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Aliases for MIR582 Gene

Subcategory (RNA class) for MIR582 Gene


Quality Score for this RNA gene is


Aliases for MIR582 Gene

  • MicroRNA 582 2 3 5
  • Hsa-Mir-582 3
  • MIRN582 3

External Ids for MIR582 Gene

Previous HGNC Symbols for MIR582 Gene

  • MIRN582

Previous GeneCards Identifiers for MIR582 Gene

  • GC05M059036
  • GC05M058999

Summaries for MIR582 Gene

Entrez Gene Summary for MIR582 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR582 Gene

MIR582 (MicroRNA 582) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR582 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR582

Additional gene information for MIR582 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR582 Gene

Genomics for MIR582 Gene

GeneHancer (GH) Regulatory Elements for MIR582 Gene

Promoters and enhancers for MIR582 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I059763 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -63.2 -63181 6.6 PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 BRCA1 YY1 ZNF213 DEK LOC105378988 GC05P059769 PDE4D MIR582
GH05I059743 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -41.6 -41574 4 PKNOX1 SIN3A FEZF1 ZNF2 BRCA1 REST TSHZ1 ZNF518A ZNF610 ZSCAN16 MIR582 PDE4D GC05P059769
GH05I059756 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -55.4 -55406 6 PKNOX1 FOXA2 ZSCAN4 INSM2 MZF1 SIN3A FEZF1 ZBTB40 YY1 ZNF335 MIR582 GC05P059769 PDE4D
GH05I059792 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 -89.5 -89534 1.8 JUN ZSCAN4 ZNF133 MAX SIN3A RAD21 RFX5 POLR2A SMARCC2 PRDM10 MIR582 LOC105378988 ENSG00000248935 PDE4D
GH05I059561 Enhancer 1.1 Ensembl ENCODE 10.2 +140.0 139999 4.3 CLOCK SIN3A FEZF1 GLIS2 ELK1 FOS RUNX3 REST TSHZ1 MAFF MIR582 GC05P059529 PDE4D
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR582 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR582 Gene

Genomic Locations for MIR582 Gene
98 bases
Minus strand

Genomic View for MIR582 Gene

Genes around MIR582 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR582 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR582 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR582 Gene

ORGUL Member Location for MIR582 Gene

ORGUL Member Location for MIR582 gene

Proteins for MIR582 Gene

Post-translational modifications for MIR582 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR582 Gene

Domains & Families for MIR582 Gene

Gene Families for MIR582 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR582: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR582 Gene

Function for MIR582 Gene

Gene Ontology (GO) - Molecular Function for MIR582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR582: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR582 Gene

Localization for MIR582 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR582 Gene

Pathways & Interactions for MIR582 Gene

SuperPathways for MIR582 Gene

No Data Available

Interacting Proteins for MIR582 Gene

Gene Ontology (GO) - Biological Process for MIR582 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
genes like me logo Genes that share ontologies with MIR582: view

No data available for Pathways by source and SIGNOR curated interactions for MIR582 Gene

Drugs & Compounds for MIR582 Gene

No Compound Related Data Available

Transcripts for MIR582 Gene

fRNAdb Secondary structures for MIR582 Gene

  • hsa-miR-582-3p_MIMAT0004797_Homo_sapiens_miR-582-3p_mature

mRNA/cDNA for MIR582 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR582 Gene

No ASD Table

Relevant External Links for MIR582 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR582 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR582 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR582 Gene:

genes like me logo Genes that share expression patterns with MIR582: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR582 Gene

Orthologs for MIR582 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR582 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-582 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-582 34
  • 94 (a)
(Mus musculus)
Mammalia Mir582 34
  • 94 (a)
(Bos Taurus)
Mammalia bta-mir-582 34
  • 93 (a)
Species where no ortholog for MIR582 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR582 Gene

Gene Tree for MIR582 (if available)
Gene Tree for MIR582 (if available)

Paralogs for MIR582 Gene

No data available for Paralogs for MIR582 Gene

Variants for MIR582 Gene

Sequence variations from dbSNP and Humsavar for MIR582 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000641349 -- 59,704,182(-) C/G upstream_transcript_variant
rs1000898265 -- 59,704,512(-) T/C upstream_transcript_variant
rs1004793748 -- 59,703,863(-) T/C upstream_transcript_variant
rs1005344030 -- 59,703,127(-) T/C downstream_transcript_variant
rs1007154755 -- 59,704,675(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR582 Gene

Variant ID Type Subtype PubMed ID
nsv462190 CNV gain 19166990
nsv462191 CNV loss 19166990
nsv598258 CNV gain 21841781
nsv598259 CNV loss 21841781

Additional Variant Information for MIR582 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR582 Gene

Disorders for MIR582 Gene

Additional Disease Information for MIR582

No disorders were found for MIR582 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR582 Gene

Publications for MIR582 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. (PMID: 27619846) Su MT … Kuo PL (BioFactors (Oxford, England) 2017) 3 58
  3. miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. (PMID: 27595705) Shu Z … Ding D (World journal of surgical oncology 2016) 3 58
  4. Mutation in the 3'untranslated region of APP as a genetic determinant of cerebral amyloid angiopathy. (PMID: 25828868) Nicolas G … Rovelet-Lecrux A (European journal of human genetics : EJHG 2016) 3 58
  5. miR-582-5p inhibits proliferation of hepatocellular carcinoma by targeting CDK1 and AKT3. (PMID: 26002580) Zhang Y … Ye Q (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015) 3 58

Products for MIR582 Gene

Sources for MIR582 Gene

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