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Aliases for MIR564 Gene

Subcategory (RNA class) for MIR564 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR564 Gene

  • MicroRNA 564 2 3
  • TMEM42 4 5
  • Transmembrane Protein 42 5
  • Hsa-Mir-564 3
  • MIRN564 3

External Ids for MIR564 Gene

Previous HGNC Symbols for MIR564 Gene

  • MIRN564

Previous GeneCards Identifiers for MIR564 Gene

  • GC03P044881
  • GC03P044903
  • GC03P044865
  • GC03P044867
  • GC03P044869
  • GC03P044912

Summaries for MIR564 Gene

Entrez Gene Summary for MIR564 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR564 Gene

MIR564 (MicroRNA 564) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR564 Gene

Genomics for MIR564 Gene

Regulatory Elements for MIR564 Gene


Promoters for MIR564 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001362523 32 1800 ATF1 ZFP64 SIN3A ARID4B DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF207

Genomic Location for MIR564 Gene

Chromosome:
3
Start:
44,861,869 bp from pter
End:
44,865,670 bp from pter
Size:
3,802 bases
Orientation:
Plus strand

Genomic View for MIR564 Gene

Genes around MIR564 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR564 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR564 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR564 Gene

Proteins for MIR564 Gene

  • Protein details for MIR564 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YG0-TMM42_HUMAN
    Recommended name:
    Transmembrane protein 42
    Protein Accession:
    Q69YG0
    Secondary Accessions:
    • Q8WUQ6

    Protein attributes for MIR564 Gene

    Size:
    159 amino acids
    Molecular mass:
    16991 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIR564 Gene

Post-translational modifications for MIR564 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR564 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR564 Gene

Domains & Families for MIR564 Gene

Gene Families for MIR564 Gene

Protein Domains for MIR564 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR564: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR564 Gene

Function for MIR564 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR564 Gene

Localization for MIR564 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR564 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR564 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR564: view

No data available for Subcellular locations from COMPARTMENTS for MIR564 Gene

Pathways & Interactions for MIR564 Gene

SuperPathways for MIR564 Gene

No Data Available

Interacting Proteins for MIR564 Gene

Gene Ontology (GO) - Biological Process for MIR564 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR564 Gene

Transcripts for MIR564 Gene

mRNA/cDNA for MIR564 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR564 Gene

No ASD Table

Relevant External Links for MIR564 Gene

GeneLoc Exon Structure for
MIR564
ECgene alternative splicing isoforms for
MIR564

Expression for MIR564 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR564 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR564 Gene:

MIR564
genes like me logo Genes that share expression patterns with MIR564: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR564 Gene

Orthologs for MIR564 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR564 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM42 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM42 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM42 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem42 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM42 35
  • 33 (a)
OneToOne
Species where no ortholog for MIR564 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR564 Gene

ENSEMBL:
Gene Tree for MIR564 (if available)
TreeFam:
Gene Tree for MIR564 (if available)

Paralogs for MIR564 Gene

No data available for Paralogs for MIR564 Gene

Variants for MIR564 Gene

Sequence variations from dbSNP and Humsavar for MIR564 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs112667895 -- 44,859,965(+) ATCAC(G/T)TCAGC upstream-variant-2KB
rs112799956 -- 44,862,193(+) CGCTG(C/G)GGGGC intron-variant, downstream-variant-500B
rs114582885 -- 44,861,445(+) GCGTC(C/T)TTCTG upstream-variant-2KB
rs114636202 -- 44,861,893(+) CGGGC(A/G)GCGGG nc-transcript-variant, upstream-variant-2KB
rs115139289 -- 44,861,724(+) CCTAC(C/T)ACAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR564 Gene

Variant ID Type Subtype PubMed ID
nsv834675 CNV gain 17160897
nsv3792 CNV deletion 18451855

Relevant External Links for MIR564 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR564

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR564 Gene

Disorders for MIR564 Gene

Relevant External Links for MIR564

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR564

No disorders were found for MIR564 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR564 Gene

Publications for MIR564 Gene

  1. MiR-564 functions as a tumor suppressor in human lung cancer by targeting ZIC3. (PMID: 26498524) Yang B. … Xie T. (Biochem. Biophys. Res. Commun. 2015) 3 64
  2. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini A.A. … Barker J.N. (Nat Commun 2014) 3 64
  3. Downregulation of miR-31, miR-155, and miR-564 in chronic myeloid leukemia cells. (PMID: 22511990) Rokah O.H. … Shpilberg O. (PLoS ONE 2012) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR564 Gene

Sources for MIR564 Gene

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