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Aliases for MIR599 Gene

Subcategory (RNA class) for MIR599 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR599 Gene

  • MicroRNA 599 2 3 5
  • Hsa-Mir-599 3
  • MIRN599 3

External Ids for MIR599 Gene

Previous HGNC Symbols for MIR599 Gene

  • MIRN599

Previous GeneCards Identifiers for MIR599 Gene

  • GC08M100621
  • GC08M100548

Summaries for MIR599 Gene

Entrez Gene Summary for MIR599 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR599 Gene

MIR599 (MicroRNA 599) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR599 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR599

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR599 Gene

Genomics for MIR599 Gene

Regulatory Elements for MIR599 Gene

Enhancers for MIR599 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G099636 0.7 ENCODE 10.1 -97.6 -97648 0.2 OVOL3 FEZF1 ZIC2 ZNF843 OSR2 PRDM6 GATA3 TCF7 CREB1 ZNF24 MIR599 MIR875 RN7SL350P LETM1P3
GH08G099634 0.6 ENCODE 10.1 -97.4 -97428 0.2 OSR2 GATA3 PRDM6 TCF7 ZNF24 ZNF843 TCF7L2 ZNF18 MIR875 MIR599 RN7SL350P LETM1P3
GH08G099577 0.5 ENCODE 11 -41.2 -41150 1.3 SP1 ZBTB33 ZNF623 MIR599 MIR875 GC08M099603
GH08G099605 0.5 Ensembl ENCODE 10.6 -69.9 -69917 1.7 MIR599 MIR875 GC08M099603
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR599 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR599 Gene

Chromosome:
8
Start:
99,536,636 bp from pter
End:
99,536,730 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR599 Gene

Genes around MIR599 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR599 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR599 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR599 Gene

ORGUL Member Location for MIR599 Gene

ORGUL Member Location for MIR599 gene

Proteins for MIR599 Gene

Post-translational modifications for MIR599 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR599 Gene

Domains & Families for MIR599 Gene

Gene Families for MIR599 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR599: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR599 Gene

Function for MIR599 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR599 Gene

Localization for MIR599 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR599 Gene

Pathways & Interactions for MIR599 Gene

SuperPathways for MIR599 Gene

No Data Available

Interacting Proteins for MIR599 Gene

Gene Ontology (GO) - Biological Process for MIR599 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR599 Gene

Drugs & Compounds for MIR599 Gene

No Compound Related Data Available

Transcripts for MIR599 Gene

fRNAdb Secondary structures for MIR599 Gene

  • hsa-mir-599_MI0003611_Homo_sapiens_miR-599_stem-loop_hairpin

mRNA/cDNA for MIR599 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR599 Gene

No ASD Table

Relevant External Links for MIR599 Gene

GeneLoc Exon Structure for
MIR599
ECgene alternative splicing isoforms for
MIR599

Expression for MIR599 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR599 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR599 Gene:

MIR599
genes like me logo Genes that share expression patterns with MIR599: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR599 Gene

Orthologs for MIR599 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR599 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-599 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-599 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-599 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-599 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir599 35
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 70 (a)
OneToOne
Species where no ortholog for MIR599 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR599 Gene

ENSEMBL:
Gene Tree for MIR599 (if available)
TreeFam:
Gene Tree for MIR599 (if available)

Paralogs for MIR599 Gene

No data available for Paralogs for MIR599 Gene

Variants for MIR599 Gene

Sequence variations from dbSNP and Humsavar for MIR599 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000222810 -- 99,538,584(+) CGCAT(A/G)TGAGT intron-variant, upstream-variant-2KB
rs1000509333 -- 99,536,543(+) TATGT(A/G)TGTGG intron-variant, downstream-variant-500B
rs1000558271 -- 99,536,812(+) GTGTT(A/T)CCAGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000972532 -- 99,537,253(+) TTAAA(A/G)TATAG intron-variant, upstream-variant-2KB
rs1001632963 -- 99,537,710(+) TAGAG(A/G)AAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR599 Gene

Variant ID Type Subtype PubMed ID
esv2759633 CNV loss 17122850
nsv1020614 CNV loss 25217958
nsv524617 CNV loss 19592680
nsv831408 CNV loss 17160897

Relevant External Links for MIR599 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR599

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR599 Gene

Disorders for MIR599 Gene

Relevant External Links for MIR599

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR599

No disorders were found for MIR599 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR599 Gene

Publications for MIR599 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR-599 Inhibits Vascular Smooth Muscle Cells Proliferation and Migration by Targeting TGFB2. (PMID: 26551255) Xie B. … Jiang S. (PLoS ONE 2015) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR599 Gene

Sources for MIR599 Gene

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