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Aliases for MIR559 Gene

Subcategory (RNA class) for MIR559 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR559 Gene

  • MicroRNA 559 2 3 5
  • Hsa-Mir-559 3
  • MIRN559 3

External Ids for MIR559 Gene

ORGUL Members for MIR559 Gene

Previous HGNC Symbols for MIR559 Gene

  • MIRN559

Previous GeneCards Identifiers for MIR559 Gene

  • GC02P047459
  • GC02P047605
  • GC02P047606
  • GC02P047379
  • GC02P047380
  • GC02P047381
  • GC02P047382
  • GC02P047384

Summaries for MIR559 Gene

Entrez Gene Summary for MIR559 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR559 Gene

MIR559 (MicroRNA 559) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR559 Gene

Genomics for MIR559 Gene

Regulatory Elements for MIR559 Gene

Enhancers for MIR559 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G047297 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -78.0 -78018 3.7 PKNOX1 FOXA2 ATF1 ZNF766 ELK1 KLF13 CAVIN1 ZNF592 MEF2D CREB3 LOC101927043 EPCAM CALM2 MIR559 KCNK12 PIR58315 PIR36995
GH02G047336 1.5 Ensembl ENCODE dbSUPER 11.8 -40.7 -40719 1.8 PKNOX1 ATF1 TCF12 ZNF766 GATA2 ZNF207 NCOA1 TBX21 ZNF592 MBD2 MIR559 LOC101927043 BCYRN1
GH02G047334 1.4 Ensembl ENCODE dbSUPER 11.2 -42.8 -42759 1.5 ARNT ARID4B ZNF2 TCF12 ZNF121 ZNF766 GATA2 ZNF143 ZNF263 NCOA1 MIR559 BCYRN1 GC02P047335 GC02M047306
GH02G047302 0.8 dbSUPER 10.6 -73.4 -73436 2.9 PKNOX1 TCF12 FOS PRDM6 SMARCA4 IKZF1 PBX2 HMBOX1 KDM1A SP7 MIR559 LOC101927043 GC02M047305 PIR58315
GH02G047304 0.8 dbSUPER 10.6 -73.7 -73705 0.5 TAL1 JUN CEBPG FOSL1 TCF12 NCOR1 FOS SMARCE1 HLF NR3C1 MIR559 LOC101927043 GC02M047305 PIR58315
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR559 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR559 Gene

Chromosome:
2
Start:
47,377,675 bp from pter
End:
47,377,770 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR559 Gene

Genes around MIR559 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR559 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR559 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR559 Gene

Proteins for MIR559 Gene

Post-translational modifications for MIR559 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR559 Gene

Domains & Families for MIR559 Gene

Gene Families for MIR559 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR559: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR559 Gene

Function for MIR559 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR559 Gene

Localization for MIR559 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR559 Gene

Pathways & Interactions for MIR559 Gene

SuperPathways for MIR559 Gene

No Data Available

Interacting Proteins for MIR559 Gene

Gene Ontology (GO) - Biological Process for MIR559 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR559 Gene

Transcripts for MIR559 Gene

mRNA/cDNA for MIR559 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR559 Gene

No ASD Table

Relevant External Links for MIR559 Gene

GeneLoc Exon Structure for
MIR559
ECgene alternative splicing isoforms for
MIR559

Expression for MIR559 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR559 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR559 Gene:

MIR559
genes like me logo Genes that share expression patterns with MIR559: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR559 Gene

Orthologs for MIR559 Gene

Evolution for MIR559 Gene

ENSEMBL:
Gene Tree for MIR559 (if available)
TreeFam:
Gene Tree for MIR559 (if available)

No data available for Orthologs for MIR559 Gene

Paralogs for MIR559 Gene

No data available for Paralogs for MIR559 Gene

Variants for MIR559 Gene

Sequence variations from dbSNP and Humsavar for MIR559 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs606231204 Pathogenic 47,377,021(+) ACTTC(-/C)AGAAG upstream-variant-2KB, reference, frameshift-variant
rs606231281 Pathogenic 47,377,012(+) TTTAC(A/G)GTGCA upstream-variant-2KB, splice-acceptor-variant
rs878854491 Pathogenic 47,377,045(+) GTTAT(C/T)AACTG upstream-variant-2KB, reference, stop-gained
rs146685071 Likely benign 47,377,015(+) ACAGT(A/G)CACTT upstream-variant-2KB, reference, missense
rs371372017 Likely benign 47,377,038(+) ACAAC(A/C/G)CGTTA upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR559 Gene

Variant ID Type Subtype PubMed ID
nsv1004828 CNV gain 25217958
nsv1009586 CNV gain 25217958
nsv999576 CNV gain 25217958

Relevant External Links for MIR559 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR559

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR559 Gene

Disorders for MIR559 Gene

Relevant External Links for MIR559

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR559

No disorders were found for MIR559 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR559 Gene

Publications for MIR559 Gene

  1. Preliminary validation of ERBB2 expression regulated by miR-548d-3p and miR-559. (PMID: 19486885) Chen H. … Chen Z.T. (Biochem. Biophys. Res. Commun. 2009) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  3. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR559 Gene

Sources for MIR559 Gene

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