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Aliases for MIR595 Gene

Subcategory (RNA class) for MIR595 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR595 Gene

  • MicroRNA 595 2 3
  • Hsa-Mir-595 3
  • MIRN595 3

External Ids for MIR595 Gene

Previous Symbols for MIR595 Gene

  • MIRN595

Summaries for MIR595 Gene

Entrez Gene Summary for MIR595 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR595 Gene

MIR595 (MicroRNA 595) is an RNA Gene, and belongs to the miRNA class.

fRNAdb sequence ontologies for MIR595 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR595

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR595 Gene

Genomics for MIR595 Gene

Genomic Location for MIR595 Gene

Start:
158,532,718 bp from pter
End:
158,532,813 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR595 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR595 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR595 Gene

ORGUL Member Location for MIR595 Gene

ORGUL Member Location for MIR595 gene

No data available for Regulatory Elements for MIR595 Gene

Proteins for MIR595 Gene

Post-translational modifications for MIR595 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR595 Gene

Domains for MIR595 Gene

Gene Families for MIR595 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR595: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR595 Gene

Function for MIR595 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR595 Gene

Localization for MIR595 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR595 Gene

Pathways for MIR595 Gene

SuperPathways for MIR595 Gene

No Data Available

Interacting Proteins for MIR595 Gene

Gene Ontology (GO) - Biological Process for MIR595 Gene

None

No data available for Pathways by source for MIR595 Gene

Transcripts for MIR595 Gene

fRNAdb Secondary structures for MIR595 Gene

  • hsa-mir-595_MI0003607_Homo_sapiens_miR-595_stem-loop_hairpin

mRNA/cDNA for MIR595 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR595 Gene

No ASD Table

Relevant External Links for MIR595 Gene

GeneLoc Exon Structure for
MIR595
ECgene alternative splicing isoforms for
MIR595

Expression for MIR595 Gene

mRNA expression in normal human tissues for MIR595 Gene

genes like me logo Genes that share expressions with MIR595: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR595 Gene

Orthologs for MIR595 Gene

Evolution for MIR595 Gene

ENSEMBL:
Gene Tree for MIR595 (if available)
TreeFam:
Gene Tree for MIR595 (if available)

No data available for Orthologs for MIR595 Gene

Paralogs for MIR595 Gene

No data available for Paralogs for MIR595 Gene

Variants for MIR595 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR595 Gene

Variant ID Type Subtype PubMed ID
nsv889636 CNV Gain 21882294
nsv889639 CNV Loss 21882294
dgv7578n71 CNV Gain 21882294
nsv889641 CNV Loss 21882294

Relevant External Links for MIR595 Gene

HapMap Linkage Disequilibrium report
MIR595

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR595 Gene

Disorders for MIR595 Gene

No disorders were found for MIR595 Gene.

No data available for UniProtKB/Swiss-Prot for MIR595 Gene

Publications for MIR595 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for MIR595 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR595
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR595
    • Block miRNA regulation of MIR595 using miScript Target Protectors

    Sources for MIR595 Gene

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