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Aliases for MIR591 Gene

Subcategory (RNA class) for MIR591 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR591 Gene

  • MicroRNA 591 2 3 5
  • Hsa-Mir-591 3
  • MIRN591 3

External Ids for MIR591 Gene

Previous HGNC Symbols for MIR591 Gene

  • MIRN591

Previous GeneCards Identifiers for MIR591 Gene

  • GC07M095687
  • GC07M095848

Summaries for MIR591 Gene

Entrez Gene Summary for MIR591 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR591 Gene

MIR591 (MicroRNA 591) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR591 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR591

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR591 Gene

Genomics for MIR591 Gene

Regulatory Elements for MIR591 Gene

Enhancers for MIR591 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F096075 1.5 VISTA Ensembl ENCODE 9.7 +143.8 143755 1.2 CTCF ZNF76 ZNF2 RAD21 PATZ1 SMC3 ZSCAN29 TCF7L2 ZBTB20 ZNF263 DLX5 MIR591 GC07M096068 ENSG00000279067
GH07F096284 1.4 FANTOM5 Ensembl ENCODE 10.1 -66.4 -66443 3.2 BMI1 RAD21 RARA ETV6 CREM DEK ZNF654 JUNB REST KAT8 SLC25A13 MIR591 GC07P096284 ENSG00000275834
GH07F096245 1 VISTA 10.5 -27.4 -27407 3.3 SOX13 CEBPG ZNF644 RAD21 YY1 ZNF664 HNF4G HOMEZ GATAD2A ZNF680 SLC25A13 MIR591 RPL21P74
GH07F096242 0.6 Ensembl 10.5 -22.7 -22745 0.2 OSR2 HMBOX1 FEZF1 ZNF843 SPI1 SLC25A13 MIR591 RPL21P74
GH07F096188 0.5 Ensembl 10.7 +30.8 30756 0.4 NFIA HLF RAD21 YY1 MIR591 SLC25A13 GC07P096218 CYCSP18
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR591 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR591 Gene

Chromosome:
7
Start:
96,219,662 bp from pter
End:
96,219,756 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR591 Gene

Genes around MIR591 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR591 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR591 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR591 Gene

ORGUL Member Location for MIR591 Gene

ORGUL Member Location for MIR591 gene

Proteins for MIR591 Gene

Post-translational modifications for MIR591 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR591 Gene

Domains & Families for MIR591 Gene

Gene Families for MIR591 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR591: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR591 Gene

Function for MIR591 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR591 Gene

Localization for MIR591 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR591 Gene

Pathways & Interactions for MIR591 Gene

SuperPathways for MIR591 Gene

No Data Available

Interacting Proteins for MIR591 Gene

Gene Ontology (GO) - Biological Process for MIR591 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR591 Gene

Transcripts for MIR591 Gene

fRNAdb Secondary structures for MIR591 Gene

  • hsa-miR-591_MIMAT0003259_Homo_sapiens_miR-591_mature

mRNA/cDNA for MIR591 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR591 Gene

No ASD Table

Relevant External Links for MIR591 Gene

GeneLoc Exon Structure for
MIR591
ECgene alternative splicing isoforms for
MIR591

Expression for MIR591 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR591 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR591 Gene:

MIR591
genes like me logo Genes that share expression patterns with MIR591: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR591 Gene

Orthologs for MIR591 Gene

Evolution for MIR591 Gene

ENSEMBL:
Gene Tree for MIR591 (if available)
TreeFam:
Gene Tree for MIR591 (if available)

No data available for Orthologs for MIR591 Gene

Paralogs for MIR591 Gene

No data available for Paralogs for MIR591 Gene

Variants for MIR591 Gene

Sequence variations from dbSNP and Humsavar for MIR591 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111488375 -- 96,219,779(+) ATCTG(A/G)CAGAT intron-variant, upstream-variant-2KB
rs112001974 -- 96,219,545(+) TTTCC(C/T)CATCC intron-variant, downstream-variant-500B
rs112056037 -- 96,220,798(+) ACACA(A/C)ACACA intron-variant, upstream-variant-2KB
rs114928689 -- 96,221,195(+) GGAAC(A/G)GTTTC intron-variant, upstream-variant-2KB
rs11772017 -- 96,221,549(+) TCATT(G/T)TCGAA intron-variant, upstream-variant-2KB

Relevant External Links for MIR591 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR591

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR591 Gene

Disorders for MIR591 Gene

Relevant External Links for MIR591

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR591

No disorders were found for MIR591 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR591 Gene

Publications for MIR591 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer. (PMID: 23807165) Huh J.H. … An H.J. (Br. J. Cancer 2013) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR591 Gene

Sources for MIR591 Gene

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