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Aliases for MIR577 Gene

Subcategory (RNA class) for MIR577 Gene


Quality Score for this RNA gene is


Aliases for MIR577 Gene

  • MicroRNA 577 2 3 5
  • Hsa-Mir-577 3
  • Mir-577 3
  • MIRN577 3

External Ids for MIR577 Gene

ORGUL Members for MIR577 Gene

Previous HGNC Symbols for MIR577 Gene

  • MIRN577

Previous GeneCards Identifiers for MIR577 Gene

  • GC04P115798
  • GC04P115577

Summaries for MIR577 Gene

Entrez Gene Summary for MIR577 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR577 Gene

MIR577 (MicroRNA 577) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR577 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR577 Gene

Genomics for MIR577 Gene

GeneHancer (GH) Regulatory Elements for MIR577 Gene

Promoters and enhancers for MIR577 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I114649 Enhancer 0.6 dbSUPER 550.8 +0.1 120 14.1 SCRT1 CTCF ZNF654 TEAD1 TRIM22 IRF4 RAD21 ZNF664 SCRT2 MBD1 GC04P114657 GC04P114658 MIR577 UGT8 GC04P114633 GC04M114714
GH04I114597 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.8 -55.7 -55666 6.7 PKNOX1 SIN3A FEZF1 ZNF2 IRF4 GLIS2 ATF7 RUNX3 KLF13 SP3 UGT8 MIR577 GC04P114629
GH04I114606 Enhancer 0.5 ENCODE dbSUPER 10.8 -50.1 -50128 1 SP1 MIR577 UGT8 GC04P114629
GH04I114683 Enhancer 0.3 dbSUPER 11.2 +27.3 27333 2.2 ZNF585B MIR577 UGT8 GC04P114657 GC04M114714
GH04I114561 Enhancer 0.3 ENCODE 11.1 -93.1 -93105 4.6 ZIC2 UGT8 MIR577 LOC105377380
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR577 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR577 Gene

Genomic Locations for MIR577 Gene
96 bases
Plus strand

Genomic View for MIR577 Gene

Genes around MIR577 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR577 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR577 Gene

Proteins for MIR577 Gene

Post-translational modifications for MIR577 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR577 Gene

Domains & Families for MIR577 Gene

Gene Families for MIR577 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR577: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR577 Gene

Function for MIR577 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR577 Gene

Localization for MIR577 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR577 Gene

Pathways & Interactions for MIR577 Gene

SuperPathways for MIR577 Gene

No Data Available

Interacting Proteins for MIR577 Gene

Gene Ontology (GO) - Biological Process for MIR577 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR577 Gene

Drugs & Compounds for MIR577 Gene

No Compound Related Data Available

Transcripts for MIR577 Gene

mRNA/cDNA for MIR577 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR577 Gene

No ASD Table

Relevant External Links for MIR577 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR577 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR577 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR577 Gene:

genes like me logo Genes that share expression patterns with MIR577: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR577 Gene

Orthologs for MIR577 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR577 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-577 34
  • 100 (a)
Species where no ortholog for MIR577 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR577 Gene

Gene Tree for MIR577 (if available)
Gene Tree for MIR577 (if available)

Paralogs for MIR577 Gene

No data available for Paralogs for MIR577 Gene

Variants for MIR577 Gene

Sequence variations from dbSNP and Humsavar for MIR577 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000339867 -- 114,655,185(+) T/C upstream_transcript_variant
rs10011293 -- 114,656,225(+) C/T upstream_transcript_variant
rs1001612825 -- 114,656,726(+) G/C upstream_transcript_variant
rs1002624245 -- 114,655,374(+) G/C upstream_transcript_variant
rs1005969851 -- 114,655,909(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR577 Gene

Variant ID Type Subtype PubMed ID
esv2752021 CNV gain 17911159
esv2759275 CNV loss 17122850
esv3601829 CNV gain 21293372
esv3601835 CNV gain 21293372
nsv524515 CNV gain 19592680
nsv830039 CNV gain 17160897

Additional Variant Information for MIR577 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR577 Gene

Disorders for MIR577 Gene

Additional Disease Information for MIR577

No disorders were found for MIR577 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR577 Gene

Publications for MIR577 Gene

  1. Up-regulated lnc-SNHG1 contributes to osteosarcoma progression through sequestration of miR-577 and activation of WNT2B/Wnt/β-catenin pathway. (PMID: 29108989) Jiang Z … Fang J (Biochemical and biophysical research communications 2018) 3 58
  2. microRNA-577 suppresses tumor growth and enhances chemosensitivity in colorectal cancer. (PMID: 28150434) Jiang H … Jie K (Journal of biochemical and molecular toxicology 2017) 3 58
  3. miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. (PMID: 25764520) Zhang W … Zhao S (Molecular carcinogenesis 2016) 3 58
  4. Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma. (PMID: 24294352) Yuan X … Gu J (International journal of clinical and experimental pathology 2013) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR577 Gene

Sources for MIR577 Gene

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