Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR588 Gene

Subcategory (RNA class) for MIR588 Gene


Quality Score for this RNA gene is


Aliases for MIR588 Gene

  • MicroRNA 588 2 3 5
  • Hsa-Mir-588 3
  • MIRN588 3

External Ids for MIR588 Gene

ORGUL Members for MIR588 Gene

Previous HGNC Symbols for MIR588 Gene

  • MIRN588

Previous GeneCards Identifiers for MIR588 Gene

  • GC06P126848

Summaries for MIR588 Gene

Entrez Gene Summary for MIR588 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR588 Gene

MIR588 (MicroRNA 588) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR588 include Lung Squamous Cell Carcinoma.

Additional gene information for MIR588 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR588 Gene

Genomics for MIR588 Gene

Genomic Locations for MIR588 Gene

Genomic Locations for MIR588 Gene
83 bases
Plus strand

Genomic View for MIR588 Gene

Genes around MIR588 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR588 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR588 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR588 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR588 Gene

Proteins for MIR588 Gene

Post-translational modifications for MIR588 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR588 Gene

Domains & Families for MIR588 Gene

Gene Families for MIR588 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR588: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR588 Gene

Function for MIR588 Gene

Phenotypes From GWAS Catalog for MIR588 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR588 Gene

Localization for MIR588 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR588 Gene

Pathways & Interactions for MIR588 Gene

SuperPathways for MIR588 Gene

No Data Available

Interacting Proteins for MIR588 Gene

Gene Ontology (GO) - Biological Process for MIR588 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR588 Gene

Drugs & Compounds for MIR588 Gene

No Compound Related Data Available

Transcripts for MIR588 Gene

mRNA/cDNA for MIR588 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR588 Gene

No ASD Table

Relevant External Links for MIR588 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR588 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR588 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR588 Gene:

genes like me logo Genes that share expression patterns with MIR588: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR588 Gene

Orthologs for MIR588 Gene

Evolution for MIR588 Gene

Gene Tree for MIR588 (if available)
Gene Tree for MIR588 (if available)

No data available for Orthologs for MIR588 Gene

Paralogs for MIR588 Gene

No data available for Paralogs for MIR588 Gene

Variants for MIR588 Gene

Sequence variations from dbSNP and Humsavar for MIR588 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1002830840 -- 126,483,848(+) C/G upstream_transcript_variant
rs1003185791 -- 126,484,302(+) G/A upstream_transcript_variant
rs1004696864 -- 126,483,839(+) TTTTT/TTTTTTTT upstream_transcript_variant
rs1004727780 -- 126,484,204(+) G/A/T upstream_transcript_variant
rs1006956016 -- 126,483,994(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR588 Gene

Variant ID Type Subtype PubMed ID
nsv970162 CNV duplication 23825009

Additional Variant Information for MIR588 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR588 Gene

Disorders for MIR588 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR588 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR588

genes like me logo Genes that share disorders with MIR588: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR588 Gene

Publications for MIR588 Gene

  1. MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma. (PMID: 27571908) Qian L … Liu X (Molecular medicine reports 2016) 3 58
  2. Genetic predictors of medically refractory ulcerative colitis. (PMID: 20848476) Haritunians T … McGovern DP (Inflammatory bowel diseases 2010) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58

Products for MIR588 Gene

Sources for MIR588 Gene

Loading form....