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Aliases for MIR590 Gene

Subcategory (RNA class) for MIR590 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR590 Gene

  • MicroRNA 590 2 3 5
  • Hsa-Mir-590 3
  • Mir-590 3
  • MIRN590 3

External Ids for MIR590 Gene

ORGUL Members for MIR590 Gene

Previous HGNC Symbols for MIR590 Gene

  • MIRN590

Previous GeneCards Identifiers for MIR590 Gene

  • GC07P073244
  • GC07P073605

Summaries for MIR590 Gene

Entrez Gene Summary for MIR590 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR590 Gene

MIR590 (MicroRNA 590) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR590 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR590 Gene

Genomics for MIR590 Gene

Regulatory Elements for MIR590 Gene

Enhancers for MIR590 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H074635 1.8 FANTOM5 Ensembl ENCODE dbSUPER 43.3 +444.8 444838 2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FOS ZNF202 REST PPARG ZNF623 PMS2P3 STAG3L1 NSUN5P1 MIR590 SPDYE5 METTL27 GTF2IRD2 GTF2IRD2B LOC101926943 BUD23
GH07H073890 1.5 FANTOM5 Ensembl ENCODE dbSUPER 47.8 -300.8 -300797 0.8 ZBTB21 ZNF140 ZNF697 ZNF664 ZNF791 ZNF354C RBAK ZNF433 ZNF202 ZNF680 NSUN5P2 STAG3L3 BAZ1B GTF2IRD2 METTL27 POM121B MIR590 GTF2IRD2P1 LOC101926943 TBL2
GH07H073715 1.7 FANTOM5 ENCODE dbSUPER 28.7 -473.7 -473665 4.9 FOXA2 ZFP64 ARID4B SIN3A FEZF1 ZNF766 ZNF143 ZNF207 FOS SP3 POM121 POM121B NSUN5P2 MIR590 STAG3L3 NSUN5 TBL2 PMS2P7 RFC2 FKBP6
GH07H073736 2 FANTOM5 Ensembl ENCODE dbSUPER 20.8 -450.5 -450474 7.8 HDGF FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 METTL27 STAG3L3 POM121B ABHD11-AS1 POM121 NSUN5P2 MIR590 FKBP6 BUD23 SPDYE7P
GH07H074278 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.6 +88.9 88865 3.3 HDGF PKNOX1 ATF1 ARID4B SIN3A BRCA1 ZNF121 ZNF548 ATF7 FOS MIR590 POM121B RFC2 GTF2IRD2B BAZ1B GTF2IRD2P1 GTF2IRD2 LAT2 DNAJC30 TRIM50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR590 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR590 Gene

Genomic Locations for MIR590 Gene
chr7:74,191,198-74,191,294
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr7:73,605,528-73,605,624
(GRCh37/hg19)

Genomic View for MIR590 Gene

Genes around MIR590 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR590 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR590 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR590 Gene

Proteins for MIR590 Gene

Post-translational modifications for MIR590 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR590 Gene

Domains & Families for MIR590 Gene

Gene Families for MIR590 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR590: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR590 Gene

Function for MIR590 Gene

Gene Ontology (GO) - Molecular Function for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19398468
genes like me logo Genes that share ontologies with MIR590: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR590 Gene

Localization for MIR590 Gene

Gene Ontology (GO) - Cellular Components for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR590: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR590 Gene

Pathways & Interactions for MIR590 Gene

SuperPathways for MIR590 Gene

No Data Available

Interacting Proteins for MIR590 Gene

Gene Ontology (GO) - Biological Process for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 24288179
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 26459119
GO:0030335 positive regulation of cell migration IDA 24288179
GO:0035195 gene silencing by miRNA IDA 23598417
GO:0035278 miRNA mediated inhibition of translation IDA 19398468
genes like me logo Genes that share ontologies with MIR590: view

No data available for Pathways by source and SIGNOR curated interactions for MIR590 Gene

Drugs & Compounds for MIR590 Gene

No Compound Related Data Available

Transcripts for MIR590 Gene

mRNA/cDNA for MIR590 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR590 Gene

No ASD Table

Relevant External Links for MIR590 Gene

GeneLoc Exon Structure for
MIR590
ECgene alternative splicing isoforms for
MIR590

Expression for MIR590 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR590 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR590 Gene:

MIR590
genes like me logo Genes that share expression patterns with MIR590: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR590 Gene

Orthologs for MIR590 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR590 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-590 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-590 34
  • 69 (a)
OneToOne
Species where no ortholog for MIR590 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR590 Gene

ENSEMBL:
Gene Tree for MIR590 (if available)
TreeFam:
Gene Tree for MIR590 (if available)

Paralogs for MIR590 Gene

No data available for Paralogs for MIR590 Gene

Variants for MIR590 Gene

Sequence variations from dbSNP and Humsavar for MIR590 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002641739 -- 74,190,772(+) TCGCC(A/G)TTCTC intron-variant, upstream-variant-2KB
rs1003102510 -- 74,190,526(+) AGCCT(A/G)CAGCT intron-variant, upstream-variant-2KB
rs1005645334 -- 74,191,389(+) ACTAA(C/T)GTCTT intron-variant, downstream-variant-500B
rs1005930864 -- 74,190,511(+) GTGGT(C/G)ACCTT intron-variant, upstream-variant-2KB
rs1008393211 -- 74,190,138(+) GATTT(A/C)ATTGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR590 Gene

Variant ID Type Subtype PubMed ID
nsv831030 CNV gain 17160897
nsv607480 CNV gain 21841781
nsv464563 CNV gain 19166990
esv3613698 CNV loss 21293372

Relevant External Links for MIR590 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR590

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR590 Gene

Disorders for MIR590 Gene

Relevant External Links for MIR590

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR590

No disorders were found for MIR590 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR590 Gene

Publications for MIR590 Gene

  1. Suppressing the molecular signaling pathways involved in inflammation and cancer in breast cancer cell lines MDA-MB-231 and MCF-7 by miR-590. (PMID: 28443471) Sheikholeslami A … Arefian E (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  2. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. (PMID: 28433598) Ou C … Ma J (Cancer letters 2017) 3 60
  3. MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1. (PMID: 28349829) Ge X … Gong L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  4. MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells. (PMID: 28345464) Chen H … Li H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  5. MicroRNA-590-5p Stabilizes Runx2 by Targeting Smad7 During Osteoblast Differentiation. (PMID: 27192628) Vishal M … Selvamurugan N (Journal of cellular physiology 2017) 3 60

Products for MIR590 Gene

Sources for MIR590 Gene

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