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Aliases for MIR601 Gene

Subcategory (RNA class) for MIR601 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR601 Gene

  • MicroRNA 601 2 3 5
  • Hsa-Mir-601 3
  • MIRN601 3

External Ids for MIR601 Gene

Previous HGNC Symbols for MIR601 Gene

  • MIRN601

Previous GeneCards Identifiers for MIR601 Gene

  • GC09M125205
  • GC09M126164

Summaries for MIR601 Gene

Entrez Gene Summary for MIR601 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR601 Gene

MIR601 (MicroRNA 601) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR601 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR601

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR601 Gene

Genomics for MIR601 Gene

Regulatory Elements for MIR601 Gene

Enhancers for MIR601 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G123355 1.5 Ensembl ENCODE dbSUPER 12.4 +44.1 44083 6.2 HDGF ATF1 MLX CREB3L1 ZFP64 ARID4B ZNF48 TCF12 GLIS2 CBX5 STRBP MIR601 DENND1A MIR600HG MIR600 CRB2 GC09P123401
GH09G123364 1.2 FANTOM5 ENCODE dbSUPER 12.4 +38.1 38065 0.7 TFAP4 MAZ NFIB BHLHE40 ZNF398 ZBTB7A HIC1 ZFHX2 JUND ZNF157 MIR601 DENND1A MIR600 MIR600HG STRBP CRB2 GC09P123401
GH09G123375 1 ENCODE dbSUPER 12.6 +26.5 26491 1.3 KLF1 SAP130 AGO1 KLF17 FEZF1 ZIC2 SCRT2 PATZ1 ZNF600 DEK CRB2 MIR601 DENND1A STRBP GC09P123401
GH09G123377 1 ENCODE dbSUPER 12.6 +25.1 25127 0.2 PKNOX1 ESRRA KLF1 KLF17 ZFHX2 CTBP1 GATA3 POLR2A FOS MAZ MIR601 DENND1A CRB2 GC09P123401
GH09G123379 0.9 dbSUPER 12.7 +20.7 20657 5.9 FOXA2 ARID4B DNMT3B ZNF48 RAD21 YY1 FOS IKZF2 EGR2 ZNF263 CRB2 MIR601 DENND1A MIR600HG MIR600 STRBP GC09P123401
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR601 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR601 Gene

Chromosome:
9
Start:
123,402,525 bp from pter
End:
123,402,603 bp from pter
Size:
79 bases
Orientation:
Minus strand

Genomic View for MIR601 Gene

Genes around MIR601 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR601 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR601 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR601 Gene

ORGUL Member Location for MIR601 Gene

ORGUL Member Location for MIR601 gene

Proteins for MIR601 Gene

Post-translational modifications for MIR601 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR601 Gene

Domains & Families for MIR601 Gene

Gene Families for MIR601 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR601: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR601 Gene

Function for MIR601 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR601 Gene

Localization for MIR601 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR601 Gene

Pathways & Interactions for MIR601 Gene

SuperPathways for MIR601 Gene

No Data Available

Interacting Proteins for MIR601 Gene

Gene Ontology (GO) - Biological Process for MIR601 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR601 Gene

Drugs & Compounds for MIR601 Gene

No Compound Related Data Available

Transcripts for MIR601 Gene

fRNAdb Secondary structures for MIR601 Gene

  • hsa-mir-601_MI0003614_Homo_sapiens_miR-601_stem-loop_hairpin

mRNA/cDNA for MIR601 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR601 Gene

No ASD Table

Relevant External Links for MIR601 Gene

GeneLoc Exon Structure for
MIR601
ECgene alternative splicing isoforms for
MIR601

Expression for MIR601 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR601 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR601 Gene:

MIR601
genes like me logo Genes that share expression patterns with MIR601: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR601 Gene

Orthologs for MIR601 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR601 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-601 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR601 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR601 Gene

ENSEMBL:
Gene Tree for MIR601 (if available)
TreeFam:
Gene Tree for MIR601 (if available)

Paralogs for MIR601 Gene

No data available for Paralogs for MIR601 Gene

Variants for MIR601 Gene

Sequence variations from dbSNP and Humsavar for MIR601 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000040471 -- 123,402,956(+) CAGGT(A/G)GGCAA intron-variant, upstream-variant-2KB
rs1000421795 -- 123,404,392(+) AGGGA(C/T)GGGTT intron-variant, upstream-variant-2KB
rs1003821932 -- 123,402,605(+) TGCAC(G/T)TTTTC intron-variant, upstream-variant-2KB
rs1004689981 -- 123,403,581(+) CCCCC(C/G)AAAAA intron-variant, upstream-variant-2KB
rs1004824449 -- 123,403,814(+) TAGGA(C/G)CCGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR601 Gene

Variant ID Type Subtype PubMed ID
nsv518647 CNV loss 19592680
nsv615285 CNV loss 21841781

Relevant External Links for MIR601 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR601

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR601 Gene

Disorders for MIR601 Gene

Relevant External Links for MIR601

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR601

No disorders were found for MIR601 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR601 Gene

Publications for MIR601 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR-601 is a prognostic marker and suppresses cell growth and invasion by targeting PTP4A1 in breast cancer. (PMID: 27044835) Hu J.Y. … Chen J.S. (Biomed. Pharmacother. 2016) 3 64
  3. Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer. (PMID: 22970209) Wang Q. … Du X. (PLoS ONE 2012) 3 64
  4. Profiling of molecular pathways regulated by microRNA 601. (PMID: 19889580) Ohdaira H. … Yoshida K. (Comput Biol Chem 2009) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR601 Gene

Sources for MIR601 Gene

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