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MIR568 Gene(RNA Gene)

MicroRNA 568

GCID:
GC03M114316
GIFtS:
18
Genes Participants
UDN Logo

Aliases for MIR568 Gene

Subcategory (RNA class) for MIR568 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR568 Gene

  • MicroRNA 568 2 3 5
  • Hsa-Mir-568 3
  • MIRN568 3

External Ids for MIR568 Gene

ORGUL Members for MIR568 Gene

Previous HGNC Symbols for MIR568 Gene

  • MIRN568

Previous GeneCards Identifiers for MIR568 Gene

  • GC03U901158
  • GC03M115520
  • GC03M114035

Summaries for MIR568 Gene

Entrez Gene Summary for MIR568 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR568 Gene

MIR568 (MicroRNA 568) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR568 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR568

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR568 Gene

Genomics for MIR568 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR568 Gene

Enhancers for MIR568 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G114319 0.9 Ensembl ENCODE 0.7 -3.1 -3069 0.3 ZNF146 FOXA2 JUN HLF TEAD4 MAX CEBPB MNT CHD7 JUND MIR568 ENSG00000259976
GH03G114312 0.6 dbSUPER 0.7 +0.5 518 6.7 GATA2 SCRT2 ZSCAN4 JUNB NFE2 CHD7 NFE2L2 ZBTB20-AS1 CFAP44-AS1 MIR568 TIGIT
GH03G114290 1.4 Ensembl ENCODE dbSUPER 0.3 +22.9 22942 6.4 HDGF PKNOX1 WRNIP1 BMI1 RAD21 CBX5 ZNF143 RELB ETV6 IKZF2 DRD3 TIGIT ZBTB20 MIR568
GH03G114306 1 ENCODE dbSUPER 0.4 +8.3 8321 2.8 USF1 TBL1XR1 MAX ASH2L RELA ELK1 POLR2A EED ZSCAN29 ETV6 CFAP44-AS1 MIR568 TIGIT
GH03G114322 0.8 ENCODE dbSUPER 0.4 -7.1 -7082 1.7 SOX5 CTCF MTA2 BHLHE40 IKZF1 IKZF2 TBX21 MIR568 ENSG00000259976
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR568 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR568 Gene

Chromosome:
3
Start:
114,316,475 bp from pter
End:
114,316,569 bp from pter
Size:
95 bases
Orientation:
Minus strand

Genomic View for MIR568 Gene

Genes around MIR568 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR568 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR568 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR568 Gene

ORGUL Member Location for MIR568 Gene

ORGUL Member Location for MIR568 gene

Proteins for MIR568 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR568 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR568 Gene

Domains & Families for MIR568 Gene

Gene Families for MIR568 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR568: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR568 Gene

Function for MIR568 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR568 Gene

Localization for MIR568 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR568 Gene

Pathways & Interactions for MIR568 Gene

SuperPathways for MIR568 Gene

PathCards logo More details on SuperPathways for MIR568
No Data Available

Interacting Proteins for MIR568 Gene

Gene Ontology (GO) - Biological Process for MIR568 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR568 Gene

Drugs & Compounds for MIR568 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR568 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

fRNAdb Secondary structures for MIR568 Gene

  • FR148807
  • hsa-mir-568_MI0003574_Homo_sapiens_miR-568_stem-loop_hairpin

mRNA/cDNA for MIR568 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR568 Gene

No ASD Table

Relevant External Links for MIR568 Gene

GeneLoc Exon Structure for
MIR568
ECgene alternative splicing isoforms for
MIR568

Expression for MIR568 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR568 Gene

mRNA expression in normal human tissues for MIR568 Gene
mRNA expression by GTEx for MIR568 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR568 Gene:

MIR568
genes like me logo Genes that share expression patterns with MIR568: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR568 Gene

Orthologs for MIR568 Gene

Evolution for MIR568 Gene

ENSEMBL:
Gene Tree for MIR568 (if available)
TreeFam:
Gene Tree for MIR568 (if available)

No data available for Orthologs for MIR568 Gene

Paralogs for MIR568 Gene

No data available for Paralogs for MIR568 Gene

Variants for MIR568 Gene

Sequence variations from dbSNP and Humsavar for MIR568 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1001531519 -- 114,317,262(+) TACCA(C/T)TCGTT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1002339229 -- 114,317,270(+) GTTTG(C/T)GTGTA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1002882046 -- 114,316,956(+) GTTTA(C/T)GTATC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1007323379 -- 114,317,917(+) GAAAA(A/T)GGAAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1009698573 -- 114,316,665(+) GCTTT(A/C)ATTTA nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Relevant External Links for MIR568 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR568

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR568 Gene

Disorders for MIR568 Gene

Relevant External Links for MIR568

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR568

No disorders were found for MIR568 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR568 Gene

Publications for MIR568 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Mutational Analysis of Pre-miR-184 and hsa-mir-568 in Greek Patients With Sporadic Keratoconus. (PMID: 26845316) Moschos M.M. … Gazouli M. (Cornea 2016) 3 64
  3. Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium. (PMID: 24053186) Adyshev D.M. … Garcia J.G. (Am. J. Respir. Cell Mol. Biol. 2014) 3 64
  4. MiR-568 inhibits the activation and function of CD4a8_ T cells and Treg cells by targeting NFAT5. (PMID: 24355664) Li W. … Yang A.G. (Int. Immunol. 2014) 3 64
  5. Nuclear factor of activated T cells 5 maintained by Hotair suppression of miR-568 upregulates S100 calcium binding protein A4 to promote breast cancer metastasis. (PMID: 25311085) Li J.T. … Yang A.G. (Breast Cancer Res. 2014) 3 64

Products for MIR568 Gene

Sources for MIR568 Gene

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