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Aliasesfor MIR581 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
10 fRNAdb ,
12 H-InvDB ,
13 NCBI ,
14 NONCODE ,
and/or 15 RNAdb )About This Section GeneCards Plus Subcategory (RNA class): miRNAQuality score for this RNA gene is 8 Aliases MicroRNA 581 1 2 MIRN5811 2 hsa-mir-5812 mir-5819
External Ids: HGNC: 32837 1 Entrez Gene: 693166 2 Ensembl: ENSG00000207627 7 Export aliases for MIR581 gene to outside databases
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Summariesfor MIR581 gene (According to Entrez Gene ,
GeneCards ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section GeneCards Plus Entrez Gene summary for MIR581 Gene: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation ofgene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs aretranscribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that canbe either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzymeto produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by thecytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. Themature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs throughimperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization ofthe target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009) GeneCards Summary for MIR581 Gene: MIR581 (microRNA 581) is an RNA gene, and is affiliated with the miRNA class. fRNAdb sequence ontology for MIR581: pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.View fRNAdb secondary structures for MIR581
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Genomic Viewsfor MIR581 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 75) ,
Regulatory elements and Epigenetics data according to
QIAGEN , and/or
SwitchGear Genomics )About This Section GeneCards Plus Regulatory elements: Search for regulatory transcription factor binding sites for MIR581 Other transcription factors Search Chromatin IP Primers for MIR581 Epigenetics: DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR581
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5q11.2 Ensembl cytogenetic band: 5q11.2 HGNC cytogenetic band: 5q11.2 MIR581 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M053284: view genomic region miRBase )
(about GC identifiers )
Start: 53,247,334 bp from pter End:
53,247,429 bp from pter
Size: 96 bases Orientation:
minus strand
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Proteinsfor MIR581 gene
(According to
1 UniProtKB ,
HORDE ,
2 neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to PhosphoSitePlus ,
Specific Peptides from DME ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Cloud-Clone Corp. ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Cloud-Clone Corp. ,
Antibodies by
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
LSBio ,
Abcam , and/or
Cloud-Clone Corp. )
About This Section GeneCards Plus UniProtKB: --
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Domains /for MIR581 gene (According to HGNC , IUPHAR , InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section GeneCards Plus HGNC Gene Families: MIR: ncRNAs / Micro RNAs
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Functionfor MIR581 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
genOway ,
QIAGEN
and/or HOMER ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
Gene Editing from DNA2.0 ,
Clones from OriGene ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
ESI BIO ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus Animal Models: Cell Line GenScript Custom overexpressing Cell Line Services for MIR581 Browse ESI BIO Cell Lines and PureStem Progenitors for MIR581 In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581
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Localizationfor MIR581 gene
(According to UniProtKB , COMPARTMENTS Subcellular localization database ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene .)
About This Section GeneCards Plus
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Pathways & Interactionsfor MIR581 gene
(SuperPaths according to PathCards ,
Pathways according to
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Sino Biological ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
QIAGEN ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene) .
About This Section GeneCards Plus Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR581 Interactions: Search GeneGlobe Interaction Network for MIR581
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Drugs & Compoundsfor MIR581 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience ,
ApexBio ,
HMDB ,
BitterDB , and/or
Novoseek ,
Ligands according to IUPHAR ,
and Drugs according to DrugBank ,
Enzo Life Sciences , and/or
PharmGKB )
About This Section GeneCards Plus Browse compounds at ApexBio Browse Tocris compounds for MIR581
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Transcriptsfor MIR581 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , KenesGroup ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
SwitchGear Genomics ,
OriGene ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene , and/or
QIAGEN
)About This Section GeneCards Plus 1 fRNAdb Secondary structure: 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000384895(miRNA) GeneLoc Exon Structure
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Expression for MIR581 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
Protein expression images according to data from SPIRE 1 MOPED ,
2 PaxDb , and 3 MaxQB ,
plus additional links to
SOURCE , and/or
BioGPS , and/or
UniProtKB ,QIAGEN ,
Primers from
OriGene , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section GeneCards Plus Expression evidence for MIR581:miRBase See probesets specificity/sensitivity at GeneAnnot CGAP TAG: --
MIR581 Protein expression data from MOPED1 2 3 : Custom PCR Arrays for MIR581 Primer Browse OriGene qPCR Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR581 Search QuantiTect SYBR Green Assays in human, mouse, rat MIR581 Search QuantiFast Probe-based Assays in human, mouse, rat MIR581 In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581
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Orthologsfor MIR581 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section GeneCards Plus Orthologs for MIR581 gene from 1 species (see representative species ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chimpanzee Mammalia ptr-mir-5816
ptr-mir-581
99(a)
1 ↔ 1
5(61561041-61561135)
ENSEMBL Gene Tree for MIR581 (if available)TreeFam Gene Tree for MIR581 (if available)
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Paralogsfor MIR581 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section GeneCards Plus
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Genomic Variantsfor MIR581 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
4 UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) , the Human Cytochrome P450 Allele
Nomenclature Database , and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN )
About This Section GeneCards Plus Structural Variations Database of Genomic Variants (DGV) 3 variations for MIR581 : About this table Site Specific Mutation Identification with PCR Assays
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Disorders
/ Diseasesfor MIR581 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Conferences by KenesGroup ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section GeneCards Plus
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Publicationsfor MIR581 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section GeneCards Plus PubMed articles for MIR581 gene integrated from 10 sources :(articles sorted by number of sources associating them with MIR581) Utopia : connect your pdf to the dynamic
miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832) 1 (Nucleic Acids Res. 2006) The colorectal microRNAome. (PubMed id 16505370) 1 (Proc. Natl. Acad. Sci. U.S.A. 2006)
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External Searches for MIR581 gene (in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section GeneCards Plus
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Genome Databases showing MIR581 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section GeneCards Plus
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Other Databases showing MIR581 gene
(According to HUGE )
About This Section GeneCards Plus --
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Specialized Databases showing MIR581 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , UniProtKB/TrEMBL , and/or others, e.g. Wikipedia and GeneReviews , via UniProtKB/Swiss-Prot )About This Section GeneCards Plus
Name Description PharmGKB entry for MIR581 Pharmacogenomics, SNPs, Pathways
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About This Section GeneCards Plus Patent Information for MIR581 gene: MIR581 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MIR581 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Cloud-Clone Corp. , Thermo Fisher Scientific , LSBio , Gene Editing from DNA2.0 . Clones from OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , and ESI BIO , PCR Arrays from QIAGEN , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , Enzo Life Sciences , and/or
ApexBio , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory ,
genOway )About This Section GeneCards Plus
Block miRNA regulation of human, mouse, rat MIR581 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MIR581 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR581 Predesigned siRNA for gene silencing in human mouse rat Search QuantiFast Probe-based Assays in human, mouse, rat MIR581 Search QuantiTect SYBR Green Assays in human, mouse, rat MIR581 Custom PCR Arrays for MIR581 Search Chromatin IP Primers for MIR581 Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR581 Search GeneGlobe Interaction Network for MIR581 Search Regulatory tfbs for MIR581
Search Tocris compounds for MIR581
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581
Search ThermoFisher Antibodies for MIR581
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR581
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