Aliases for MIR569 Gene
Subcategory (RNA class) for MIR569 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR569 Gene
- HGNC: 32825
- Entrez Gene: 693154
- Ensembl: ENSG00000207963
- miRBase: hsa-mir-569
ORGUL Members for MIR569 Gene
Previous HGNC Symbols for MIR569 Gene
- MIRN569
Previous GeneCards Identifiers for MIR569 Gene
- GC03M172308
- GC03M170824
Summaries for MIR569 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR569 Gene
MIR569 (MicroRNA 569) is an RNA Gene, and is affiliated with the miRNA class.
fRNAdb sequence ontologies for MIR569 Gene - the ORGUL cluster for this gene includes several descriptions:
-
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR569 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR569 Gene
Genomics for MIR569 Gene
GeneHancer (GH) Regulatory Elements for MIR569 Gene
Promoters and enhancers for MIR569 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I171106 | Enhancer | 0.4 | dbSUPER | 550.8 | -1.0 | -1015 | 2.5 | FOSL1 JUND CREB1 | MIR569 TNIK LOC105374216 ENSG00000222506 | |
| GH03I171021 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 11.1 | +81.2 | 81200 | 8.9 | HDAC1 ELF3 PKNOX1 FOXA2 RAD21 YY1 MIXL1 RXRA NFYC MXD4 | SLC2A2 MIR569 TNIK RPL22L1 RNU1-70P GC03M171011 | |
| GH03I171138 | Enhancer | 0.5 | dbSUPER | 11.7 | -32.6 | -32648 | 0.9 | ZNF316 SCRT2 MAFG MAFK EMSY | MIR569 TNIK LOC105374216 ENSG00000222506 | |
| GH03I171099 | Enhancer | 0.5 | dbSUPER | 0.8 | +4.8 | 4843 | 4.9 | JUND NFIC NFIB CREB1 FOS | LOC105374216 RPL22L1 TNIK MIR569 | |
| GH03I171182 | Enhancer | 1.4 | Ensembl ENCODE dbSUPER | 0.2 | -76.0 | -76042 | 1.2 | ATF1 PKNOX1 ARNT TCF12 GATA2 E2F8 ARID2 ATF7 NCOA1 REST | TNIK MIR569 ENSG00000222506 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR569 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR569 Gene
Genomic Locations for MIR569 Gene
- chr3:171,106,664-171,106,759
- (GRCh38/hg38)
- Size:
- 96 bases
- Orientation:
- Minus strand
- chr3:170,824,453-170,824,548
- (GRCh37/hg19)
Genomic View for MIR569 Gene
Genes around MIR569 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q26.2 by Ensembl
- 3q26.2 by Entrez Gene
- 3q26.2 by HGNC
MIR569 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR569 Gene
ORGUL Member Location for MIR569 Gene
Proteins for MIR569 Gene
Post-translational modifications for MIR569 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR569
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR569
- Origene Custom Protein Services for MIR569
- Search GeneTex for Proteins for MIR569
No data available for DME Specific Peptides for MIR569 Gene
Domains & Families for MIR569 Gene
Gene Families for MIR569 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR569 Gene
Function for MIR569 Gene
Phenotypes From GWAS Catalog for MIR569 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR569
-
- Search ViGene Biosciences for MIR569
CRISPR Products
- Browse CRISPR knockouts for MIR569
- Applied Biological Materials CRISPR for MIR569
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR569
Clone Products
- GenScript: Custom all cDNA clones Services for MIR569
- VectorBuilder custom plasmid, inducible vectors for MIR569
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR569
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR569
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR569 Gene
Localization for MIR569 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR569 Gene
Transcripts for MIR569 Gene
fRNAdb Secondary structures for MIR569 Gene
mRNA/cDNA for MIR569 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR569
- Applied Biological Materials CRISPR for MIR569
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR569
Clone Products
- GenScript: Custom all cDNA clones Services for MIR569
- VectorBuilder custom plasmid, inducible vectors for MIR569
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR569
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR569
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR569 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR569 Gene:
MIR569Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR569 Gene
Orthologs for MIR569 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-569 34 |
|
OneToOne |
- Species where no ortholog for MIR569 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR569 Gene
No data available for Paralogs for MIR569 Gene
Variants for MIR569 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001180048 | -- | 171,108,260(-) | A/G | upstream_transcript_variant | |
| rs1001380805 | -- | 171,108,003(-) | T/C | upstream_transcript_variant | |
| rs1002375631 | -- | 171,106,559(-) | T/C | downstream_transcript_variant | |
| rs1003056800 | -- | 171,106,240(-) | C/T | downstream_transcript_variant | |
| rs1005267274 | -- | 171,107,665(-) | A/G | upstream_transcript_variant |
Additional Variant Information for MIR569 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR569
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR569 Gene
Disorders for MIR569 Gene
Additional Disease Information for MIR569
No disorders were found for MIR569 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR569 Gene
Publications for MIR569 Gene
- The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
- Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. (PMID: 25490449) Chaluvally-Raghavan P … Mills GB (Cancer cell 2014) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR569 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody Services
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- GenScript: Custom all cDNA clones Services for MIR569
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- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Novus Biologicals
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- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR569
- VectorBuilder custom plasmid, inducible vectors for MIR569
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR569
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR569
- Search GeneTex for Proteins for MIR569
Sources for MIR569 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew