Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR581 Gene

RNA gene   GIFtS: 18
GCID: GC05M053284

MicroRNA 581


(Previous symbol: MIRN581)
  Search for MIR581
at
MalaCards
 

Aliases
for MIR581 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Subcategory (RNA class): miRNA

Quality score for this RNA gene is 8

Aliases
MicroRNA 5811 2
MIRN5811 2
hsa-mir-5812
mir-5819

External Ids:    HGNC: 328371   Entrez Gene: 6931662   Ensembl: ENSG000002076277   
ORGUL members:    fRNAdb10:FR006888 FR006888 FR021762      
miRBase:MI0003588 MIMAT0003246    

Export aliases for MIR581 gene to outside databases


Summaries
for MIR581 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR581 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR581 Gene: 
MIR581 (microRNA 581) is an RNA gene, and is affiliated with the miRNA class.



fRNAdb sequence ontology for MIR581:
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR581

Genomic Views
for MIR581 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR581
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIR581

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR581


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5q11.2

MIR581 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR581 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M053284:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 53,247,334 bp from pter      End:
 53,247,429 bp from pter
Size:
 96 bases      Orientation:
 minus strand

Proteins
for MIR581 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR581 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
 HGNC Gene Families: 
MIR: ncRNAs / Micro RNAs

  --

Function
for MIR581 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section
Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for MIR581 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIR581

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MIR581 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MIR581 

miRNA
Products:    		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR581
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR581
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:    		Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR581

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for MIR581

Clone
Products:     		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MIR581
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIR581
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR581

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for MIR581
Search LifeMap BioReagents cell lines for MIR581
In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581


Pathways & Interactions
for MIR581 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR581

Drugs & Compounds
for MIR581 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR581

Search CenterWatch for drugs/clinical trials and news about MIR581

Transcripts
for MIR581 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 1 fRNAdb Secondary structure:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000384895(miRNA)
miRNA
Products:     		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MIR581
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate MIR581
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
Browse OriGene RNAi
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR581
Clone
Products:     		Browse OriGene untagged/tagged cDNA clones in CMV expression vector
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for MIR581
DNA2.0 Custom Codon Optimized Gene Synthesis Service for MIR581
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR581
Primer
Products:    		Browse OriGene qPCR
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MIR581
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR581
  Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR581

GeneLoc Exon Structure


Expression
for MIR581 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR581:miRBase

MIR581 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR581 Expression
About this image

    SABiosciences Custom PCR Arrays for MIR581
Primer
Products:		Browse OriGene qPCR
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat MIR581
Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR581
Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR581
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581

Orthologs
for MIR581 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and chimp.

Orthologs for MIR581 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chimpanzee
(Pan troglodytes)		 Mammalia --
 --
 99(a)
 1 ↔ 1
 5(61561041-61561135) ENSPTRG00000028090


ENSEMBL Gene Tree for MIR581 (if available)
TreeFam Gene Tree for MIR581 (if available)

Paralogs
for MIR581 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for MIR581 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
Structural Variations
     Database of Genomic Variants (DGV) 3 variations for MIR581:    About this table     
Variant IDTypeSubtypePubMed ID
nsv880713CNV Gain21882294
nsv830299CNV Gain17160897
nsv880272CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR581
DNA2.0 Custom Variant and Variant Library Synthesis for MIR581

Disorders / Diseases
for MIR581 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for MIR581 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR581 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR581)		    Utopia: connect your pdf to the dynamic
world of online information

  1. miRBase: microRNA sequences, targets and gene nomencl ature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (2006)
  2. The colorectal microRNAome. (PubMed id 16505370)1 Cummins J.M....Velculescu V.E. (2006)

External Searches for MIR581 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR581 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 693166 HGNC: 32837 Ensembl:ENSG00000207627 miRBase: hsa-mir-581 euGenes: HUgn693166
ECgene: MIR581 H-InvDB: MIR581

Other Databases showing MIR581 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR581 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR581 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR581 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR581 gene:
Search GeneIP for patents involving MIR581

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR581 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   Browse OriGene RNAi products  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   Browse OriGene clones  
 Browse OriGene qSTAR qPCR primer pairs   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for MIR581   OriGene Custom Protein Services for MIR581  

 		 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR581
 QIAGEN SeqTarget long-range PCR primers for resequencing MIR581
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR581
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR581
 Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR581
 Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR581
 GenScript Custom Purified and Recombinant Proteins Services for MIR581 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MIR581
 GenScript Custom Assay Services for MIR581 GenScript Custom Superior Antibodies Services for MIR581
 GenScript Custom overexpressing Cell Line Services for MIR581 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Search Regulatory tfbs for MIR581
 Search Chromatin IP Primers for MIR581
 Search RT2 qPCR Primer Assays in human, mouse, rat MIR581
 Search GNC Networks for MIR581
 SABiosciences Custom PCR Arrays for MIR581
 Search Tocris compounds for MIR581
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Biologicals
 Novus Tissue Slides
 Search for Antibodies for MIR581 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for MIR581
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for MIR581
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR581
 Browse SwitchGear 3'UTR luciferase reporter plasmids for MIR581
 Browse SwitchGear Promoter luciferase reporter plasmids for MIR581
 Search ThermoFisher Antibodies for MIR581
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR581
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MIR581
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIR581
Customized:
 lentivirus for stable overexpression
 lentivirus expression plasmids for stable overexpression
 adenovirus for overexpression
 Search LSBio for Antibodies for MIR581
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
Hot genes      Disease genes      MIR581 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4