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Aliases for MIR596 Gene

Subcategory (RNA class) for MIR596 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR596 Gene

  • MicroRNA 596 2 3 5
  • Hsa-Mir-596 3
  • MIRN596 3

External Ids for MIR596 Gene

Previous HGNC Symbols for MIR596 Gene

  • MIRN596

Previous GeneCards Identifiers for MIR596 Gene

  • GC08P001754
  • GC08P001765

Summaries for MIR596 Gene

Entrez Gene Summary for MIR596 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR596 Gene

MIR596 (MicroRNA 596) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR596 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR596 Gene

Genomics for MIR596 Gene

GeneHancer (GH) Regulatory Elements for MIR596 Gene

Promoters and enhancers for MIR596 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I001816 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.3 343 2 CTCF EGR1 NRF1 ZIC2 GC08P001818 GC08P001819 MIR596 CLN8 ARHGEF10 GC08P001427
GH08I001817 Enhancer 0.5 Ensembl dbSUPER 550.8 -0.9 -930 0.2 ZBTB10 GC08P001818 GC08P001819 MIR596 ARHGEF10 LOC105377779 GC08P001427
GH08I001785 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -29.7 -29733 3.8 KLF1 JUN RFX5 HIC1 FOSL1 GLIS2 ZNF366 RCOR1 FOSL2 FOS ENSG00000253982 CLN8 MIR596 PIR39323 MIR3674 GC08P001427
GH08I001889 Enhancer 0.6 FANTOM5 dbSUPER 11.4 +72.6 72613 0.4 GLIS2 GLIS1 MIR596 GC08P001908 ARHGEF10 GC08P001427
GH08I001854 Enhancer 0.3 ENCODE 11.9 +38.5 38500 2.6 CEBPB MIR596 ARHGEF10 GC08P001908 GC08P001427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR596 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR596 Gene

Genomic Locations for MIR596 Gene
chr8:1,817,231-1,817,307
(GRCh38/hg38)
Size:
77 bases
Orientation:
Plus strand
chr8:1,765,397-1,765,473
(GRCh37/hg19)

Genomic View for MIR596 Gene

Genes around MIR596 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR596 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR596 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR596 Gene

Proteins for MIR596 Gene

Post-translational modifications for MIR596 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR596 Gene

Domains & Families for MIR596 Gene

Gene Families for MIR596 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR596: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR596 Gene

Function for MIR596 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR596 Gene

Localization for MIR596 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR596 Gene

Pathways & Interactions for MIR596 Gene

SuperPathways for MIR596 Gene

No Data Available

Interacting Proteins for MIR596 Gene

Gene Ontology (GO) - Biological Process for MIR596 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR596 Gene

Drugs & Compounds for MIR596 Gene

No Compound Related Data Available

Transcripts for MIR596 Gene

mRNA/cDNA for MIR596 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR596 Gene

No ASD Table

Relevant External Links for MIR596 Gene

GeneLoc Exon Structure for
MIR596
ECgene alternative splicing isoforms for
MIR596

Expression for MIR596 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR596 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR596 Gene:

MIR596
genes like me logo Genes that share expression patterns with MIR596: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR596 Gene

Orthologs for MIR596 Gene

Evolution for MIR596 Gene

ENSEMBL:
Gene Tree for MIR596 (if available)
TreeFam:
Gene Tree for MIR596 (if available)

No data available for Orthologs for MIR596 Gene

Paralogs for MIR596 Gene

No data available for Paralogs for MIR596 Gene

Variants for MIR596 Gene

Sequence variations from dbSNP and Humsavar for MIR596 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000146753 -- 1,816,835(+) C/A upstream_transcript_variant
rs1001303252 -- 1,816,241(+) G/C upstream_transcript_variant
rs1002216360 -- 1,815,505(+) A/C upstream_transcript_variant
rs1002920825 -- 1,815,306(+) G/A upstream_transcript_variant
rs1005501411 -- 1,815,364(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR596 Gene

Variant ID Type Subtype PubMed ID
dgv11822n54 CNV loss 21841781
dgv850n27 CNV loss 19166990
esv3576504 CNV gain 25503493
esv3615841 CNV loss 21293372
esv3615842 CNV gain 21293372
esv3891267 CNV gain 25118596
nsv1017597 CNV loss 25217958
nsv1024325 CNV gain 25217958
nsv1025591 CNV gain 25217958
nsv465277 CNV gain 19166990
nsv470167 CNV gain 18288195
nsv509244 CNV insertion 20534489
nsv609531 CNV gain 21841781
nsv609533 CNV gain 21841781
nsv824454 CNV gain 20364138

Additional Variant Information for MIR596 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR596

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR596 Gene

Disorders for MIR596 Gene

Additional Disease Information for MIR596

No disorders were found for MIR596 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR596 Gene

Publications for MIR596 Gene

  1. Exploration of Alternative Mechanism for MiR-596-mediated Down-regulation of LGALS3BP in Oral Squamous Cell Carcinoma. (PMID: 26502662) Li H (Kokubyo Gakkai zasshi. The Journal of the Stomatological Society, Japan 2015) 3 58
  2. Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer. (PMID: 23233740) Endo H … Kozaki K (Carcinogenesis 2013) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58

Products for MIR596 Gene

Sources for MIR596 Gene

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