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Aliases for MIR583 Gene

Subcategory (RNA class) for MIR583 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR583 Gene

  • MicroRNA 583 2 3 5
  • Hsa-Mir-583 3
  • MIRN583 3

External Ids for MIR583 Gene

ORGUL Members for MIR583 Gene

Previous HGNC Symbols for MIR583 Gene

  • MIRN583

Previous GeneCards Identifiers for MIR583 Gene

  • GC05P095441

Summaries for MIR583 Gene

Entrez Gene Summary for MIR583 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR583 Gene

MIR583 (MicroRNA 583) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR583 Gene

Genomics for MIR583 Gene

Regulatory Elements for MIR583 Gene

Enhancers for MIR583 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G096112 1.1 ENCODE dbSUPER 10.7 +35.5 35544 3.6 SOX13 ZMYM3 FEZF1 CEBPG RAD21 ZNF7 YY1 GATA2 FOS PRDM10 MIR583 GC05M096211 RNU6-524P
GH05G096077 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +0.6 618 4.1 HDAC1 TBP PKNOX1 TCF12 GATA2 FOS CEBPB ZNF398 MTA1 SMARCA4 ELL2 GLRX MIR583 RNU6-524P GC05M096211
GH05G096082 1.5 FANTOM5 ENCODE dbSUPER 0.7 +4.9 4862 2.1 PKNOX1 ZFP64 INSM2 ZNF76 KLF17 FEZF1 ZNF2 ZNF121 ZNF366 ZSCAN5C ELL2 MIR583 GC05M096211 RNU6-524P
GH05G096085 1.2 FANTOM5 ENCODE dbSUPER 0.4 +6.2 6189 0.2 ZSCAN21 ZNF639 PRDM6 ZNF366 ZNF629 BCL6B CEBPB FEZF1 SP7 ELL2 GLRX MIR583 RNU6-524P GC05M096211
GH05G096092 1.1 ENCODE dbSUPER 0.4 +15.0 14959 2.8 FOXA2 NFIB JUN CEBPG BRCA1 RAD21 RFX5 YY1 ZNF316 GATA3 MIR583 GC05M096211 RNU6-524P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR583 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR583 Gene

Chromosome:
5
Start:
96,079,138 bp from pter
End:
96,079,212 bp from pter
Size:
75 bases
Orientation:
Plus strand

Genomic View for MIR583 Gene

Genes around MIR583 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR583 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR583 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR583 Gene

Proteins for MIR583 Gene

Post-translational modifications for MIR583 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR583 Gene

Domains & Families for MIR583 Gene

Gene Families for MIR583 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR583: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR583 Gene

Function for MIR583 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR583 Gene

Localization for MIR583 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR583 Gene

Pathways & Interactions for MIR583 Gene

SuperPathways for MIR583 Gene

No Data Available

Interacting Proteins for MIR583 Gene

Gene Ontology (GO) - Biological Process for MIR583 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR583 Gene

Drugs & Compounds for MIR583 Gene

No Compound Related Data Available

Transcripts for MIR583 Gene

mRNA/cDNA for MIR583 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR583 Gene

No ASD Table

Relevant External Links for MIR583 Gene

GeneLoc Exon Structure for
MIR583
ECgene alternative splicing isoforms for
MIR583

Expression for MIR583 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR583 Gene:

MIR583
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR583 Gene

Orthologs for MIR583 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR583 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-583 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR583 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR583 Gene

ENSEMBL:
Gene Tree for MIR583 (if available)
TreeFam:
Gene Tree for MIR583 (if available)

Paralogs for MIR583 Gene

No data available for Paralogs for MIR583 Gene

Variants for MIR583 Gene

Sequence variations from dbSNP and Humsavar for MIR583 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000744801 -- 96,078,419(+) ACGGA(A/G)TTTTG intron-variant, upstream-variant-2KB
rs1002185144 -- 96,079,537(+) AACTC(A/T)TATTT intron-variant, downstream-variant-500B
rs1003810341 -- 96,077,147(+) AGTAT(A/G)TTTTA intron-variant, upstream-variant-2KB
rs1004161348 -- 96,079,301(+) TTACT(C/T)ATTTG intron-variant, downstream-variant-500B
rs1004193927 -- 96,079,536(+) TAACT(A/C)TTATT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR583 Gene

Variant ID Type Subtype PubMed ID
dgv1113e214 CNV gain 21293372
dgv348n21 CNV loss 19592680
esv2759355 CNV gain 17122850
esv34203 CNV gain 17911159
nsv1021263 CNV loss 25217958
nsv4923 CNV insertion 18451855
nsv823146 CNV gain 20364138

Relevant External Links for MIR583 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR583

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR583 Gene

Disorders for MIR583 Gene

Relevant External Links for MIR583

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR583

No disorders were found for MIR583 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR583 Gene

Publications for MIR583 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR583 Gene

Sources for MIR583 Gene

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