Aliases for MIR568 Gene
Subcategory (RNA class) for MIR568 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR568 Gene
- HGNC: 32824
- Entrez Gene: 693153
- Ensembl: ENSG00000284134
- miRBase: hsa-mir-568
ORGUL Members for MIR568 Gene
Previous HGNC Symbols for MIR568 Gene
- MIRN568
Previous GeneCards Identifiers for MIR568 Gene
- GC03U901158
- GC03M115520
- GC03M114035
Summaries for MIR568 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR568 Gene
MIR568 (MicroRNA 568) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR568 include Keratoconus.
fRNAdb sequence ontologies for MIR568 Gene - the ORGUL cluster for this gene includes several descriptions:
-
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR568 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR568 Gene
Genomics for MIR568 Gene
GeneHancer (GH) Regulatory Elements for MIR568 Gene
Promoters and enhancers for MIR568 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I114312 | Enhancer | 0.4 | dbSUPER | 550.8 | +0.5 | 517 | 6.7 | ZSCAN4 JUNB RUNX3 | MIR568 ZBTB20-AS1 CFAP44-AS1 ENSG00000259976 TIGIT ZBTB20 | |
| GH03I114319 | Enhancer | 0.8 | Ensembl ENCODE | 0.8 | -3.1 | -3069 | 0.3 | FOXA2 JUN HLF MAX CEBPB MNT SP1 JUND POLR2A FOS | MIR568 ENSG00000259976 ZBTB20 | |
| GH03I114290 | Promoter/Enhancer | 1.7 | EPDnew Ensembl ENCODE dbSUPER | 0.3 | +22.9 | 22942 | 6.4 | HDGF PKNOX1 RB1 BMI1 BATF KLF5 RAD21 ZNF143 ATF7 ETV6 | TIGIT DRD3 ZBTB20 MIR568 | |
| GH03I114306 | Enhancer | 0.9 | ENCODE dbSUPER | 0.4 | +8.3 | 8321 | 2.8 | EBF1 BATF IRF4 RELA ZSCAN29 ETV6 BCLAF1 IKZF2 RUNX3 SRF | CFAP44-AS1 MIR568 TIGIT | |
| GH03I114299 | Enhancer | 0.8 | ENCODE dbSUPER | 0.4 | +16.8 | 16813 | 0.8 | CTCF PKNOX1 RFX1 HLF ZNF644 RAD21 E4F1 SMC3 | MIR568 TIGIT |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR568 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR568 Gene
Genomic Locations for MIR568 Gene
- chr3:114,316,475-114,316,569
- (GRCh38/hg38)
- Size:
- 95 bases
- Orientation:
- Minus strand
- chr3:114,035,322-114,035,416
- (GRCh37/hg19)
Genomic View for MIR568 Gene
Genes around MIR568 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q13.31 by Ensembl
- 3q13.31 by Entrez Gene
- 3q13.31 by HGNC
MIR568 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR568 Gene
ORGUL Member Location for MIR568 Gene
Proteins for MIR568 Gene
Post-translational modifications for MIR568 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR568
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR568
- Origene Custom Protein Services for MIR568
- Search GeneTex for Proteins for MIR568
No data available for DME Specific Peptides for MIR568 Gene
Domains & Families for MIR568 Gene
Gene Families for MIR568 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR568 Gene
Function for MIR568 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR568
-
- Search ViGene Biosciences for MIR568
CRISPR Products
- Browse CRISPR knockouts for MIR568
- Applied Biological Materials CRISPR for MIR568
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR568
Clone Products
- GenScript: Custom all cDNA clones Services for MIR568
- VectorBuilder custom plasmid, inducible vectors for MIR568
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR568
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR568
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR568 Gene
Localization for MIR568 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR568 Gene
Transcripts for MIR568 Gene
fRNAdb Secondary structures for MIR568 Gene
mRNA/cDNA for MIR568 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR568
- Applied Biological Materials CRISPR for MIR568
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR568
Clone Products
- GenScript: Custom all cDNA clones Services for MIR568
- VectorBuilder custom plasmid, inducible vectors for MIR568
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR568
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR568
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR568 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR568 Gene:
MIR568Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR568 Gene
Orthologs for MIR568 Gene
No data available for Orthologs for MIR568 Gene
Paralogs for MIR568 Gene
No data available for Paralogs for MIR568 Gene
Variants for MIR568 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001531519 | -- | 114,317,262(-) | T/C | upstream_transcript_variant | |
| rs1002339229 | -- | 114,317,270(-) | T/C | upstream_transcript_variant | |
| rs1002882046 | -- | 114,316,956(-) | C/T | upstream_transcript_variant | |
| rs1007323379 | -- | 114,317,917(-) | A/T | upstream_transcript_variant | |
| rs1009698573 | -- | 114,316,665(-) | A/C | upstream_transcript_variant |
Additional Variant Information for MIR568 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR568
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR568 Gene
Disorders for MIR568 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| keratoconus |
|
|
Search MIR568 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR568
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR568 Gene
Publications for MIR568 Gene
- The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
- Mutational Analysis of Pre-miR-184 and hsa-mir-568 in Greek Patients With Sporadic Keratoconus. (PMID: 26845316) Moschos MM … Gazouli M (Cornea 2016) 3 58
- Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium. (PMID: 24053186) Adyshev DM … Garcia JG (American journal of respiratory cell and molecular biology 2014) 3 58
- MiR-568 inhibits the activation and function of CD4⁺ T cells and Treg cells by targeting NFAT5. (PMID: 24355664) Li W … Yang AG (International immunology 2014) 3 58
- Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis. (PMID: 25311085) Li JT … Yang AG (Breast cancer research : BCR 2014) 3 58
Products for MIR568 Gene
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- Browse R&D Systems for biochemical assays
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR568
- VectorBuilder custom plasmid, inducible vectors for MIR568
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR568
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR568
- Search GeneTex for Proteins for MIR568
Sources for MIR568 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew