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Aliases for MIR5588 Gene

Subcategory (RNA class) for MIR5588 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5588 Gene

  • MicroRNA 5588 2 3 5
  • Hsa-Mir-5588 3

External Ids for MIR5588 Gene

Previous GeneCards Identifiers for MIR5588 Gene

  • GC03U901831
  • GC03M184974

Summaries for MIR5588 Gene

Entrez Gene Summary for MIR5588 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5588 Gene

MIR5588 (MicroRNA 5588) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5588 Gene

Genomics for MIR5588 Gene

Regulatory Elements for MIR5588 Gene

Enhancers for MIR5588 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F185253 1 ENCODE 0.8 -0.8 -841 1.1 ATF1 DMAP1 ZNF48 YY1 GLIS2 SP3 NFYC MXD4 REST PPARG VPS8 MAP3K13 MIR5588 EHHADH
GH03F185250 0.8 ENCODE 0.8 +2.4 2439 1.5 SOX13 ELF3 TFAP4 SAP130 RARA HNF4G CREM ZNF652 MIXL1 SOX5 VPS8 MAP3K13 EIF2S2P2 MIR5588
GH03F185254 0.6 ENCODE 0.8 -0.1 -76 0.2 SOX13 GATAD2A GTF2E2 HNF4G ZNF384 HMG20A HNF4A MIR5588 EHHADH
GH03F185280 1.1 Ensembl ENCODE 0.3 -27.5 -27530 0.4 ELF3 CTCF HDAC1 ATF1 CBX3 SAP130 ARID4B RAD21 RFX5 FOXK2 EHHADH MIR5588
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5588 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5588 Gene

Chromosome:
3
Start:
185,253,210 bp from pter
End:
185,253,272 bp from pter
Size:
63 bases
Orientation:
Minus strand

Genomic View for MIR5588 Gene

Genes around MIR5588 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5588 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5588 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5588 Gene

ORGUL Member Location for MIR5588 Gene

ORGUL Member Location for MIR5588 gene

Proteins for MIR5588 Gene

Post-translational modifications for MIR5588 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5588 Gene

Domains & Families for MIR5588 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5588 Gene

Function for MIR5588 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5588 Gene

Localization for MIR5588 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5588 Gene

Pathways & Interactions for MIR5588 Gene

SuperPathways for MIR5588 Gene

No Data Available

Interacting Proteins for MIR5588 Gene

Gene Ontology (GO) - Biological Process for MIR5588 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5588 Gene

Transcripts for MIR5588 Gene

mRNA/cDNA for MIR5588 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5588 Gene

No ASD Table

Relevant External Links for MIR5588 Gene

GeneLoc Exon Structure for
MIR5588
ECgene alternative splicing isoforms for
MIR5588

Expression for MIR5588 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5588 Gene:

MIR5588
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5588 Gene

Orthologs for MIR5588 Gene

Evolution for MIR5588 Gene

ENSEMBL:
Gene Tree for MIR5588 (if available)
TreeFam:
Gene Tree for MIR5588 (if available)

No data available for Orthologs for MIR5588 Gene

Paralogs for MIR5588 Gene

No data available for Paralogs for MIR5588 Gene

Variants for MIR5588 Gene

Sequence variations from dbSNP and Humsavar for MIR5588 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs398124646 Pathogenic 185,254,016(-) TGGCC(A/G)AGTAT intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113367839 -- 185,253,589(+) AAAAT(-/AAA)AAAAA intron-variant, upstream-variant-2KB
rs113562107 -- 185,253,589(+) AAAAA(A/T)AAAAA intron-variant, upstream-variant-2KB
rs114008428 -- 185,254,860(+) ATTGT(A/G)GAACC intron-variant, upstream-variant-2KB
rs114147868 -- 185,252,917(+) TTTCA(A/G)GGCTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR5588 Gene

Variant ID Type Subtype PubMed ID
nsv829817 CNV gain 17160897
dgv5002n100 CNV gain 25217958

Relevant External Links for MIR5588 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5588

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5588 Gene

Disorders for MIR5588 Gene

Relevant External Links for MIR5588

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5588

No disorders were found for MIR5588 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5588 Gene

Publications for MIR5588 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5588 Gene

Sources for MIR5588 Gene

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