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Aliases for MIR590 Gene

Subcategory (RNA class) for MIR590 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR590 Gene

  • MicroRNA 590 2 3 5
  • Hsa-Mir-590 3
  • Mir-590 3
  • MIRN590 3

External Ids for MIR590 Gene

ORGUL Members for MIR590 Gene

Previous HGNC Symbols for MIR590 Gene

  • MIRN590

Previous GeneCards Identifiers for MIR590 Gene

  • GC07P073244
  • GC07P073605

Summaries for MIR590 Gene

Entrez Gene Summary for MIR590 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR590 Gene

MIR590 (MicroRNA 590) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR590 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR590 Gene

Genomics for MIR590 Gene

GeneHancer (GH) Regulatory Elements for MIR590 Gene

Promoters and enhancers for MIR590 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I074635 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 43.3 +444.8 444838 2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A ZNF48 ETS1 FOS ZNF202 REST PMS2P3 STAG3L1 NSUN5P1 MIR590 SPDYE5 METTL27 GTF2IRD2 GTF2IRD2B LOC101926943 BUD23
GH07I073890 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 47.8 -300.8 -300797 0.8 ZBTB21 ZNF140 ZNF697 ZNF664 ZNF791 ZNF213 RBAK ZNF354C ZNF433 ZNF202 NSUN5P2 STAG3L3 BAZ1B GTF2IRD2 METTL27 POM121B MIR590 GTF2IRD2P1 LOC101926943 TBL2
GH07I073645 Enhancer 1.4 FANTOM5 Ensembl ENCODE 30.2 -544.3 -544286 3.7 MLX ARID4B ZNF48 YY1 SLC30A9 GLIS2 SP3 RXRA SP5 NFYC NSUN5P2 POM121 STAG3L3 GTF2IRD2P1 MIR590 METTL27 POM121B BAZ1B VPS37D DNAJC30
GH07I073736 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.8 -450.5 -450473 7.8 CLOCK ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 ZNF610 GLIS1 ABHD11 GC07P073741 GC07P073742 METTL27 ABHD11-AS1 POM121B POM121 STAG3L3 NSUN5P2 TBL2
GH07I074252 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 15.2 +64.0 63981 4.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 RFC2 GC07M074256 GC07P074254 POM121B MIR590 NSUN5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR590 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR590 Gene

Genomic Locations for MIR590 Gene
chr7:74,191,198-74,191,294
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr7:73,605,528-73,605,624
(GRCh37/hg19)

Genomic View for MIR590 Gene

Genes around MIR590 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR590 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR590 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR590 Gene

Proteins for MIR590 Gene

Post-translational modifications for MIR590 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR590 Gene

Domains & Families for MIR590 Gene

Gene Families for MIR590 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR590: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR590 Gene

Function for MIR590 Gene

Phenotypes From GWAS Catalog for MIR590 Gene

Gene Ontology (GO) - Molecular Function for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 19398468
genes like me logo Genes that share ontologies with MIR590: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR590 Gene

Localization for MIR590 Gene

Gene Ontology (GO) - Cellular Components for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR590: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR590 Gene

Pathways & Interactions for MIR590 Gene

SuperPathways for MIR590 Gene

No Data Available

Interacting Proteins for MIR590 Gene

Gene Ontology (GO) - Biological Process for MIR590 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 24288179
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 26459119
GO:0030335 positive regulation of cell migration IDA 24288179
GO:0035195 gene silencing by miRNA IDA 23598417
GO:0035278 miRNA mediated inhibition of translation IDA 19398468
genes like me logo Genes that share ontologies with MIR590: view

No data available for Pathways by source and SIGNOR curated interactions for MIR590 Gene

Drugs & Compounds for MIR590 Gene

No Compound Related Data Available

Transcripts for MIR590 Gene

mRNA/cDNA for MIR590 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR590 Gene

No ASD Table

Relevant External Links for MIR590 Gene

GeneLoc Exon Structure for
MIR590
ECgene alternative splicing isoforms for
MIR590

Expression for MIR590 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR590 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR590 Gene:

MIR590
genes like me logo Genes that share expression patterns with MIR590: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR590 Gene

Orthologs for MIR590 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR590 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-590 34
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-590 34
  • 69 (a)
OneToOne
Species where no ortholog for MIR590 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR590 Gene

ENSEMBL:
Gene Tree for MIR590 (if available)
TreeFam:
Gene Tree for MIR590 (if available)

Paralogs for MIR590 Gene

No data available for Paralogs for MIR590 Gene

Variants for MIR590 Gene

Sequence variations from dbSNP and Humsavar for MIR590 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1002641739 -- 74,190,772(+) G/A upstream_transcript_variant
rs1003102510 -- 74,190,526(+) G/A upstream_transcript_variant
rs1005645334 -- 74,191,389(+) C/T downstream_transcript_variant
rs1005930864 -- 74,190,511(+) C/G upstream_transcript_variant
rs1008393211 -- 74,190,138(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR590 Gene

Variant ID Type Subtype PubMed ID
esv3613698 CNV loss 21293372
nsv464563 CNV gain 19166990
nsv607480 CNV gain 21841781
nsv831030 CNV gain 17160897

Additional Variant Information for MIR590 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR590

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR590 Gene

Disorders for MIR590 Gene

Additional Disease Information for MIR590

No disorders were found for MIR590 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR590 Gene

Publications for MIR590 Gene

  1. MicroRNA-590-5p Stabilizes Runx2 by Targeting Smad7 During Osteoblast Differentiation. (PMID: 27192628) Vishal M … Selvamurugan N (Journal of cellular physiology 2017) 3 58
  2. [miR-590-5p inhibits A375 cell invasion and migration in malignant melanoma by directly inhibiting YAP1 expression]. (PMID: 28274310) Wang L … Mu K (Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2017) 3 58
  3. MicroRNA-590-3p promotes cell proliferation and invasion by targeting inositol polyphosphate 4-phosphatase type II in human prostate cancer cells. (PMID: 28345464) Chen H … Li H (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  4. MiR-590-3p suppresses hepatocellular carcinoma growth by targeting TEAD1. (PMID: 28349829) Ge X … Gong L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  5. MiR-590-5p, a density-sensitive microRNA, inhibits tumorigenesis by targeting YAP1 in colorectal cancer. (PMID: 28433598) Ou C … Ma J (Cancer letters 2017) 3 58

Products for MIR590 Gene

Sources for MIR590 Gene

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