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Aliases for MIR574 Gene

Subcategory (RNA class) for MIR574 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR574 Gene

  • MicroRNA 574 2 3 5
  • Hsa-Mir-574 3
  • MIR574-3p 3
  • Mir-574 3
  • MIRN574 3

External Ids for MIR574 Gene

ORGUL Members for MIR574 Gene

Previous HGNC Symbols for MIR574 Gene

  • MIRN574

Previous GeneCards Identifiers for MIR574 Gene

  • GC04U900958
  • GC04P038554
  • GC04P038869

Summaries for MIR574 Gene

Entrez Gene Summary for MIR574 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR574 Gene

MIR574 (MicroRNA 574) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR574 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR574 Gene

Genomics for MIR574 Gene

GeneHancer (GH) Regulatory Elements for MIR574 Gene

Promoters and enhancers for MIR574 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I038866 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.9 918 4.1 SMAD1 RB1 ARID4B DMAP1 ZBTB40 THRB ZNF48 RARA YY1 ZNF335 FAM114A1 MIR574 GC04P038868 TLR6 GC04P038912
GH04I038803 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12 -62.7 -62732 3.4 PKNOX1 FOXA2 SMAD1 RB1 YBX1 ZBTB40 BATF KLF5 IRF4 RAD21 TLR1 TLR6 ZBTB12BP TLR10 FAM114A1 MIR574 ENSG00000249207 ENSG00000249685 HNRNPRP3 RFC1
GH04I038077 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -785.3 -785284 10.1 PKNOX1 FOXA2 ZFP64 ARID4B ZNF48 ETS1 ATF7 FOS RUNX3 RXRA FAM114A1 TLR1 TLR6 MIR574 TBC1D1 MRPS33P2 GC04P038184 GC04P038187 GC04P038188 PIR31939
GH04I038779 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 11.3 -86.6 -86645 3.6 HDGF PKNOX1 SMAD1 BMI1 IRF4 RAD21 ZNF143 ATF7 IKZF2 BCLAF1 TLR10 TLR1 TLR6 FAM114A1 MIR574 RNA5SP158
GH04I038071 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -793.7 -793717 6.2 PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 IRF4 ZNF48 ETS1 ATF7 RUNX3 TLR1 TLR6 FAM114A1 MIR574 MRPS33P2 GC04P038183 GC04P038184 GC04P038187 PIR31939 GC04P038188
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR574 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR574 Gene

Genomic Locations for MIR574 Gene
chr4:38,868,032-38,868,127
(GRCh38/hg38)
Size:
96 bases
Orientation:
Plus strand
chr4:38,869,653-38,869,748
(GRCh37/hg19)

Genomic View for MIR574 Gene

Genes around MIR574 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR574 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR574 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR574 Gene

Proteins for MIR574 Gene

Post-translational modifications for MIR574 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR574 Gene

Domains & Families for MIR574 Gene

Gene Families for MIR574 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR574: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR574 Gene

Function for MIR574 Gene

Phenotypes From GWAS Catalog for MIR574 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR574 Gene

Localization for MIR574 Gene

Gene Ontology (GO) - Cellular Components for MIR574 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR574: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR574 Gene

Pathways & Interactions for MIR574 Gene

SuperPathways for MIR574 Gene

No Data Available

Interacting Proteins for MIR574 Gene

Gene Ontology (GO) - Biological Process for MIR574 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR574 Gene

Drugs & Compounds for MIR574 Gene

No Compound Related Data Available

Transcripts for MIR574 Gene

mRNA/cDNA for MIR574 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR574 Gene

No ASD Table

Relevant External Links for MIR574 Gene

GeneLoc Exon Structure for
MIR574
ECgene alternative splicing isoforms for
MIR574

Expression for MIR574 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR574 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR574 Gene:

MIR574
genes like me logo Genes that share expression patterns with MIR574: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR574 Gene

Orthologs for MIR574 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR574 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-574 34
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir574 34
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU459159.1 34
  • 51 (a)
ManyToMany
Species where no ortholog for MIR574 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR574 Gene

ENSEMBL:
Gene Tree for MIR574 (if available)
TreeFam:
Gene Tree for MIR574 (if available)

Paralogs for MIR574 Gene

No data available for Paralogs for MIR574 Gene

Variants for MIR574 Gene

Sequence variations from dbSNP and Humsavar for MIR574 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1001833236 -- 38,868,279(+) A/G downstream_transcript_variant
rs1002836600 -- 38,867,187(+) T/C upstream_transcript_variant
rs1003668763 -- 38,868,607(+) G/C downstream_transcript_variant
rs1005010254 -- 38,867,227(+) A/G upstream_transcript_variant
rs1008233184 -- 38,866,053(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR574 Gene

Variant ID Type Subtype PubMed ID
nsv594010 CNV loss 21841781

Additional Variant Information for MIR574 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR574

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR574 Gene

Disorders for MIR574 Gene

Additional Disease Information for MIR574

No disorders were found for MIR574 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR574 Gene

Publications for MIR574 Gene

  1. Combining serum miRNAs, CEA, and CYFRA21-1 with imaging and clinical features to distinguish benign and malignant pulmonary nodules: a pilot study : Xianfeng Li et al.: Combining biomarker, imaging, and clinical features to distinguish pulmonary nodules. (PMID: 28545454) Li X … Cao L (World journal of surgical oncology 2017) 3 58
  2. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. (PMID: 28520992) Yao P … Fox PL (Nucleic acids research 2017) 3 58
  3. LncRNA PTCSC3/miR-574-5p Governs Cell Proliferation and Migration of Papillary Thyroid Carcinoma via Wnt/β-Catenin Signaling. (PMID: 28513866) Wang X … Shi Y (Journal of cellular biochemistry 2017) 3 58
  4. Upregulation of microRNA-574-3p in a human gastric cancer cell line AGS by TGF-β1. (PMID: 28042090) Zhang R … Yang Q (Gene 2017) 3 58
  5. Downregulation of microRNA‑574 in cancer stem cells causes recurrence of prostate cancer via targeting REL. (PMID: 27779701) Lai X … Wang F (Oncology reports 2016) 3 58

Products for MIR574 Gene

Sources for MIR574 Gene

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