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Aliases for MIR589 Gene

Subcategory (RNA class) for MIR589 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR589 Gene

  • MicroRNA 589 2 3 5
  • Hsa-Mir-589 3
  • Mir-589 3
  • MIRN589 3

External Ids for MIR589 Gene

Previous HGNC Symbols for MIR589 Gene

  • MIRN589

Previous GeneCards Identifiers for MIR589 Gene

  • GC07M005502
  • GC07M005535

Summaries for MIR589 Gene

Entrez Gene Summary for MIR589 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR589 Gene

MIR589 (MicroRNA 589) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR589 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR589

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR589 Gene

Genomics for MIR589 Gene

Regulatory Elements for MIR589 Gene

Enhancers for MIR589 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F005702 1.2 Ensembl ENCODE 12.7 -208.0 -208024 2.6 ELF3 ARID4B RAD21 RFX5 ZNF143 FOS CREM MIXL1 ZNF654 REST C7orf26 ZNF316 RNF216P1 USP42 FBXL18 MIR589 ACTB FSCN1 MIR6874 RNF216-IT1
GH07F005561 0.5 ENCODE 12.5 -66.9 -66931 2.6 CREB3L1 ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS SP3 SP5 NFYC KDELR2 FBXL18 MIR589 FSCN1 ACTB LOC100288712
GH07F005687 1.5 FANTOM5 Ensembl ENCODE 12.4 -198.7 -198710 15.2 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A BMI1 FEZF1 EGR1 FOS ENSG00000198580 ENSG00000228010 ACTB FBXL18 MIR589 FSCN1 RNF216 WIPI2 USP42 CCZ1
GH07F005665 0.8 Ensembl ENCODE 12.2 -169.6 -169585 0.6 CTCF ESRRA SAP130 ARNT ARID4B BACH1 RAD21 ZKSCAN1 ZNF143 SMC3 ACTB FSCN1 FBXL18 MIR589 TNRC18 LOC100129484 RNF216-IT1
GH07F005666 0.8 Ensembl ENCODE 12.1 -171.6 -171574 1.4 IKZF1 CEBPB REST ZBTB20 ZNF18 NR2F2 ACTB FBXL18 MIR589 FSCN1 LOC100129484 TNRC18 RNF216-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR589 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR589 Gene

Chromosome:
7
Start:
5,495,819 bp from pter
End:
5,495,917 bp from pter
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR589 Gene

Genes around MIR589 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR589 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR589 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR589 Gene

ORGUL Member Location for MIR589 Gene

ORGUL Member Location for MIR589 gene

Proteins for MIR589 Gene

Post-translational modifications for MIR589 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR589 Gene

Domains & Families for MIR589 Gene

Gene Families for MIR589 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR589: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR589 Gene

Function for MIR589 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR589 Gene

Localization for MIR589 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR589 Gene

Pathways & Interactions for MIR589 Gene

SuperPathways for MIR589 Gene

No Data Available

Interacting Proteins for MIR589 Gene

Gene Ontology (GO) - Biological Process for MIR589 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR589 Gene

Transcripts for MIR589 Gene

fRNAdb Secondary structures for MIR589 Gene

  • hsa-miR-589-3p_MIMAT0003256_Homo_sapiens_miR-589-3p_mature

mRNA/cDNA for MIR589 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR589 Gene

No ASD Table

Relevant External Links for MIR589 Gene

GeneLoc Exon Structure for
MIR589
ECgene alternative splicing isoforms for
MIR589

Expression for MIR589 Gene

mRNA expression in normal human tissues for MIR589 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR589 Gene:

MIR589
genes like me logo Genes that share expression patterns with MIR589: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR589 Gene

Orthologs for MIR589 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR589 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-589 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-589 35
  • 79 (a)
OneToOne
Species where no ortholog for MIR589 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR589 Gene

ENSEMBL:
Gene Tree for MIR589 (if available)
TreeFam:
Gene Tree for MIR589 (if available)

Paralogs for MIR589 Gene

No data available for Paralogs for MIR589 Gene

Variants for MIR589 Gene

Sequence variations from dbSNP and Humsavar for MIR589 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10215432 -- 5,497,146(+) gcagt(A/G)agctg intron-variant, upstream-variant-2KB
rs10951958 -- 5,497,574(+) TGGCC(A/G)GGGGA intron-variant, upstream-variant-2KB
rs112631934 -- 5,496,556(+) GCTTG(C/G)CTTAG intron-variant, upstream-variant-2KB
rs113017753 -- 5,496,748(+) CGGCC(A/G)GGCAC intron-variant, upstream-variant-2KB
rs113577177 -- 5,496,077(+) CCGGA(G/T)GCCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR589 Gene

Variant ID Type Subtype PubMed ID
dgv3482n106 OTHER inversion 24896259
nsv436904 CNV insertion 17901297
nsv471304 CNV loss 18288195
nsv517558 CNV loss 19592680
nsv526194 CNV gain 19592680
nsv830890 CNV loss 17160897

Relevant External Links for MIR589 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR589

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR589 Gene

Disorders for MIR589 Gene

Relevant External Links for MIR589

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR589

No disorders were found for MIR589 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR589 Gene

Publications for MIR589 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Microarray based analysis of gene regulation by microRNA in intervertebral disc degeneration. (PMID: 26134418) Hu P. … Jia T. (Mol Med Rep 2015) 3 64
  3. Common variants in left/right asymmetry genes and pathways are associated with relative hand skill. (PMID: 24068947) Brandler W.M. … Paracchini S. (PLoS Genet. 2013) 3 64
  4. miRNA589 regulates epithelial-mesenchymal transition in human peritoneal mesothelial cells. (PMID: 23118514) Zhang K. … Liu F.Y. (J. Biomed. Biotechnol. 2012) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR589 Gene

Sources for MIR589 Gene

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