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Aliases for MIR575 Gene

Subcategory (RNA class) for MIR575 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR575 Gene

  • MicroRNA 575 2 3 5
  • Hsa-Mir-575 3
  • MIRN575 3

External Ids for MIR575 Gene

Previous HGNC Symbols for MIR575 Gene

  • MIRN575

Previous GeneCards Identifiers for MIR575 Gene

  • GC04M083896
  • GC04M083674

Summaries for MIR575 Gene

Entrez Gene Summary for MIR575 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR575 Gene

MIR575 (MicroRNA 575) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR575 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR575 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR575 Gene

Genomics for MIR575 Gene

Regulatory Elements for MIR575 Gene

Enhancers for MIR575 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H082715 1.1 Ensembl ENCODE dbSUPER 11.2 +37.2 37213 1 SOX13 SCRT1 NFIL3 GATA3 SCRT2 CREB1 BCL6 TMEM150C MIR575 PIR47609
GH04H082811 1.1 ENCODE dbSUPER 10.9 -58.7 -58693 0 PKNOX1 FOXA2 INSM2 FEZF1 ZIC2 ZNF2 ZBTB40 RAD21 ZNF121 FOXK2 MIR575 THAP9 SCD5 GC04M082828
GH04H082710 0.9 ENCODE dbSUPER 11.4 +43.0 43001 0 SOX5 SOX13 GATAD2A TFAP4 SP5 ZNF398 SREBF1 TCF7 NR2F6 KDM1A MIR575 TMEM150C PIR47609
GH04H082812 0.9 ENCODE dbSUPER 10.9 -59.1 -59053 0 FOXA2 MAZ FEZF1 ZEB2 REST ZNF2 NR2F2 PRDM6 FOXK2 ZNF629 MIR575 SCD5 GC04M082828
GH04H082686 0.6 ENCODE dbSUPER 11.8 +65.6 65647 1 NR2F1 MIR575 PQLC1P2 TMEM150C GPAT3 LINC00575
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR575 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR575 Gene

Chromosome:
4
Start:
82,753,337 bp from pter
End:
82,753,430 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR575 Gene

Genes around MIR575 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR575 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR575 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR575 Gene

ORGUL Member Location for MIR575 Gene

ORGUL Member Location for MIR575 gene

Proteins for MIR575 Gene

Post-translational modifications for MIR575 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR575 Gene

Domains & Families for MIR575 Gene

Gene Families for MIR575 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR575: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR575 Gene

Function for MIR575 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR575
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR575 Gene

Localization for MIR575 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR575 Gene

Pathways & Interactions for MIR575 Gene

SuperPathways for MIR575 Gene

No Data Available

Interacting Proteins for MIR575 Gene

Gene Ontology (GO) - Biological Process for MIR575 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR575 Gene

Drugs & Compounds for MIR575 Gene

No Compound Related Data Available

Transcripts for MIR575 Gene

mRNA/cDNA for MIR575 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR575
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR575 Gene

No ASD Table

Relevant External Links for MIR575 Gene

GeneLoc Exon Structure for
MIR575
ECgene alternative splicing isoforms for
MIR575

Expression for MIR575 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR575 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR575 Gene:

MIR575
genes like me logo Genes that share expression patterns with MIR575: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR575 Gene

Orthologs for MIR575 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR575 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-575 34
  • 100 (a)
OneToOne
Species where no ortholog for MIR575 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR575 Gene

ENSEMBL:
Gene Tree for MIR575 (if available)
TreeFam:
Gene Tree for MIR575 (if available)

Paralogs for MIR575 Gene

No data available for Paralogs for MIR575 Gene

Variants for MIR575 Gene

Sequence variations from dbSNP and Humsavar for MIR575 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000110758 -- 82,754,227(+) GAAAG(A/G)AGAAG intron-variant, upstream-variant-2KB
rs1000559561 -- 82,752,907(+) AAAGG(G/T)AGGTC intron-variant, downstream-variant-500B
rs1000893152 -- 82,753,679(+) TTTCT(C/G)CTTGA intron-variant, upstream-variant-2KB
rs1001338735 -- 82,754,740(+) GCTGG(A/G)AAGTG intron-variant, upstream-variant-2KB
rs1002184803 -- 82,753,187(+) AGGGA(A/G)CATGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR575 Gene

Variant ID Type Subtype PubMed ID
nsv1006474 CNV gain 25217958
nsv594744 CNV gain 21841781

Relevant External Links for MIR575 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR575

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR575 Gene

Disorders for MIR575 Gene

Relevant External Links for MIR575

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR575

No disorders were found for MIR575 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR575 Gene

Publications for MIR575 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 60
  2. MicroRNA-575 targets BLID to promote growth and invasion of non-small cell lung cancer cells. (PMID: 25728273) Wang H … Shao Y (FEBS letters 2015) 3 60
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR575 Gene

Sources for MIR575 Gene

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