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Aliases for MIR598 Gene

Subcategory (RNA class) for MIR598 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR598 Gene

  • MicroRNA 598 2 3 5
  • Hsa-Mir-598 3
  • Mir-598 3
  • MIRN598 3

External Ids for MIR598 Gene

Previous HGNC Symbols for MIR598 Gene

  • MIRN598

Previous GeneCards Identifiers for MIR598 Gene

  • GC08M010931
  • GC08M010892

Summaries for MIR598 Gene

Entrez Gene Summary for MIR598 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR598 Gene

MIR598 (MicroRNA 598) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR598 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR598

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR598 Gene

Genomics for MIR598 Gene

Regulatory Elements for MIR598 Gene

Enhancers for MIR598 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F010990 1 ENCODE 11.9 +45.0 44957 0.2 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ELK1 ZNF143 DEK MIR598 LINC00529 GC08P010967 PIR55470
GH08F011072 0.7 Ensembl 10.8 -36.9 -36900 0.4 KLF1 PKNOX1 SP3 SP2 ZIC2 ZFHX2 PATZ1 GLIS1 ZNF341 KLF9 ENSG00000269918 MIR598 LINC00529 FAM167A LOC101929269
GH08F011013 1.6 FANTOM5 Ensembl ENCODE 0.3 +19.7 19734 3.2 ATF1 PKNOX1 SIN3A ZNF2 ETS1 GLIS2 ELK1 GATA2 ZNF143 ZNF207 ENSG00000269918 ENSG00000255310 MTMR9 XKR6 MIR598 GC08P010967 PIR55470
GH08F011063 1.1 Ensembl ENCODE 0.3 -30.4 -30362 4.2 ATF1 PKNOX1 ZNF133 ZNF76 KLF17 ZNF2 RFX5 CBX5 ZNF366 SCRT2 ENSG00000255310 ENSG00000269954 ENSG00000254936 ENSG00000269918 LOC101929269 MIR598
GH08F011059 0.9 Ensembl ENCODE 0.3 -24.2 -24199 1.0 MAZ NRF1 ZBTB8A E2F1 ZFHX2 GLIS2 SMARCA4 POLR2A ZNF341 GLIS1 ENSG00000269918 ENSG00000255310 ENSG00000254936 LOC101929269 MIR598
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR598 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR598 Gene

Chromosome:
8
Start:
11,035,206 bp from pter
End:
11,035,302 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR598 Gene

Genes around MIR598 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR598 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR598 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR598 Gene

ORGUL Member Location for MIR598 Gene

ORGUL Member Location for MIR598 gene

Proteins for MIR598 Gene

Post-translational modifications for MIR598 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR598 Gene

Domains & Families for MIR598 Gene

Gene Families for MIR598 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR598: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR598 Gene

Function for MIR598 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR598 Gene

Localization for MIR598 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR598 Gene

Pathways & Interactions for MIR598 Gene

genes like me logo Genes that share pathways with MIR598: view

Pathways by source for MIR598 Gene

1 BioSystems pathway for MIR598 Gene

Interacting Proteins for MIR598 Gene

Gene Ontology (GO) - Biological Process for MIR598 Gene

None

No data available for SIGNOR curated interactions for MIR598 Gene

Transcripts for MIR598 Gene

fRNAdb Secondary structures for MIR598 Gene

  • FR035177
  • hsa-miR-598-3p_MIMAT0003266_Homo_sapiens_miR-598-3p_mature

mRNA/cDNA for MIR598 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR598 Gene

No ASD Table

Relevant External Links for MIR598 Gene

GeneLoc Exon Structure for
MIR598
ECgene alternative splicing isoforms for
MIR598

Expression for MIR598 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR598 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR598 Gene:

MIR598
genes like me logo Genes that share expression patterns with MIR598: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR598 Gene

Orthologs for MIR598 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR598 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-598 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir598 35
  • 93 (a)
OneToOne
Species where no ortholog for MIR598 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR598 Gene

ENSEMBL:
Gene Tree for MIR598 (if available)
TreeFam:
Gene Tree for MIR598 (if available)

Paralogs for MIR598 Gene

No data available for Paralogs for MIR598 Gene

Variants for MIR598 Gene

Sequence variations from dbSNP and Humsavar for MIR598 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10101140 -- 11,036,400(+) CCCCA(A/G)AGATA intron-variant, upstream-variant-2KB
rs112092732 -- 11,035,563(+) TGCAG(C/G)TGAAC intron-variant, upstream-variant-2KB
rs113242169 -- 11,035,024(+) CGTAC(A/G)CATTT intron-variant, downstream-variant-500B
rs113249517 -- 11,034,856(+) CATAC(C/T)GGCCA intron-variant, downstream-variant-500B
rs113605113 -- 11,034,898(+) GCTGG(C/G)CTTCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR598 Gene

Variant ID Type Subtype PubMed ID
nsv1022434 CNV gain 25217958

Relevant External Links for MIR598 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR598

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR598 Gene

Disorders for MIR598 Gene

Relevant External Links for MIR598

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR598

No disorders were found for MIR598 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR598 Gene

Publications for MIR598 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR598 Gene

Sources for MIR598 Gene

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