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MIR569 Gene(RNA Gene)

MicroRNA 569

GCID:
GC03M171106
GIFtS:
21
Genes Participants
UDN Logo

Aliases for MIR569 Gene

Subcategory (RNA class) for MIR569 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR569 Gene

  • MicroRNA 569 2 3 5
  • Hsa-Mir-569 3
  • MIRN569 3

External Ids for MIR569 Gene

ORGUL Members for MIR569 Gene

Previous HGNC Symbols for MIR569 Gene

  • MIRN569

Previous GeneCards Identifiers for MIR569 Gene

  • GC03M172308
  • GC03M170824

Summaries for MIR569 Gene

Entrez Gene Summary for MIR569 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR569 Gene

MIR569 (MicroRNA 569) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR569 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR569

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR569 Gene

Genomics for MIR569 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR569 Gene

Enhancers for MIR569 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G171021 1.4 Ensembl ENCODE dbSUPER 11.1 +81.2 81201 8.9 FOXA2 PKNOX1 YY1 GATA2 FOS MXD4 NFYC MAFF PBX2 HNF4A MIR569 TNIK RPL22L1 SLC2A2 RNU1-70P GC03M171007
GH03G171138 0.6 dbSUPER 11.7 -32.6 -32648 0.9 MAFG EP300 ZNF316 JUND EGR1 SCRT2 HNF4A MAFK EMSY MIR569 TNIK ENSG00000222506
GH03G171099 0.7 dbSUPER 0.7 +4.8 4843 4.9 LEF1 NFIB NR2F1 SUPT20H NFIC JUND ZNF316 FOXK2 IKZF1 CREB1 RPL22L1 TNIK MIR569 LOC105374216
GH03G171106 0.5 dbSUPER 0.7 -1.0 -1016 2.5 FOSL1 JUND CREB1 BCL11B TNIK MIR569 ENSG00000222506
GH03G171130 1 ENCODE dbSUPER 0.3 -23.8 -23768 0.2 SOX13 CTCF FOXA2 CEBPG RAD21 RERE SMC3 CREM GATAD2A SOX5 MIR569 ENSG00000222506
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR569 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR569 Gene

Chromosome:
3
Start:
171,106,664 bp from pter
End:
171,106,759 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR569 Gene

Genes around MIR569 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR569 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR569 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR569 Gene

ORGUL Member Location for MIR569 Gene

ORGUL Member Location for MIR569 gene

Proteins for MIR569 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR569 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR569 Gene

Domains & Families for MIR569 Gene

Gene Families for MIR569 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR569: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR569 Gene

Function for MIR569 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR569 Gene

Localization for MIR569 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR569 Gene

Pathways & Interactions for MIR569 Gene

SuperPathways for MIR569 Gene

PathCards logo More details on SuperPathways for MIR569
No Data Available

Interacting Proteins for MIR569 Gene

Gene Ontology (GO) - Biological Process for MIR569 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR569 Gene

Drugs & Compounds for MIR569 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR569 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR569 Gene

  • hsa-mir-569_MI0003576_Homo_sapiens_miR-569_stem-loop_hairpin

mRNA/cDNA for MIR569 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR569 Gene

No ASD Table

Relevant External Links for MIR569 Gene

GeneLoc Exon Structure for
MIR569
ECgene alternative splicing isoforms for
MIR569

Expression for MIR569 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR569 Gene

mRNA expression in normal human tissues for MIR569 Gene
mRNA expression by GTEx for MIR569 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR569 Gene:

MIR569
genes like me logo Genes that share expression patterns with MIR569: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR569 Gene

Orthologs for MIR569 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR569 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-569 35
  • 99 (a)
 OneToOne
Species where no ortholog for MIR569 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR569 Gene

ENSEMBL:
Gene Tree for MIR569 (if available)
TreeFam:
Gene Tree for MIR569 (if available)

Paralogs for MIR569 Gene

No data available for Paralogs for MIR569 Gene

Variants for MIR569 Gene

Sequence variations from dbSNP and Humsavar for MIR569 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001180048 -- 171,108,260(+) TTGAG(A/G)TTACT intron-variant, upstream-variant-2KB
rs1001380805 -- 171,108,003(+) ACTAC(C/T)TAATC intron-variant, upstream-variant-2KB
rs1002375631 -- 171,106,559(+) ATTCA(C/T)GCAGG intron-variant, downstream-variant-500B
rs1003056800 -- 171,106,240(+) GCTTT(C/T)ACACA intron-variant, downstream-variant-500B
rs1005267274 -- 171,107,665(+) CAGAA(A/G)AACTG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR569 Gene

Variant ID Type Subtype PubMed ID
nsv7356 OTHER inversion 18451855

Relevant External Links for MIR569 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR569

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR569 Gene

Disorders for MIR569 Gene

Relevant External Links for MIR569

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR569

No disorders were found for MIR569 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR569 Gene

Publications for MIR569 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. (PMID: 25490449) Chaluvally-Raghavan P. … Mills G.B. (Cancer Cell 2014) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR569 Gene

Sources for MIR569 Gene

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