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Aliases for MIR570 Gene

Subcategory (RNA class) for MIR570 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR570 Gene

  • MicroRNA 570 2 3 5
  • Hsa-Mir-570 3
  • MIRN570 3

External Ids for MIR570 Gene

Previous HGNC Symbols for MIR570 Gene

  • MIRN570

Previous GeneCards Identifiers for MIR570 Gene

  • GC03P196912
  • GC03P195426
  • GC03P195700
  • GC03P195703

Summaries for MIR570 Gene

Entrez Gene Summary for MIR570 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR570 Gene

MIR570 (MicroRNA 570) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR570 Gene

Genomics for MIR570 Gene

Regulatory Elements for MIR570 Gene

Enhancers for MIR570 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G196079 1.4 ENCODE dbSUPER 10.5 +381.6 381581 4.5 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D GLIS1 MUC4 ACAP2 UBXN7 MIR570 ENSG00000230732 MUC20 LINC00969 SDHAP1 LOC100131360 ENSG00000260261
GH03G195884 1.3 Ensembl ENCODE dbSUPER 11.3 +186.6 186642 2.8 TCF12 GLIS2 ZNF766 GATA2 EGR1 FOS EGR2 ELF1 ZNF592 SMARCA4 MUC4 MIR570 LINC00969 SDHAP2 MIR6829 TNK2-AS1
GH03G195747 1.2 Ensembl ENCODE 11.7 +48.7 48684 0.7 HDAC1 YBX3 HDGF CBX3 RB1 YBX1 RAD21 EGR1 CREM SMARCA5 MUC20 MUC20P1 MUC4 MIR570 LINC00969 PIR47199 GC03M195779 GC03M195778
GH03G196567 1.1 ENCODE 10.5 +869.4 869389 2.6 HDGF CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 RNF168 CEP19 LINC01063 SDHAP2 MIR570 NCBP2 NCBP2-AS1 RNU6-910P TM4SF19 FBXO45
GH03G195727 0.6 ENCODE 12.9 +29.5 29476 2.2 PAX8 REST HIC1 GATA3 GATA1 HNF4A ZBTB33 HES1 TCF7L2 LINC00969 MUC20 MUC20P1 MIR570 ENSG00000271662 MUC4 SDHAP2 PIR47199 GC03M195778 GC03M195779
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR570 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR570 Gene

Chromosome:
3
Start:
195,699,401 bp from pter
End:
195,699,497 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR570 Gene

Genes around MIR570 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR570 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR570 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR570 Gene

Post-translational modifications for MIR570 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR570 Gene

Domains & Families for MIR570 Gene

Gene Families for MIR570 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR570: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR570 Gene

Function for MIR570 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR570 Gene

Localization for MIR570 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR570 Gene

Pathways & Interactions for MIR570 Gene

SuperPathways for MIR570 Gene

No Data Available

Interacting Proteins for MIR570 Gene

Gene Ontology (GO) - Biological Process for MIR570 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR570 Gene

Drugs & Compounds for MIR570 Gene

No Compound Related Data Available

Transcripts for MIR570 Gene

mRNA/cDNA for MIR570 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR570 Gene

No ASD Table

Relevant External Links for MIR570 Gene

GeneLoc Exon Structure for
MIR570
ECgene alternative splicing isoforms for
MIR570

Expression for MIR570 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR570 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR570 Gene:

MIR570
genes like me logo Genes that share expression patterns with MIR570: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR570 Gene

Orthologs for MIR570 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR570 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 96 (a)
OneToOne
Species where no ortholog for MIR570 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR570 Gene

ENSEMBL:
Gene Tree for MIR570 (if available)
TreeFam:
Gene Tree for MIR570 (if available)

Paralogs for MIR570 Gene

No data available for Paralogs for MIR570 Gene

Variants for MIR570 Gene

Sequence variations from dbSNP and Humsavar for MIR570 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000225272 -- 195,697,509(+) CCCAT(G/T)CTTAA intron-variant, upstream-variant-2KB
rs1001756339 -- 195,697,568(+) ACGGC(A/G)CATCA intron-variant, upstream-variant-2KB
rs1002738165 -- 195,698,574(+) GAACA(C/T)TTTTC intron-variant, upstream-variant-2KB
rs1002767551 -- 195,698,429(+) TCTTC(A/C)TATCC intron-variant, upstream-variant-2KB
rs1004166365 -- 195,698,914(+) TCTTA(C/T)TCCCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR570 Gene

Variant ID Type Subtype PubMed ID
dgv185n111 CNV duplication 26073780
dgv2683n106 OTHER inversion 24896259
dgv2881e59 CNV duplication 20981092
dgv2883e59 CNV duplication 20981092
dgv5014n100 CNV gain 25217958
dgv5015n100 CNV loss 25217958
dgv5016n100 CNV gain+loss 25217958
dgv5017n100 CNV gain+loss 25217958
dgv5018n100 CNV loss 25217958
dgv5019n100 CNV gain+loss 25217958
dgv5020n100 CNV loss 25217958
dgv5021n100 CNV gain+loss 25217958
dgv5022n100 CNV gain 25217958
dgv5023n100 CNV loss 25217958
dgv5024n100 CNV gain 25217958
dgv5025n100 CNV gain+loss 25217958
dgv5026n100 CNV loss 25217958
dgv5027n100 CNV loss 25217958
dgv5028n100 CNV gain+loss 25217958
dgv5029n100 CNV gain 25217958
dgv8837n54 CNV loss 21841781
dgv8839n54 CNV loss 21841781
dgv8840n54 CNV loss 21841781
dgv8841n54 CNV loss 21841781
dgv905e199 CNV deletion 23128226
dgv967e214 CNV gain 21293372
esv2110612 CNV deletion 18987734
esv22821 CNV gain+loss 19812545
esv2429380 CNV gain 19546169
esv2453319 CNV insertion 19546169
esv2726477 CNV deletion 23290073
esv2726484 CNV deletion 23290073
esv2759213 CNV gain+loss 17122850
esv2760775 CNV gain+loss 21179565
esv2763776 CNV gain+loss 21179565
esv32809 CNV gain+loss 17666407
esv3361872 CNV duplication 20981092
nsv1001387 CNV gain 25217958
nsv1006165 CNV gain 25217958
nsv1006229 CNV gain 25217958
nsv1007562 CNV gain 25217958
nsv1008017 CNV loss 25217958
nsv1010930 CNV gain+loss 25217958
nsv1068315 OTHER inversion 25765185
nsv1077430 CNV duplication 25765185
nsv1110423 CNV duplication 24896259
nsv1141447 CNV duplication 24896259
nsv1148295 CNV duplication 26484159
nsv1161018 CNV deletion 26073780
nsv428430 CNV gain+loss 18775914
nsv436932 CNV loss 16327808
nsv469606 CNV gain+loss 16826518
nsv471621 CNV gain+loss 15918152
nsv593022 CNV gain 21841781
nsv593036 CNV loss 21841781
nsv820189 CNV gain 19587683
nsv820550 CNV duplication 20802225
nsv822408 CNV gain 20364138
nsv829825 CNV loss 17160897
nsv950300 CNV duplication 24416366
nsv998596 CNV gain+loss 25217958

Relevant External Links for MIR570 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR570

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR570 Gene

Disorders for MIR570 Gene

Relevant External Links for MIR570

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR570

No disorders were found for MIR570 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR570 Gene

Publications for MIR570 Gene

  1. miR-570 interacts with mitochondrial ATPase subunit g (ATP5L) encoding mRNA in stored platelets. (PMID: 27561077) Dahiya N. … Atreya C.D. (Platelets 2017) 3 64
  2. MicroRNA-570 promotes lung carcinoma proliferation through targeting tumor suppressor KLF9. (PMID: 26045791) Tong X.D. … Liu H.X. (Int J Clin Exp Pathol 2015) 3 64
  3. MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma. (PMID: 26084609) Guo W. … Wang C. (Tumour Biol. 2015) 3 64
  4. Single-Nucleotide Polymorphisms in Cytochrome P450 2E1 (CYP2E1) 3'-Untranslated Region Affect the Regulation of CYP2E1 by miR-570. (PMID: 26199425) Nakano M. … Nakajima M. (Drug Metab. Dispos. 2015) 3 64
  5. Evaluation of miR-27a, miR-181a, and miR-570 genetic variants with gallbladder cancer susceptibility and treatment outcome in a North Indian population. (PMID: 26288960) Gupta A. … Mittal B. (Mol Diagn Ther 2015) 3 64

Products for MIR570 Gene

Sources for MIR570 Gene

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