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MIR581 Gene(RNA Gene)

MicroRNA 581

GCID:
GC05M053951
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR581 Gene

Subcategory (RNA class) for MIR581 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR581 Gene

  • MicroRNA 581 2 3 5
  • Hsa-Mir-581 3
  • MIRN581 3

External Ids for MIR581 Gene

ORGUL Members for MIR581 Gene

Previous HGNC Symbols for MIR581 Gene

  • MIRN581

Previous GeneCards Identifiers for MIR581 Gene

  • GC05M053284

Summaries for MIR581 Gene

Entrez Gene Summary for MIR581 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR581 Gene

MIR581 (MicroRNA 581) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR581 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR581 Gene

Genomics for MIR581 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR581 Gene

Enhancers for MIR581 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F053942 1 Ensembl ENCODE 0.4 +8.6 8599 0.4 PKNOX1 TAL1 JUN ZNF175 ZFHX2 NR2F6 TRIM24 CREM SMARCE1 CEBPB MIR581 PIR41245
GH05F054016 1.8 Ensembl ENCODE 0.2 -66.8 -66803 4.2 BCL11A TEAD4 POU5F1 MAFK RN7SL801P MIR581
GH05F053945 0.7 Ensembl 0.4 +6.5 6499 0.2 SOX13 SOX5 ATF1 BHLHE40 ZFP64 PPARG JUND TCF7 CREB1 NR2F6 FST MIR581 PIR41245
GH05F054013 1.4 FANTOM5 Ensembl ENCODE 0.2 -62.1 -62138 1.1 CBX3 JUN BACH1 CHAMP1 ZNF316 CBX5 RCOR1 TRIM24 NFE2 FOS ARL15 RN7SL801P MIR581
GH05F054021 1.4 FANTOM5 Ensembl ENCODE 0.2 -70.5 -70502 1.4 CTCF HDAC1 LEF1 PKNOX1 ESRRA ETV1 ZNF175 IRF9 SCRT2 NR2F6 RN7SL801P MIR581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR581 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR581 Gene

Chromosome:
5
Start:
53,951,504 bp from pter
End:
53,951,599 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR581 Gene

Genes around MIR581 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR581 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR581 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR581 Gene

ORGUL Member Location for MIR581 Gene

ORGUL Member Location for MIR581 gene

Proteins for MIR581 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR581 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR581 Gene

Domains & Families for MIR581 Gene

Gene Families for MIR581 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR581: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR581 Gene

Function for MIR581 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR581 Gene

Localization for MIR581 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR581 Gene

Pathways & Interactions for MIR581 Gene

SuperPathways for MIR581 Gene

PathCards logo More details on SuperPathways for MIR581
No Data Available

Interacting Proteins for MIR581 Gene

Gene Ontology (GO) - Biological Process for MIR581 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR581 Gene

Drugs & Compounds for MIR581 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR581 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MIR581 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR581 Gene

No ASD Table

Relevant External Links for MIR581 Gene

GeneLoc Exon Structure for
MIR581
ECgene alternative splicing isoforms for
MIR581

Expression for MIR581 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR581 Gene

mRNA expression in normal human tissues for MIR581 Gene
mRNA expression by GTEx for MIR581 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR581 Gene:

MIR581
genes like me logo Genes that share expression patterns with MIR581: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR581 Gene

Orthologs for MIR581 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR581 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-581 35
  • 99 (a)
 OneToOne
Species where no ortholog for MIR581 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR581 Gene

ENSEMBL:
Gene Tree for MIR581 (if available)
TreeFam:
Gene Tree for MIR581 (if available)

Paralogs for MIR581 Gene

No data available for Paralogs for MIR581 Gene

Variants for MIR581 Gene

Sequence variations from dbSNP and Humsavar for MIR581 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10052240 -- 53,951,160(+) ttata(A/T)attgt intron-variant, downstream-variant-500B
rs112726158 -- 53,952,106(+) AAAAT(-/A)AAAAA intron-variant, upstream-variant-2KB
rs115096624 -- 53,951,398(+) GGATG(C/T)TGCAG intron-variant, downstream-variant-500B
rs115736417 -- 53,953,528(+) TATTA(C/T)GCAAA intron-variant, upstream-variant-2KB
rs12514705 -- 53,951,882(+) TTTTG(G/T)GCTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR581 Gene

Variant ID Type Subtype PubMed ID
nsv830299 CNV gain 17160897
dgv5666n100 CNV gain 25217958

Relevant External Links for MIR581 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR581

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR581 Gene

Disorders for MIR581 Gene

Relevant External Links for MIR581

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR581

No disorders were found for MIR581 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR581 Gene

Publications for MIR581 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. MicroRNA-581 promotes hepatitis B virus surface antigen expression by targeting Dicer and EDEM1. (PMID: 24913918) Wang Y.Q. … Tang K.F. (Carcinogenesis 2014) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR581 Gene

Sources for MIR581 Gene

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