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MIR579 Gene(RNA Gene)

MicroRNA 579

GCID:
GC05M032431
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR579 Gene

Subcategory (RNA class) for MIR579 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR579 Gene

  • MicroRNA 579 2 3 5
  • Hsa-Mir-579 3
  • MIRN579 3

External Ids for MIR579 Gene

ORGUL Members for MIR579 Gene

Previous HGNC Symbols for MIR579 Gene

  • MIRN579

Summaries for MIR579 Gene

Entrez Gene Summary for MIR579 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR579 Gene

MIR579 (MicroRNA 579) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR579 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR579

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR579 Gene

Genomics for MIR579 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR579 Gene

Enhancers for MIR579 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G032329 1.5 Ensembl ENCODE dbSUPER 11.2 +63.6 63572 3.2 FOXA2 ATF1 ARID4B DMAP1 ZNF143 DEK SP5 REST PPARG KAT8 MTMR12 MIR579 ZFR GOLPH3 LOC646616 SUB1 GC05P032360
GH05G032230 1.5 Ensembl ENCODE dbSUPER 11.2 +161.6 161562 5.3 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF2 ZNF48 YY1 SLC30A9 ZNF121 GOLPH3 MIR579 ZFR MTMR12 GC05M032236 RNU6-1079P GC05P032221
GH05G032442 1.4 FANTOM5 ENCODE 10.5 -50.5 -50461 5.0 HDGF HNRNPUL1 PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 YY1 MTMR12 ENSG00000249572 MIR579 ZFR LOC646616
GH05G032297 1.3 Ensembl ENCODE dbSUPER 10.8 +96.3 96317 0.9 PKNOX1 TBL1XR1 TCF12 EGR1 EGR2 ZNF592 CREB3 MBD2 NFIC MAFF GOLPH3 MIR579 ZFR MTMR12 GC05P032310 GC05M032181
GH05G032489 1.2 Ensembl ENCODE 11.2 -95.7 -95748 1.7 FOXA2 SIN3A ARID4B FEZF1 ZNF2 ZNF48 ZNF121 ZNF143 DEK REST LOC646616 SUB1 ZFR MIR579
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR579 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR579 Gene

Chromosome:
5
Start:
32,394,378 bp from pter
End:
32,394,475 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR579 Gene

Genes around MIR579 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR579 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR579 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR579 Gene

ORGUL Member Location for MIR579 Gene

ORGUL Member Location for MIR579 gene

Proteins for MIR579 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR579 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR579 Gene

Domains & Families for MIR579 Gene

Gene Families for MIR579 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR579: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR579 Gene

Function for MIR579 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR579 Gene

Localization for MIR579 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR579 Gene

Pathways & Interactions for MIR579 Gene

SuperPathways for MIR579 Gene

PathCards logo More details on SuperPathways for MIR579
No Data Available

Interacting Proteins for MIR579 Gene

Gene Ontology (GO) - Biological Process for MIR579 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR579 Gene

Drugs & Compounds for MIR579 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR579 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR579 Gene

  • hsa-mir-579_MI0003586_Homo_sapiens_miR-579_stem-loop_hairpin

mRNA/cDNA for MIR579 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR579 Gene

No ASD Table

Relevant External Links for MIR579 Gene

GeneLoc Exon Structure for
MIR579
ECgene alternative splicing isoforms for
MIR579

Expression for MIR579 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR579 Gene

mRNA expression in normal human tissues for MIR579 Gene
mRNA expression by GTEx for MIR579 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR579 Gene:

MIR579
genes like me logo Genes that share expression patterns with MIR579: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR579 Gene

Orthologs for MIR579 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR579 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-579 35
  • 100 (a)
 OneToOne
Species where no ortholog for MIR579 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR579 Gene

ENSEMBL:
Gene Tree for MIR579 (if available)
TreeFam:
Gene Tree for MIR579 (if available)

Paralogs for MIR579 Gene

No data available for Paralogs for MIR579 Gene

Variants for MIR579 Gene

Sequence variations from dbSNP and Humsavar for MIR579 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1001381536 -- 32,395,894(+) TATGT(C/T)ATCAG intron-variant, upstream-variant-2KB
rs1001744326 -- 32,395,676(+) ACCAA(A/C)CCCTC intron-variant, upstream-variant-2KB
rs1003686536 -- 32,394,296(+) AATAC(A/T)GAAAC intron-variant, downstream-variant-500B
rs1003840614 -- 32,394,173(+) GCAAT(A/G)CTCAT intron-variant, downstream-variant-500B
rs1004341726 -- 32,395,494(+) TATGT(A/G)AAAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR579 Gene

Variant ID Type Subtype PubMed ID
esv2730031 CNV deletion 23290073
esv2759338 CNV loss 17122850
nsv1021781 CNV gain 25217958

Relevant External Links for MIR579 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR579

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR579 Gene

Disorders for MIR579 Gene

Relevant External Links for MIR579

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR579

No disorders were found for MIR579 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR579 Gene

Publications for MIR579 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR. (PMID: 25799583) Hinske L.C. … Kreth S. (PLoS ONE 2015) 3 64
  3. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  4. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-I+ during TLR4-induced gene reprogramming. (PMID: 21562054) El Gazzar M. … McCall C.E. (J. Leukoc. Biol. 2011) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR579 Gene

Sources for MIR579 Gene

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