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Aliases for MIR574 Gene

Subcategory (RNA class) for MIR574 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR574 Gene

  • MicroRNA 574 2 3 5
  • Hsa-Mir-574 3
  • MIR574-3p 3
  • Mir-574 3
  • MIRN574 3

External Ids for MIR574 Gene

ORGUL Members for MIR574 Gene

Previous HGNC Symbols for MIR574 Gene

  • MIRN574

Previous GeneCards Identifiers for MIR574 Gene

  • GC04U900958
  • GC04P038554
  • GC04P038869

Summaries for MIR574 Gene

Entrez Gene Summary for MIR574 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR574 Gene

MIR574 (MicroRNA 574) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR574 Gene

Genomics for MIR574 Gene

Regulatory Elements for MIR574 Gene

Enhancers for MIR574 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G038071 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -793.7 -793717 6.2 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SP5 JUNB MIR574 FAM114A1 TLR1 TLR6 MRPS33P2 GC04P038183 GC04P038184 GC04P038187 GC04P038188 PIR31939
GH04G038077 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -785.3 -785285 10.1 PKNOX1 FOXA2 ZFP64 ARID4B ZNF48 ETS1 GATA2 FOS SP5 ZHX2 FAM114A1 TLR1 TLR6 MIR574 TBC1D1 MRPS33P2 GC04P038183 GC04P038184 GC04P038187 GC04P038188
GH04G038759 1.5 FANTOM5 Ensembl ENCODE 12.2 -106.1 -106100 5.1 HDGF TBP TBL1XR1 WRNIP1 BMI1 YBX1 RAD21 RELB ETV6 IKZF2 TLR1 TLR6 TLR10 MIR574 FAM114A1 KLF3 RNA5SP158
GH04G038785 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -81.9 -81901 2.1 ELF3 FOXA2 THRB YY1 RARA ZNF143 ETV6 CREM MIXL1 CBFB TLR1 TLR6 FAM114A1 MIR574 KLF3 TLR10
GH04G038188 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -678.2 -678177 3.5 FOXA2 ZFP64 SIN3A FEZF1 TCF12 ZNF766 FOS TSHZ1 ZNF518A SREBF1 FAM114A1 MIR574 TLR6 TLR1 GC04P038183 GC04P038187 PIR31939 GC04P038188 GC04P038184 LOC105374408
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR574 on UCSC Golden Path with GeneCards custom track

Promoters for MIR574 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167563 868 201 ZNF623 THRB NR2F2

Genomic Location for MIR574 Gene

Chromosome:
4
Start:
38,868,032 bp from pter
End:
38,868,127 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR574 Gene

Genes around MIR574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR574 Gene

Proteins for MIR574 Gene

Post-translational modifications for MIR574 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR574 Gene

Domains & Families for MIR574 Gene

Gene Families for MIR574 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR574: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR574 Gene

Function for MIR574 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR574 Gene

Localization for MIR574 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR574 Gene

Pathways & Interactions for MIR574 Gene

SuperPathways for MIR574 Gene

No Data Available

Interacting Proteins for MIR574 Gene

Gene Ontology (GO) - Biological Process for MIR574 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR574 Gene

Transcripts for MIR574 Gene

mRNA/cDNA for MIR574 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR574 Gene

No ASD Table

Relevant External Links for MIR574 Gene

GeneLoc Exon Structure for
MIR574
ECgene alternative splicing isoforms for
MIR574

Expression for MIR574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR574 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR574 Gene:

MIR574
genes like me logo Genes that share expression patterns with MIR574: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR574 Gene

Orthologs for MIR574 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR574 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-574 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir574 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU459159.1 35
  • 51 (a)
ManyToMany
Species where no ortholog for MIR574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR574 Gene

ENSEMBL:
Gene Tree for MIR574 (if available)
TreeFam:
Gene Tree for MIR574 (if available)

Paralogs for MIR574 Gene

No data available for Paralogs for MIR574 Gene

Variants for MIR574 Gene

Sequence variations from dbSNP and Humsavar for MIR574 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1001833236 -- 38,868,279(+) CACGA(A/G)GGGAG intron-variant, downstream-variant-500B
rs1002836600 -- 38,867,187(+) GGACA(C/T)TGAGA upstream-variant-2KB
rs1003668763 -- 38,868,607(+) AGTAG(C/G)AAGAC intron-variant, downstream-variant-500B
rs1005010254 -- 38,867,227(+) CTACA(A/G)CAAAC upstream-variant-2KB
rs1008233184 -- 38,866,053(+) AGAAT(C/T)GCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR574 Gene

Variant ID Type Subtype PubMed ID
nsv594010 CNV loss 21841781

Relevant External Links for MIR574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR574

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR574 Gene

Disorders for MIR574 Gene

Relevant External Links for MIR574

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR574

No disorders were found for MIR574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR574 Gene

Publications for MIR574 Gene

  1. Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-I^1. (PMID: 28042090) Zhang R. … Yang Q. (Gene 2017) 3 64
  2. Influence of continuous intervention on growth and metastasis of human cervical cancer cells and expression of RNAmiR-574-5p. (PMID: 27049079) Ma D.L. … Yan J. (J. Biol. Regul. Homeost. Agents 2016) 3 64
  3. The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma. (PMID: 27565418) Okumura T. … Shimada Y. (World J Surg Oncol 2016) 3 64
  4. Downregulation of microRNAa89574 in cancer stem cells causes recurrence of prostate cancer via targeting REL. (PMID: 27779701) Lai X. … Wang F. (Oncol. Rep. 2016) 3 64
  5. An optimized procedure for exosome isolation and analysis using serum samples: Application to cancer biomarker discovery. (PMID: 25814440) Li M. … Vlassov A.V. (Methods 2015) 3 64

Products for MIR574 Gene

Sources for MIR574 Gene

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