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Aliases for MIR574 Gene

Subcategory (RNA class) for MIR574 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR574 Gene

  • MicroRNA 574 2 3 5
  • Hsa-Mir-574 3
  • MIR574-3p 3
  • Mir-574 3
  • MIRN574 3

External Ids for MIR574 Gene

ORGUL Members for MIR574 Gene

Previous HGNC Symbols for MIR574 Gene

  • MIRN574

Previous GeneCards Identifiers for MIR574 Gene

  • GC04U900958
  • GC04P038554
  • GC04P038869

Summaries for MIR574 Gene

Entrez Gene Summary for MIR574 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR574 Gene

MIR574 (MicroRNA 574) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR574 Gene

Genomics for MIR574 Gene

Regulatory Elements for MIR574 Gene

Enhancers for MIR574 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F038759 1 FANTOM5 Ensembl ENCODE 12.2 -106.2 -106178 5.3 HDGF TBP TBL1XR1 WRNIP1 BMI1 YBX1 RAD21 ETV6 CREM ZNF654 TLR1 TLR6 TLR10 FAM114A1 MIR574 KLF3 RNA5SP158
GH04F038803 0.2 ENCODE 12 -62.7 -62721 3.3 TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 RAD21 ZBTB40 CBX5 ZNF143 ETV6 TLR1 TLR6 TLR10 MIR574 FAM114A1 LOC105374417 ENSG00000249685
GH04F038837 0.2 Ensembl 11.9 -29.8 -29832 0.8 JUND ATF3 ZBTB40 TLR6 FAM114A1 MIR574 TLR10 TLR1
GH04F038888 1.2 Ensembl ENCODE 11.3 +22.2 22242 3.3 PKNOX1 SAP130 JUN SIN3A BMI1 ZNF384 ZNF316 NFE2 FOS CREM TLR6 TLR1 MIR574 FAM114A1 GC04P038912
GH04F038779 0.8 Ensembl ENCODE 11.3 -86.7 -86704 3.5 HDGF TBP CTCF PKNOX1 WRNIP1 BMI1 EBF1 RAD21 YY1 POLR2A TLR1 TLR6 MIR574 FAM114A1 TLR10 RNA5SP158
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR574 on UCSC Golden Path with GeneCards custom track

Promoters for MIR574 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001239523 168 2001 CREB3L1 ARID4B DMAP1 ZNF48 ZBTB40 THRB RARA EGR2 SP5 ZNF623

Genomic Location for MIR574 Gene

Chromosome:
4
Start:
38,868,032 bp from pter
End:
38,868,127 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR574 Gene

Genes around MIR574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR574 Gene

Proteins for MIR574 Gene

Post-translational modifications for MIR574 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR574 Gene

Domains & Families for MIR574 Gene

Gene Families for MIR574 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR574: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR574 Gene

Function for MIR574 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR574 Gene

Localization for MIR574 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR574 Gene

Pathways & Interactions for MIR574 Gene

SuperPathways for MIR574 Gene

No Data Available

Interacting Proteins for MIR574 Gene

Gene Ontology (GO) - Biological Process for MIR574 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR574 Gene

Transcripts for MIR574 Gene

mRNA/cDNA for MIR574 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR574 Gene

No ASD Table

Relevant External Links for MIR574 Gene

GeneLoc Exon Structure for
MIR574
ECgene alternative splicing isoforms for
MIR574

Expression for MIR574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR574 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR574 Gene:

MIR574
genes like me logo Genes that share expression patterns with MIR574: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR574 Gene

Orthologs for MIR574 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR574 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-574 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir574 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 69 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU459159.1 35
  • 51 (a)
ManyToMany
Species where no ortholog for MIR574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR574 Gene

ENSEMBL:
Gene Tree for MIR574 (if available)
TreeFam:
Gene Tree for MIR574 (if available)

Paralogs for MIR574 Gene

No data available for Paralogs for MIR574 Gene

Variants for MIR574 Gene

Sequence variations from dbSNP and Humsavar for MIR574 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs111711885 -- 38,867,500(+) CACGG(C/T)GGGGG upstream-variant-2KB
rs115162100 -- 38,868,309(+) GGCCT(A/C)GTCCC intron-variant, downstream-variant-500B
rs115549597 -- 38,866,846(+) ACTAG(A/G)GCTAT upstream-variant-2KB
rs116290913 -- 38,866,691(+) ATAGG(A/G)GGAAA upstream-variant-2KB
rs139208981 -- 38,868,532(+) GCCCT(C/T)GCCTC intron-variant, downstream-variant-500B, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR574 Gene

Variant ID Type Subtype PubMed ID
nsv594010 CNV loss 21841781

Relevant External Links for MIR574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR574

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR574 Gene

Disorders for MIR574 Gene

Relevant External Links for MIR574

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR574

No disorders were found for MIR574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR574 Gene

Publications for MIR574 Gene

  1. Influence of continuous intervention on growth and metastasis of human cervical cancer cells and expression of RNAmiR-574-5p. (PMID: 27049079) Ma D.L. … Yan J. (J. Biol. Regul. Homeost. Agents 2016) 3 64
  2. An optimized procedure for exosome isolation and analysis using serum samples: Application to cancer biomarker discovery. (PMID: 25814440) Li M. … Vlassov A.V. (Methods 2015) 3 64
  3. Next generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer. (PMID: 26416693) Krishnan P. … Damaraju S. (BMC Genomics 2015) 3 64
  4. Tumor invasion and metastasis regulated by microRNA-184 and microRNA-574-5p in small-cell lung cancer. (PMID: 26587830) Zhou R. … Wu G. (Oncotarget 2015) 3 64
  5. miRNA 206 and miRNA 574-5p are highly expression in coronary artery disease. (PMID: 26685009) Zhou J. … Lian J. (Biosci. Rep. 2015) 3 64

Products for MIR574 Gene

Sources for MIR574 Gene

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