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Aliases for MIR601 Gene

Subcategory (RNA class) for MIR601 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR601 Gene

  • MicroRNA 601 2 3 5
  • Hsa-Mir-601 3
  • MIRN601 3

External Ids for MIR601 Gene

Previous HGNC Symbols for MIR601 Gene

  • MIRN601

Previous GeneCards Identifiers for MIR601 Gene

  • GC09M125205
  • GC09M126164

Summaries for MIR601 Gene

Entrez Gene Summary for MIR601 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR601 Gene

MIR601 (MicroRNA 601) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR601 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR601

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR601 Gene

Genomics for MIR601 Gene

Regulatory Elements for MIR601 Gene

Enhancers for MIR601 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F123375 1.2 Ensembl ENCODE 12.6 +26.5 26491 1.3 KLF1 SAP130 KLF17 FEZF1 ZIC2 PATZ1 SCRT2 ZNF600 E2F6 TCF7L2 CRB2 MIR601 DENND1A STRBP GC09P123401
GH09F123377 0.4 ENCODE 12.6 +25.1 25127 0.2 KLF1 MAZ ZNF687 RFX1 PKNOX1 KLF17 MNT DPF2 ZFHX2 GATA3 MIR601 DENND1A CRB2 GC09P123401
GH09F123373 0.6 ENCODE 12.6 +28.3 28277 1.1 GATA3 RNF2 POLR2A TAL1 ZNF341 IKZF1 MIR601 DENND1A CRB2 GC09P123401
GH09F123422 0.8 ENCODE 12.5 -20.5 -20524 0.6 MIR601 DENND1A GC09P123406 MIR7150
GH09F123355 1.3 Ensembl ENCODE 12.4 +44.1 44083 6.2 HDGF ATF1 CREB3L1 MLX ZFP64 ARID4B ZNF48 GLIS2 GATA2 KDM4B STRBP MIR601 DENND1A MIR600 MIR600HG CRB2 GC09P123401
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR601 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR601 Gene

Chromosome:
9
Start:
123,402,525 bp from pter
End:
123,402,603 bp from pter
Size:
79 bases
Orientation:
Minus strand

Genomic View for MIR601 Gene

Genes around MIR601 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR601 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR601 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR601 Gene

ORGUL Member Location for MIR601 Gene

ORGUL Member Location for MIR601 gene

Proteins for MIR601 Gene

Post-translational modifications for MIR601 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR601 Gene

Domains & Families for MIR601 Gene

Gene Families for MIR601 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR601: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR601 Gene

Function for MIR601 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR601 Gene

Localization for MIR601 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR601 Gene

Pathways & Interactions for MIR601 Gene

SuperPathways for MIR601 Gene

No Data Available

Interacting Proteins for MIR601 Gene

Gene Ontology (GO) - Biological Process for MIR601 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR601 Gene

Transcripts for MIR601 Gene

fRNAdb Secondary structures for MIR601 Gene

  • hsa-mir-601_MI0003614_Homo_sapiens_miR-601_stem-loop_hairpin

mRNA/cDNA for MIR601 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR601 Gene

No ASD Table

Relevant External Links for MIR601 Gene

GeneLoc Exon Structure for
MIR601
ECgene alternative splicing isoforms for
MIR601

Expression for MIR601 Gene

mRNA expression in normal human tissues for MIR601 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR601 Gene:

MIR601
genes like me logo Genes that share expression patterns with MIR601: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR601 Gene

Orthologs for MIR601 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR601 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-601 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR601 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR601 Gene

ENSEMBL:
Gene Tree for MIR601 (if available)
TreeFam:
Gene Tree for MIR601 (if available)

Paralogs for MIR601 Gene

No data available for Paralogs for MIR601 Gene

Variants for MIR601 Gene

Sequence variations from dbSNP and Humsavar for MIR601 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10739631 -- 123,402,283(+) AATTC(C/T)GGAAC intron-variant, downstream-variant-500B
rs10986007 -- 123,402,244(+) CGTGC(A/G)CACAC intron-variant, downstream-variant-500B
rs10986008 -- 123,403,754(+) GATAG(C/T)TCCAT intron-variant, upstream-variant-2KB
rs10986009 -- 123,404,417(+) GAAAG(A/T)CTATC intron-variant, upstream-variant-2KB
rs111458914 -- 123,403,286(+) CACCC(A/G/T)CTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR601 Gene

Variant ID Type Subtype PubMed ID
nsv518647 CNV loss 19592680
nsv615285 CNV loss 21841781

Relevant External Links for MIR601 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR601

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR601 Gene

Disorders for MIR601 Gene

Relevant External Links for MIR601

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR601

No disorders were found for MIR601 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR601 Gene

Publications for MIR601 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer. (PMID: 22970209) Wang Q. … Du X. (PLoS ONE 2012) 3 64
  3. Profiling of molecular pathways regulated by microRNA 601. (PMID: 19889580) Ohdaira H. … Yoshida K. (Comput Biol Chem 2009) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR601 Gene

Sources for MIR601 Gene

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