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Aliases for MIR598 Gene

Subcategory (RNA class) for MIR598 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR598 Gene

  • MicroRNA 598 2 3 5
  • Hsa-Mir-598 3
  • Mir-598 3
  • MIRN598 3

External Ids for MIR598 Gene

Previous HGNC Symbols for MIR598 Gene

  • MIRN598

Previous GeneCards Identifiers for MIR598 Gene

  • GC08M010931
  • GC08M010892

Summaries for MIR598 Gene

Entrez Gene Summary for MIR598 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR598 Gene

MIR598 (MicroRNA 598) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR598 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR598

Additional gene information for MIR598 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR598 Gene

Genomics for MIR598 Gene

GeneHancer (GH) Regulatory Elements for MIR598 Gene

Promoters and enhancers for MIR598 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I010990 Enhancer 1 ENCODE 12 +45.0 44956 0.2 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF766 ZNF143 DEK MIR598 LINC00529 GC08P010967 PIR55470 XKR6
GH08I011013 Enhancer 1.5 FANTOM5 Ensembl ENCODE 0.4 +19.7 19734 3.2 PKNOX1 ARNT SIN3A ZNF2 ZNF213 ZNF207 ZNF143 KLF13 SP3 REST MTMR9 ENSG00000269918 ENSG00000255310 XKR6 MIR598 PIR55470 GC08P010967
GH08I011063 Enhancer 1 Ensembl ENCODE 0.3 -30.4 -30361 4.2 PKNOX1 KLF17 ZNF76 ZNF2 RFX5 ZNF335 ZNF366 ZSCAN5C FOS CREM LOC101929269 ENSG00000255310 ENSG00000269954 ENSG00000254936 ENSG00000269918 MIR598 XKR6
GH08I011059 Enhancer 0.9 Ensembl ENCODE 0.3 -24.2 -24199 1 MAZ NRF1 ZBTB8A ATF2 E2F1 ZNF335 ZFHX2 GLIS2 POLR2A GLIS1 ENSG00000269918 ENSG00000255310 ENSG00000254936 LOC101929269 MIR598 XKR6
GH08I011047 Enhancer 0.5 ENCODE 0.4 -12.8 -12819 0.6 SCRT1 CTCF SCRT2 ZIC2 ZBTB20 ENSG00000255310 LOC105379241 MIR598 LOC101929269 XKR6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR598 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR598 Gene

Genomic Locations for MIR598 Gene
chr8:11,035,206-11,035,302
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr8:10,892,716-10,892,812
(GRCh37/hg19)

Genomic View for MIR598 Gene

Genes around MIR598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR598 Gene

ORGUL Member Location for MIR598 Gene

ORGUL Member Location for MIR598 gene

Proteins for MIR598 Gene

Post-translational modifications for MIR598 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR598 Gene

Domains & Families for MIR598 Gene

Gene Families for MIR598 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR598: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR598 Gene

Function for MIR598 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR598 Gene

Localization for MIR598 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR598 Gene

Pathways & Interactions for MIR598 Gene

genes like me logo Genes that share pathways with MIR598: view

Pathways by source for MIR598 Gene

1 BioSystems pathway for MIR598 Gene

Interacting Proteins for MIR598 Gene

Gene Ontology (GO) - Biological Process for MIR598 Gene

None

No data available for SIGNOR curated interactions for MIR598 Gene

Drugs & Compounds for MIR598 Gene

No Compound Related Data Available

Transcripts for MIR598 Gene

fRNAdb Secondary structures for MIR598 Gene

  • FR035177
  • hsa-miR-598-3p_MIMAT0003266_Homo_sapiens_miR-598-3p_mature

mRNA/cDNA for MIR598 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR598 Gene

No ASD Table

Relevant External Links for MIR598 Gene

GeneLoc Exon Structure for
MIR598
ECgene alternative splicing isoforms for
MIR598

Expression for MIR598 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR598 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR598 Gene:

MIR598
genes like me logo Genes that share expression patterns with MIR598: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR598 Gene

Orthologs for MIR598 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-598 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir598 34
  • 93 (a)
OneToOne
Species where no ortholog for MIR598 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR598 Gene

ENSEMBL:
Gene Tree for MIR598 (if available)
TreeFam:
Gene Tree for MIR598 (if available)

Paralogs for MIR598 Gene

No data available for Paralogs for MIR598 Gene

Variants for MIR598 Gene

Sequence variations from dbSNP and Humsavar for MIR598 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000045759 -- 11,036,250(-) G/C upstream_transcript_variant
rs1000482653 -- 11,036,032(-) C/G upstream_transcript_variant
rs1002242555 -- 11,036,584(-) A/T upstream_transcript_variant
rs1003662613 -- 11,035,824(-) G/A upstream_transcript_variant
rs1003896926 -- 11,036,507(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR598 Gene

Variant ID Type Subtype PubMed ID
nsv1022434 CNV gain 25217958

Additional Variant Information for MIR598 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR598

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR598 Gene

Disorders for MIR598 Gene

Additional Disease Information for MIR598

No disorders were found for MIR598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR598 Gene

Publications for MIR598 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MiR-598: A tumor suppressor with biomarker significance in osteosarcoma. (PMID: 28882648) Liu K … Yuan Q (Life sciences 2017) 3 58
  3. Novel Biomarkers for Non-functioning Invasive Pituitary Adenomas were Identified by Using Analysis of microRNAs Expression Profile. (PMID: 28315020) Wu S … Zhang X (Biochemical genetics 2017) 3 58
  4. miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT. (PMID: 28161537) Chen J … Ma L (Experimental cell research 2017) 3 58
  5. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3 58

Products for MIR598 Gene

Sources for MIR598 Gene

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