 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR604
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR604 Gene

No ASD Table

Relevant External Links for MIR604 Gene

GeneLoc Exon Structure for
MIR604
ECgene alternative splicing isoforms for
MIR604

Expression for MIR604 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR604 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR604 Gene:

MIR604
genes like me logo Genes that share expression patterns with MIR604: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR604 Gene

Orthologs for MIR604 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR604 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-604 34
  • 97 (a)
OneToOne
Species where no ortholog for MIR604 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR604 Gene

ENSEMBL:
Gene Tree for MIR604 (if available)
TreeFam:
Gene Tree for MIR604 (if available)

Paralogs for MIR604 Gene

No data available for Paralogs for MIR604 Gene

Variants for MIR604 Gene

Sequence variations from dbSNP and Humsavar for MIR604 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000780628 -- 29,546,803(+) AGAAC(A/C)AAATG intron-variant, upstream-variant-2KB
rs1001944972 -- 29,546,744(+) TTCAT(A/G)AGTGT intron-variant, upstream-variant-2KB
rs1002285213 -- 29,545,872(+) AAAAA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs1002577088 -- 29,544,892(+) ACAGG(C/G/T)GTTTG intron-variant, downstream-variant-500B
rs1002731038 -- 29,546,693(+) GTGCT(C/G/T)ACATT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR604 Gene

Variant ID Type Subtype PubMed ID
nsv1038080 CNV gain 25217958
nsv1129323 OTHER inversion 24896259
nsv831819 CNV loss 17160897

Relevant External Links for MIR604 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR604

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR604 Gene

Disorders for MIR604 Gene

Relevant External Links for MIR604

Genetic Association Database (GAD)
MIR604
Human Genome Epidemiology (HuGE) Navigator
MIR604
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR604

No disorders were found for MIR604 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR604 Gene

Publications for MIR604 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 45 60
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 45 60
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 45 60
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 60
  5. Association of polymorphism in microRNA 604 with susceptibility to persistent hepatitis B virus infection and development of hepatocellular carcinoma. (PMID: 25408584) Cheong JY … Kim YJ (Journal of Korean medical science 2014) 3 60

Products for MIR604 Gene

Sources for MIR604 Gene

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