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Aliases for MIR585 Gene

Subcategory (RNA class) for MIR585 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR585 Gene

  • MicroRNA 585 2 3 5
  • Hsa-Mir-585 3
  • Mir-585 3
  • MIRN585 3

External Ids for MIR585 Gene

Previous HGNC Symbols for MIR585 Gene

  • MIRN585

Previous GeneCards Identifiers for MIR585 Gene

  • GC05M168625

Summaries for MIR585 Gene

Entrez Gene Summary for MIR585 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR585 Gene

MIR585 (MicroRNA 585) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR585 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR585

Additional gene information for MIR585 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR585 Gene

Genomics for MIR585 Gene

GeneHancer (GH) Regulatory Elements for MIR585 Gene

Promoters and enhancers for MIR585 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I169299 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 10.2 -37.8 -37786 3.1 PKNOX1 ZSCAN4 KLF17 SIN3A ZNF2 RAD21 ZNF335 GLIS2 ZNF366 ZSCAN5C SLIT3 MIR585 LOC105377715
GH05I169267 Enhancer 0.5 ENCODE 0.8 -4.5 -4461 1.1 ATF4 L3MBTL2 CEBPG FEZF1 SLIT3 MIR585
GH05I169163 Enhancer 1 Ensembl ENCODE dbSUPER 0.2 +98.9 98946 2.5 KLF17 SIN3A BACH1 SP1 ZNF664 JUND ATF3 POLR2A CTBP2 ZBTB33 GC05M169154 MIR585 SLIT3
GH05I169296 Enhancer 0.5 ENCODE 0.3 -33.1 -33066 1.4 CHD4 PRDM10 NR2F2 EZH2 SLIT3 MIR585
GH05I169159 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.1 +102.2 102218 3 CTCF PKNOX1 FOXA2 ZNF449 JUN KLF17 SIN3A ZNF384 FEZF1 ZIC2 GC05M169154 MIR585 SLIT3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR585 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR585 Gene

Genomic Locations for MIR585 Gene
chr5:169,263,601-169,263,694
(GRCh38/hg38)
Size:
94 bases
Orientation:
Minus strand
chr5:168,690,605-168,690,698
(GRCh37/hg19)

Genomic View for MIR585 Gene

Genes around MIR585 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR585 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR585 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR585 Gene

ORGUL Member Location for MIR585 Gene

ORGUL Member Location for MIR585 gene

Proteins for MIR585 Gene

Post-translational modifications for MIR585 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR585 Gene

Domains & Families for MIR585 Gene

Gene Families for MIR585 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR585: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR585 Gene

Function for MIR585 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR585 Gene

Localization for MIR585 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR585 Gene

Pathways & Interactions for MIR585 Gene

SuperPathways for MIR585 Gene

No Data Available

Interacting Proteins for MIR585 Gene

Gene Ontology (GO) - Biological Process for MIR585 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR585 Gene

Drugs & Compounds for MIR585 Gene

No Compound Related Data Available

Transcripts for MIR585 Gene

fRNAdb Secondary structures for MIR585 Gene

  • hsa-miR-585-5p_MIMAT0026618_Homo_sapiens_miR-585-5p_mature
  • hsa-mir-585_MI0003592_Homo_sapiens_miR-585_stem-loop_hairpin

mRNA/cDNA for MIR585 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR585 Gene

No ASD Table

Relevant External Links for MIR585 Gene

GeneLoc Exon Structure for
MIR585
ECgene alternative splicing isoforms for
MIR585

Expression for MIR585 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR585 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR585 Gene:

MIR585
genes like me logo Genes that share expression patterns with MIR585: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR585 Gene

Orthologs for MIR585 Gene

Evolution for MIR585 Gene

ENSEMBL:
Gene Tree for MIR585 (if available)
TreeFam:
Gene Tree for MIR585 (if available)

No data available for Orthologs for MIR585 Gene

Paralogs for MIR585 Gene

No data available for Paralogs for MIR585 Gene

Variants for MIR585 Gene

Sequence variations from dbSNP and Humsavar for MIR585 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000257576 -- 169,263,668(-) T/C non_coding_transcript_variant
rs1003459520 -- 169,264,319(-) G/A upstream_transcript_variant
rs1004828222 -- 169,265,299(-) A/T upstream_transcript_variant
rs1004929627 -- 169,265,081(-) G/A upstream_transcript_variant
rs1006436030 -- 169,265,341(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR585 Gene

Variant ID Type Subtype PubMed ID
nsv1016765 CNV gain 25217958

Additional Variant Information for MIR585 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR585

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR585 Gene

Disorders for MIR585 Gene

Additional Disease Information for MIR585

No disorders were found for MIR585 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR585 Gene

Publications for MIR585 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MicroRNA-585 acts as a tumor suppressor in non-small-cell lung cancer by targeting hSMG-1. (PMID: 27743168) Ding X … Zhou X (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2017) 3 58
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR585 Gene

Sources for MIR585 Gene

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