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Aliases for MIR590 Gene

Subcategory (RNA class) for MIR590 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR590 Gene

  • MicroRNA 590 2 3 5
  • Hsa-Mir-590 3
  • Mir-590 3
  • MIRN590 3

External Ids for MIR590 Gene

ORGUL Members for MIR590 Gene

Previous HGNC Symbols for MIR590 Gene

  • MIRN590

Previous GeneCards Identifiers for MIR590 Gene

  • GC07P073244
  • GC07P073605

Summaries for MIR590 Gene

Entrez Gene Summary for MIR590 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR590 Gene

MIR590 (MicroRNA 590) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR590 Gene

Genomics for MIR590 Gene

Regulatory Elements for MIR590 Gene

Enhancers for MIR590 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F074635 1.6 FANTOM5 Ensembl ENCODE 43.1 +444.8 444819 2.0 PKNOX1 ZFP64 ARID4B SIN3A YBX1 ZNF48 FOS ZNF202 REST PPARG STAG3L1 MIR590 WBSCR27 NSUN5P1 GTF2IRD2 WBSCR22 LOC101926943 PMS2P5 TRIM73 PMS2P2
GH07F073890 1.2 FANTOM5 Ensembl ENCODE 47.9 -300.8 -300797 0.8 ZNF202 ZNF680 ZNF140 ZBTB8A REST ZNF781 ZNF518A ZNF664 ZNF292 ZNF791 BAZ1B GTF2IRD2 WBSCR27 POM121B MIR590 GTF2IRD2P1 LOC101926943 WBSCR22 PMS2P7 FKBP6
GH07F074472 1.6 FANTOM5 Ensembl ENCODE 23.9 +287.6 287623 11.7 PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 YBX1 FOS JUNB ZHX2 STAG3L1 BAZ1B WBSCR27 NSUN5P1 GTF2IRD2 MIR590 LOC101926943 GTF2IRD1 WBSCR22 TRIM73
GH07F073645 1.5 FANTOM5 Ensembl ENCODE 24.8 -544.3 -544286 3.7 MLX ARID4B ZNF48 YY1 SLC30A9 GLIS2 ZNF263 SP3 SP5 NFYC MIR590 POM121 GTF2IRD2P1 WBSCR27 BAZ1B VPS37D DNAJC30 WBSCR22 POM121B MLXIPL
GH07F073682 1.1 ENCODE 25.8 -507.9 -507861 2.5 HDGF PKNOX1 ATF1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 BRCA1 POM121 MIR590 POM121B GTF2IRD2P1 RFC2 ABHD11-AS1 DNAJC30 VPS37D WBSCR22
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR590 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR590 Gene

Chromosome:
7
Start:
74,191,198 bp from pter
End:
74,191,294 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR590 Gene

Genes around MIR590 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR590 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR590 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR590 Gene

Proteins for MIR590 Gene

Post-translational modifications for MIR590 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR590 Gene

Domains & Families for MIR590 Gene

Gene Families for MIR590 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR590: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR590 Gene

Function for MIR590 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR590 Gene

Localization for MIR590 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR590 Gene

Pathways & Interactions for MIR590 Gene

SuperPathways for MIR590 Gene

No Data Available

Interacting Proteins for MIR590 Gene

Gene Ontology (GO) - Biological Process for MIR590 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR590 Gene

Transcripts for MIR590 Gene

mRNA/cDNA for MIR590 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR590 Gene

No ASD Table

Relevant External Links for MIR590 Gene

GeneLoc Exon Structure for
MIR590
ECgene alternative splicing isoforms for
MIR590

Expression for MIR590 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR590 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR590 Gene:

MIR590
genes like me logo Genes that share expression patterns with MIR590: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR590 Gene

Orthologs for MIR590 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR590 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-590 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-590 35
  • 69 (a)
OneToOne
Species where no ortholog for MIR590 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR590 Gene

ENSEMBL:
Gene Tree for MIR590 (if available)
TreeFam:
Gene Tree for MIR590 (if available)

Paralogs for MIR590 Gene

No data available for Paralogs for MIR590 Gene

Variants for MIR590 Gene

Sequence variations from dbSNP and Humsavar for MIR590 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10246030 -- 74,190,597(+) CCCAG(A/G)GAAAC intron-variant, upstream-variant-2KB
rs111325255 -- 74,191,378(+) GTTGC(A/C/T)CACAT intron-variant, downstream-variant-500B
rs111412030 -- 74,191,606(+) GGTGC(A/T)ATTTT intron-variant, downstream-variant-500B
rs112977935 -- 74,190,930(+) TGCAC(A/G)TGATA intron-variant, upstream-variant-2KB
rs113866177 -- 74,191,728(+) GAAAA(C/G)TCTGA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR590 Gene

Variant ID Type Subtype PubMed ID
esv3613698 CNV loss 21293372
nsv464563 CNV gain 19166990
nsv607480 CNV gain 21841781
nsv831030 CNV gain 17160897

Relevant External Links for MIR590 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR590

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR590 Gene

Disorders for MIR590 Gene

Relevant External Links for MIR590

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR590

No disorders were found for MIR590 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR590 Gene

Publications for MIR590 Gene

  1. miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p. (PMID: 26498065) Yang X. … Wu X. (Oncol. Rep. 2016) 3 64
  2. Effects of miRa89590 on oxLDLa89induced endothelial cell apoptosis: Roles of p53 and NFa89I_B. (PMID: 26648441) Bao M.H. … Zhang Y.W. (Mol Med Rep 2016) 3 64
  3. MiR-590-5p-meidated LOX-1 upregulation promotes Angiotensin II-induced endothelial cell apoptosis. (PMID: 26906623) Luo P. … Zhang Z. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. Inhibitory effect of hsa-miR-590-5p on cardiosphere-derived stem cells differentiation through downregulation of TGFB signaling. (PMID: 25163461) Ekhteraei-Tousi S. … Soleimani M. (J. Cell. Biochem. 2015) 3 64
  5. MicroRNA-590 is an EMT-suppressive microRNA involved in the TGFI^ signaling pathway. (PMID: 26459119) Liu T. … Weng Y. (Mol Med Rep 2015) 3 64

Products for MIR590 Gene

Sources for MIR590 Gene

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