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Aliases for MIR592 Gene

Subcategory (RNA class) for MIR592 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR592 Gene

  • MicroRNA 592 2 3
  • Hsa-Mir-592 3
  • MIRN592 3

External Ids for MIR592 Gene

Previous Symbols for MIR592 Gene

  • MIRN592

Summaries for MIR592 Gene

Entrez Gene Summary for MIR592 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR592 Gene

MIR592 (MicroRNA 592) is an RNA Gene, and belongs to the miRNA class.

fRNAdb sequence ontologies for MIR592 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR592

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR592 Gene

Genomics for MIR592 Gene

Genomic Location for MIR592 Gene

Start:
127,058,079 bp from pter
End:
127,058,187 bp from pter
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR592 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR592 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR592 Gene

ORGUL Member Location for MIR592 Gene

ORGUL Member Location for MIR592 gene

No data available for Regulatory Elements for MIR592 Gene

Proteins for MIR592 Gene

Post-translational modifications for MIR592 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR592 Gene

Domains for MIR592 Gene

Gene Families for MIR592 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR592: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR592 Gene

Function for MIR592 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR592 Gene

Localization for MIR592 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR592 Gene

Pathways for MIR592 Gene

SuperPathways for MIR592 Gene

No Data Available

Interacting Proteins for MIR592 Gene

Gene Ontology (GO) - Biological Process for MIR592 Gene

None

No data available for Pathways by source for MIR592 Gene

Transcripts for MIR592 Gene

fRNAdb Secondary structures for MIR592 Gene

  • FR005308

mRNA/cDNA for MIR592 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR592 Gene

No ASD Table

Relevant External Links for MIR592 Gene

GeneLoc Exon Structure for
MIR592
ECgene alternative splicing isoforms for
MIR592

Expression for MIR592 Gene

mRNA expression in normal human tissues for MIR592 Gene

genes like me logo Genes that share expressions with MIR592: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR592 Gene

Orthologs for MIR592 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR592 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-592 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-592 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-592 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir592 36
  • 96 (a)
OneToOne
Species with no ortholog for MIR592:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR592 Gene

ENSEMBL:
Gene Tree for MIR592 (if available)
TreeFam:
Gene Tree for MIR592 (if available)

Paralogs for MIR592 Gene

No data available for Paralogs for MIR592 Gene

Variants for MIR592 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR592 Gene

Variant ID Type Subtype PubMed ID
nsv831121 CNV Gain 17160897

Relevant External Links for MIR592 Gene

HapMap Linkage Disequilibrium report
MIR592

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR592 Gene

Disorders for MIR592 Gene

No disorders were found for MIR592 Gene.

No data available for UniProtKB/Swiss-Prot for MIR592 Gene

Publications for MIR592 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. miR-592 and miR-552 can distinguish between primary lung adenocarcinoma and colorectal cancer metastases in the lung. (PMID: 24778034) Kim J. … Lee G.K. (Anticancer Res. 2014) 3

Products for MIR592 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR592
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR592
    • Block miRNA regulation of MIR592 using miScript Target Protectors

    Sources for MIR592 Gene

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