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Aliases for MIR582 Gene

Subcategory (RNA class) for MIR582 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR582 Gene

  • MicroRNA 582 2 3 5
  • Hsa-Mir-582 3
  • MIRN582 3

External Ids for MIR582 Gene

Previous HGNC Symbols for MIR582 Gene

  • MIRN582

Previous GeneCards Identifiers for MIR582 Gene

  • GC05M059036
  • GC05M058999

Summaries for MIR582 Gene

Entrez Gene Summary for MIR582 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR582 Gene

MIR582 (MicroRNA 582) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR582 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR582

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR582 Gene

Genomics for MIR582 Gene

Regulatory Elements for MIR582 Gene

Enhancers for MIR582 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G059743 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -41.6 -41575 4.0 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 FEZF1 ZNF2 CBX5 FOS ZNF263 MIR582 PDE4D GC05P059769
GH05G059756 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -55.4 -55407 6.0 PKNOX1 FOXA2 ZSCAN4 INSM2 SIN3A FEZF1 ZBTB40 RAD21 YY1 GATA2 MIR582 GC05P059769
GH05G059763 1.6 Ensembl ENCODE dbSUPER 11.2 -63.2 -63182 6.6 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 FOS DEK ZNF263 MIR582 GC05P059769
GH05G059792 1.3 Ensembl ENCODE dbSUPER 10.8 -89.5 -89535 1.8 GTF2F1 TBP ZNF146 TAF1 JUN ZSCAN4 ZNF133 MAX RAD21 RFX5 MIR582 LOC105378988 ENSG00000248935
GH05G059750 1.2 Ensembl ENCODE dbSUPER 11 -47.8 -47754 1.4 ZNF174 ZBTB21 ZSCAN4 ZEB2 ZNF121 ZNF366 ZSCAN16 GLIS1 ZNF350 HNF4G MIR582 GC05P059769
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR582 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR582 Gene

Chromosome:
5
Start:
59,703,606 bp from pter
End:
59,703,703 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR582 Gene

Genes around MIR582 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR582 Gene

ORGUL Member Location for MIR582 Gene

ORGUL Member Location for MIR582 gene

Proteins for MIR582 Gene

Post-translational modifications for MIR582 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR582 Gene

Domains & Families for MIR582 Gene

Gene Families for MIR582 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR582: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR582 Gene

Function for MIR582 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR582 Gene

Localization for MIR582 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR582 Gene

Pathways & Interactions for MIR582 Gene

SuperPathways for MIR582 Gene

No Data Available

Interacting Proteins for MIR582 Gene

Gene Ontology (GO) - Biological Process for MIR582 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR582 Gene

Drugs & Compounds for MIR582 Gene

No Compound Related Data Available

Transcripts for MIR582 Gene

fRNAdb Secondary structures for MIR582 Gene

  • hsa-miR-582-3p_MIMAT0004797_Homo_sapiens_miR-582-3p_mature

mRNA/cDNA for MIR582 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR582 Gene

No ASD Table

Relevant External Links for MIR582 Gene

GeneLoc Exon Structure for
MIR582
ECgene alternative splicing isoforms for
MIR582

Expression for MIR582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR582 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR582 Gene:

MIR582
genes like me logo Genes that share expression patterns with MIR582: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR582 Gene

Orthologs for MIR582 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR582 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-582 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-582 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir582 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-582 35
  • 93 (a)
OneToOne
Species where no ortholog for MIR582 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR582 Gene

ENSEMBL:
Gene Tree for MIR582 (if available)
TreeFam:
Gene Tree for MIR582 (if available)

Paralogs for MIR582 Gene

No data available for Paralogs for MIR582 Gene

Variants for MIR582 Gene

Sequence variations from dbSNP and Humsavar for MIR582 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000641349 -- 59,704,182(+) CCACA(C/G)AATAT intron-variant, upstream-variant-2KB
rs1000898265 -- 59,704,512(+) CAGCA(C/T)TGACT intron-variant, upstream-variant-2KB
rs1004793748 -- 59,703,863(+) TATTA(C/T)GACAG intron-variant, upstream-variant-2KB
rs1005344030 -- 59,703,127(+) TATGG(C/T)ATGAT intron-variant, downstream-variant-500B
rs1007154755 -- 59,704,675(+) AAACT(A/G)CTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR582 Gene

Variant ID Type Subtype PubMed ID
nsv462190 CNV gain 19166990
nsv462191 CNV loss 19166990
nsv598258 CNV gain 21841781
nsv598259 CNV loss 21841781

Relevant External Links for MIR582 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR582

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR582 Gene

Disorders for MIR582 Gene

Relevant External Links for MIR582

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR582

No disorders were found for MIR582 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR582 Gene

Publications for MIR582 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. (PMID: 27619846) Su M.T. … Kuo P.L. (Biofactors 2017) 3 64
  3. miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. (PMID: 27595705) Shu Z. … Ding D. (World J Surg Oncol 2016) 3 64
  4. Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy. (PMID: 25828868) Nicolas G. … Rovelet-Lecrux A. (Eur. J. Hum. Genet. 2015) 3 64
  5. Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/I^-catenin signalling. (PMID: 26468775) Fang L. … Li M. (Nat Commun 2015) 3 64

Products for MIR582 Gene

Sources for MIR582 Gene

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