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Aliases for MIR592 Gene

Subcategory (RNA class) for MIR592 Gene


Quality Score for this RNA gene is


Aliases for MIR592 Gene

  • MicroRNA 592 2 3 5
  • Hsa-Mir-592 3
  • Mir-592 3
  • MIRN592 3

External Ids for MIR592 Gene

Previous HGNC Symbols for MIR592 Gene

  • MIRN592

Previous GeneCards Identifiers for MIR592 Gene

  • GC07M126486
  • GC07M126698

Summaries for MIR592 Gene

Entrez Gene Summary for MIR592 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR592 Gene

MIR592 (MicroRNA 592) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR592 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR592

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR592 Gene

Genomics for MIR592 Gene

Regulatory Elements for MIR592 Gene

Enhancers for MIR592 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G127018 0.5 FANTOM5 0.3 +39.9 39891 0.3 IKZF1 ZNF207 GRM8 ENSG00000230820 MIR592
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR592 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR592 Gene

127,058,088 bp from pter
127,058,184 bp from pter
97 bases
Minus strand

Genomic View for MIR592 Gene

Genes around MIR592 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR592 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR592 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR592 Gene

ORGUL Member Location for MIR592 Gene

ORGUL Member Location for MIR592 gene

Proteins for MIR592 Gene

Post-translational modifications for MIR592 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR592 Gene

Domains & Families for MIR592 Gene

Gene Families for MIR592 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR592: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR592 Gene

Function for MIR592 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR592 Gene

Localization for MIR592 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR592 Gene

Pathways & Interactions for MIR592 Gene

SuperPathways for MIR592 Gene

No Data Available

Interacting Proteins for MIR592 Gene

Gene Ontology (GO) - Biological Process for MIR592 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR592 Gene

Drugs & Compounds for MIR592 Gene

No Compound Related Data Available

Transcripts for MIR592 Gene

fRNAdb Secondary structures for MIR592 Gene

  • FR005308

mRNA/cDNA for MIR592 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR592 Gene

No ASD Table

Relevant External Links for MIR592 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR592 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR592 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR592 Gene:

genes like me logo Genes that share expression patterns with MIR592: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR592 Gene

Orthologs for MIR592 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR592 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-592 35
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-592 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-592 35
  • 96 (a)
(Mus musculus)
Mammalia Mir592 35
  • 96 (a)
Species where no ortholog for MIR592 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR592 Gene

Gene Tree for MIR592 (if available)
Gene Tree for MIR592 (if available)

Paralogs for MIR592 Gene

No data available for Paralogs for MIR592 Gene

Variants for MIR592 Gene

Sequence variations from dbSNP and Humsavar for MIR592 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1001504552 -- 127,059,535(+) TTTCA(C/T)CCTAT intron-variant, upstream-variant-2KB
rs1002299914 -- 127,059,285(+) TTTGT(A/T)GATGT intron-variant, upstream-variant-2KB
rs1002517148 -- 127,058,068(+) TTCTG(A/G)AATCA intron-variant, downstream-variant-500B
rs1004193820 -- 127,058,924(+) GACCT(C/T)TCTTT intron-variant, upstream-variant-2KB
rs1004269576 -- 127,058,431(+) CCTTG(A/C)CCCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR592 Gene

Variant ID Type Subtype PubMed ID
nsv831121 CNV gain 17160897

Relevant External Links for MIR592 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR592 Gene

Disorders for MIR592 Gene

Relevant External Links for MIR592

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR592 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR592 Gene

Publications for MIR592 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR-592 functions as a tumor suppressor in human non-small cell lung cancer by targeting SOX9. (PMID: 28004116) Li Z. … Ge L. (Oncol. Rep. 2017) 3 64
  3. MicroRNA-592 targets DEK oncogene and suppresses cell growth in the hepatocellular carcinoma cell line HepG2. (PMID: 26722432) Li X. … Su X. (Int J Clin Exp Pathol 2015) 3 64
  4. miRNA-592 is downregulated and may target LHCGR in polycystic ovary syndrome patients. (PMID: 26679164) Song J. … Li S.W. (Reprod Biol 2015) 3 64
  5. Up-regulation of miR-592 correlates with tumor progression and poor prognosis in patients with colorectal cancer. (PMID: 25661360) Liu M. … Ma Q. (Biomed. Pharmacother. 2015) 3 64

Products for MIR592 Gene

Sources for MIR592 Gene

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