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Aliases for MIR584 Gene

Subcategory (RNA class) for MIR584 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR584 Gene

  • MicroRNA 584 2 3
  • Hsa-Mir-584 3
  • MIRN584 3

External Ids for MIR584 Gene

Previous HGNC Symbols for MIR584 Gene

  • MIRN584

Previous GeneCards Identifiers for MIR584 Gene

  • GC05M148423
  • GC05M148441

Summaries for MIR584 Gene

Entrez Gene Summary for MIR584 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR584 Gene

MIR584 (MicroRNA 584) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR584 include clear cell renal cell carcinoma and renal cell carcinoma.

fRNAdb sequence ontologies for MIR584 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR584

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR584 Gene

Genomics for MIR584 Gene

Genomic Location for MIR584 Gene

Start:
149,062,304 bp from pter
End:
149,062,414 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR584 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR584 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR584 Gene

ORGUL Member Location for MIR584 Gene

ORGUL Member Location for MIR584 gene

No data available for Regulatory Elements for MIR584 Gene

Proteins for MIR584 Gene

Post-translational modifications for MIR584 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR584 Gene

Domains for MIR584 Gene

Gene Families for MIR584 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR584: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR584 Gene

Function for MIR584 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR584 Gene

Localization for MIR584 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR584 Gene

Pathways for MIR584 Gene

SuperPathways for MIR584 Gene

No Data Available

Interacting Proteins for MIR584 Gene

Gene Ontology (GO) - Biological Process for MIR584 Gene

None

No data available for Pathways by source for MIR584 Gene

Transcripts for MIR584 Gene

fRNAdb Secondary structures for MIR584 Gene

  • FR340342
  • hsa-miR-584-3p_MIMAT0022708_Homo_sapiens_miR-584-3p_mature

mRNA/cDNA for MIR584 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR584

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR584 Gene

No ASD Table

Relevant External Links for MIR584 Gene

GeneLoc Exon Structure for
MIR584
ECgene alternative splicing isoforms for
MIR584

Expression for MIR584 Gene

mRNA expression in normal human tissues for MIR584 Gene

genes like me logo Genes that share expressions with MIR584: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR584 Gene

Orthologs for MIR584 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR584 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-584 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-584-3 36
  • 68 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
ManyToMany
Species with no ortholog for MIR584:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR584 Gene

ENSEMBL:
Gene Tree for MIR584 (if available)
TreeFam:
Gene Tree for MIR584 (if available)

Paralogs for MIR584 Gene

No data available for Paralogs for MIR584 Gene

Variants for MIR584 Gene

Relevant External Links for MIR584 Gene

HapMap Linkage Disequilibrium report
MIR584

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR584 Gene

Disorders for MIR584 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MIR584 Gene including...

Search for MIR584 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR584: view

No data available for UniProtKB/Swiss-Prot for MIR584 Gene

Publications for MIR584 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  5. miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period. (PMID: 19665576) Liao Y. … LAPnnerdal B. (Int. J. Biochem. Cell Biol. 2010) 3

Products for MIR584 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR584
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR584
    • Block miRNA regulation of MIR584 using miScript Target Protectors

    Sources for MIR584 Gene

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