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Aliases for MIR577 Gene

Subcategory (RNA class) for MIR577 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR577 Gene

  • MicroRNA 577 2 3 5
  • Hsa-Mir-577 3
  • Mir-577 3
  • MIRN577 3

External Ids for MIR577 Gene

ORGUL Members for MIR577 Gene

Previous HGNC Symbols for MIR577 Gene

  • MIRN577

Previous GeneCards Identifiers for MIR577 Gene

  • GC04P115798
  • GC04P115577

Summaries for MIR577 Gene

Entrez Gene Summary for MIR577 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR577 Gene

MIR577 (MicroRNA 577) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR577 Gene

Genomics for MIR577 Gene

Regulatory Elements for MIR577 Gene

Enhancers for MIR577 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F114597 1.2 Ensembl ENCODE 10.8 -55.7 -55666 6.7 PKNOX1 FEZF1 ZNF2 GLIS2 CBX5 SP3 JUNB TBX21 GLIS1 NBN UGT8 MIR577 GC04P114629
GH04F114561 0.6 Ensembl ENCODE 11.1 -93.1 -93105 4.6 ZIC2 UGT8 MIR577 LOC105377380
GH04F114606 0.4 ENCODE 10.8 -50.1 -50128 1.0 KDM1A MIR577 UGT8 GC04P114629
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR577 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR577 Gene

Chromosome:
4
Start:
114,656,759 bp from pter
End:
114,656,854 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR577 Gene

Genes around MIR577 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR577 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR577 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR577 Gene

Proteins for MIR577 Gene

Post-translational modifications for MIR577 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR577 Gene

Domains & Families for MIR577 Gene

Gene Families for MIR577 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR577: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR577 Gene

Function for MIR577 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR577 Gene

Localization for MIR577 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR577 Gene

Pathways & Interactions for MIR577 Gene

SuperPathways for MIR577 Gene

No Data Available

Interacting Proteins for MIR577 Gene

Gene Ontology (GO) - Biological Process for MIR577 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR577 Gene

Transcripts for MIR577 Gene

mRNA/cDNA for MIR577 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR577 Gene

No ASD Table

Relevant External Links for MIR577 Gene

GeneLoc Exon Structure for
MIR577
ECgene alternative splicing isoforms for
MIR577

Expression for MIR577 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR577 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR577 Gene:

MIR577
genes like me logo Genes that share expression patterns with MIR577: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR577 Gene

Orthologs for MIR577 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR577 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-577 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR577 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR577 Gene

ENSEMBL:
Gene Tree for MIR577 (if available)
TreeFam:
Gene Tree for MIR577 (if available)

Paralogs for MIR577 Gene

No data available for Paralogs for MIR577 Gene

Variants for MIR577 Gene

Sequence variations from dbSNP and Humsavar for MIR577 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10011293 -- 114,656,225(+) agtct(C/T)tGTGT intron-variant, upstream-variant-2KB
rs112206926 -- 114,656,857(+) TACTG(G/T)AGGTA intron-variant, downstream-variant-500B
rs114746505 -- 114,655,205(+) GCATC(A/G)TCCAG intron-variant, upstream-variant-2KB
rs118070498 -- 114,655,828(+) TAATA(A/G)GGAAA intron-variant, upstream-variant-2KB
rs138018978 -- 114,655,186(+) ACTTT(C/T)ATTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR577 Gene

Variant ID Type Subtype PubMed ID
nsv830039 CNV gain 17160897
nsv524515 CNV gain 19592680
esv3601835 CNV gain 21293372
esv3601829 CNV gain 21293372
esv2759275 CNV loss 17122850
esv2752021 CNV gain 17911159

Relevant External Links for MIR577 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR577

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR577 Gene

Disorders for MIR577 Gene

Relevant External Links for MIR577

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR577

No disorders were found for MIR577 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR577 Gene

Publications for MIR577 Gene

  1. miR-577 inhibits glioblastoma tumor growth via the Wnt signaling pathway. (PMID: 25764520) Zhang W. … Zhao S. (Mol. Carcinog. 2016) 3 64
  2. Effects and interactions of MiR-577 and TSGA10 in regulating esophageal squamous cell carcinoma. (PMID: 24294352) Yuan X. … Gu J. (Int J Clin Exp Pathol 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR577 Gene

Sources for MIR577 Gene

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