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Aliases for MIR584 Gene

Subcategory (RNA class) for MIR584 Gene


Quality Score for this RNA gene is


Aliases for MIR584 Gene

  • MicroRNA 584 2 3 5
  • Hsa-Mir-584 3
  • MIRN584 3

External Ids for MIR584 Gene

Previous HGNC Symbols for MIR584 Gene

  • MIRN584

Previous GeneCards Identifiers for MIR584 Gene

  • GC05M148423
  • GC05M148441

Summaries for MIR584 Gene

Entrez Gene Summary for MIR584 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR584 Gene

MIR584 (MicroRNA 584) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR584 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR584

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR584 Gene

Genomics for MIR584 Gene

Regulatory Elements for MIR584 Gene

Enhancers for MIR584 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F149036 1.2 Ensembl ENCODE 12.7 +25.0 25049 2.3 ZNF664 HLF ZMYM3 MAX FOS ZIC2 MYC MGA SH3TC2 RNU6-732P LOC255187 MIR584 AFAP1L1 ABLIM3 GC05M149010 GC05M149060
GH05F149035 0.2 Ensembl 12.7 +26.7 26709 0.6 CTCF WRNIP1 ZMYM3 MAX CEBPG ZNF2 RAD21 ZNF101 ZNF664 ZBTB48 SH3TC2 RNU6-732P LOC255187 MIR584 AFAP1L1 GC05M149010 GC05M149060
GH05F149094 0.7 ENCODE 11.7 -32.8 -32768 1.3 BCOR HDAC1 JUN CEBPG FOSL1 SMARCE1 ZNF687 ZNF740 RNF2 CEBPB SH3TC2 LOC255187 MIR584 RNU6-732P AFAP1L1 GC05P149108
GH05F149030 0.2 ENCODE 11.6 +31.6 31629 1.1 BHLHE40 MNT SH3TC2 RNU6-732P LOC255187 MIR584 GC05M149010 GC05M149060
GH05F149113 1.3 Ensembl ENCODE 11.5 -52.1 -52115 1.8 CTCF ZNF654 JUN CEBPB REST EP300 RAD21 JUND ZNF524 SMC3 SH3TC2 LOC255187 MIR584 RNU6-732P AFAP1L1 ENSG00000248647 ENSG00000253406 GC05M149117 RN7SKP145 GC05P149108
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR584 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR584 Gene

149,062,313 bp from pter
149,062,409 bp from pter
97 bases
Minus strand

Genomic View for MIR584 Gene

Genes around MIR584 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR584 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR584 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR584 Gene

ORGUL Member Location for MIR584 Gene

ORGUL Member Location for MIR584 gene

Proteins for MIR584 Gene

Post-translational modifications for MIR584 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR584 Gene

Domains & Families for MIR584 Gene

Gene Families for MIR584 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR584: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR584 Gene

Function for MIR584 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR584 Gene

Localization for MIR584 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR584 Gene

Pathways & Interactions for MIR584 Gene

SuperPathways for MIR584 Gene

No Data Available

Interacting Proteins for MIR584 Gene

Gene Ontology (GO) - Biological Process for MIR584 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR584 Gene

Transcripts for MIR584 Gene

fRNAdb Secondary structures for MIR584 Gene

  • FR340342
  • hsa-miR-584-3p_MIMAT0022708_Homo_sapiens_miR-584-3p_mature

mRNA/cDNA for MIR584 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR584 Gene

No ASD Table

Relevant External Links for MIR584 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR584 Gene

mRNA expression in normal human tissues for MIR584 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR584 Gene:

genes like me logo Genes that share expression patterns with MIR584: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR584 Gene

Orthologs for MIR584 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR584 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-584 35
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-584-3 35
  • 68 (a)
(Canis familiaris)
Mammalia -- 35
  • 61 (a)
Species where no ortholog for MIR584 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR584 Gene

Gene Tree for MIR584 (if available)
Gene Tree for MIR584 (if available)

Paralogs for MIR584 Gene

No data available for Paralogs for MIR584 Gene

Variants for MIR584 Gene

Sequence variations from dbSNP and Humsavar for MIR584 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs80338918 Pathogenic 149,062,995(-) CCAGG(-/G)AGCGG upstream-variant-2KB, reference, frameshift-variant
rs864309709 Likely pathogenic 149,063,022(-) CACAC(A/G)TGGGT upstream-variant-2KB, reference, missense
rs879254057 Likely pathogenic 149,062,966(-) AGGTG(-/AG)TTTCC intron-variant, upstream-variant-2KB
rs149762843 Uncertain significance 149,062,992(+) ACTCC(A/G/T)CTCCC upstream-variant-2KB, reference, synonymous-codon, missense
rs10054699 -- 149,063,787(+) taggg(C/G)gacta intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR584 Gene

Variant ID Type Subtype PubMed ID
nsv830517 CNV gain 17160897

Relevant External Links for MIR584 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR584 Gene

Disorders for MIR584 Gene

Relevant External Links for MIR584

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR584 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR584 Gene

Publications for MIR584 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. MicroRNA-584-3p, a novel tumor suppressor and prognostic marker, reduces the migration and invasion of human glioma cells by targeting hypoxia-induced ROCK1. (PMID: 26715733) Xue H. … Li G. (Oncotarget 2016) 3 64
  3. miR-584 Suppresses Invasion and Cell Migration of Thyroid Carcinoma by Regulating the Target Oncogene ROCK1. (PMID: 26405762) Xiang J. … Wang Y.J. (Oncol Res Treat 2015) 3 64
  4. microRNA-26a and -584 inhibit the colorectal cancer progression through inhibition of the binding of hnRNP A1-CDK6 mRNA. (PMID: 26494299) Konishi H. … Kohgo Y. (Biochem. Biophys. Res. Commun. 2015) 3 64
  5. Upregulation of microRNAa89335 and microRNAa89584 contributes to the pathogenesis of severe preeclampsia through downregulation of endothelial nitric oxide synthase. (PMID: 26133786) Jiang F. … Wang X. (Mol Med Rep 2015) 3 64

Products for MIR584 Gene

Sources for MIR584 Gene

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