Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR5586 Gene

Subcategory (RNA class) for MIR5586 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5586 Gene

  • MicroRNA 5586 2 3 5
  • Hsa-Mir-5586 3

External Ids for MIR5586 Gene

Previous GeneCards Identifiers for MIR5586 Gene

  • GC14U901315
  • GC14M060116

Summaries for MIR5586 Gene

Entrez Gene Summary for MIR5586 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5586 Gene

MIR5586 (MicroRNA 5586) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5586 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5586 Gene

Genomics for MIR5586 Gene

GeneHancer (GH) Regulatory Elements for MIR5586 Gene

Promoters and enhancers for MIR5586 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I059630 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.4 +16.4 16419 0.4 MXI1 L3MBTL2 SP2 HIC1 ZFHX2 GLIS2 POLR2A SCRT2 ZNF341 CTBP2 RTN1 MIR5586 GC14M059571
GH14I059595 Enhancer 0.5 ENCODE 0.2 +51.6 51586 0.7 LCORL NFIC SMAD1 ZNF544 NFIA NFIB HNF4A L3HYPDH JKAMP GC14M059571 MIR5586
GH14I059621 Enhancer 0.2 ENCODE 0.3 +24.4 24363 1.4 L3HYPDH CCDC175 MIR5586 GC14M059571 RTN1
GH14I059600 Enhancer 0.3 ENCODE 0.2 +46.1 46070 1.8 CREB1 L3HYPDH RTN1 JKAMP GC14M059571 MIR5586
GH14I059594 Enhancer 0.2 FANTOM5 0.2 +52.3 52280 0.3 L3HYPDH JKAMP RTN1 DAAM1 CCDC175 GC14M059571 MIR5586
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR5586 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5586 Gene

Genomic Locations for MIR5586 Gene
chr14:59,646,962-59,647,020
(GRCh38/hg38)
Size:
59 bases
Orientation:
Minus strand
chr14:60,113,680-60,113,738
(GRCh37/hg19)

Genomic View for MIR5586 Gene

Genes around MIR5586 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5586 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5586 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5586 Gene

ORGUL Member Location for MIR5586 Gene

ORGUL Member Location for MIR5586 gene

Proteins for MIR5586 Gene

Post-translational modifications for MIR5586 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5586 Gene

Domains & Families for MIR5586 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5586 Gene

Function for MIR5586 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5586 Gene

Localization for MIR5586 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5586 Gene

Pathways & Interactions for MIR5586 Gene

SuperPathways for MIR5586 Gene

No Data Available

Interacting Proteins for MIR5586 Gene

Gene Ontology (GO) - Biological Process for MIR5586 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5586 Gene

Drugs & Compounds for MIR5586 Gene

No Compound Related Data Available

Transcripts for MIR5586 Gene

mRNA/cDNA for MIR5586 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5586 Gene

No ASD Table

Relevant External Links for MIR5586 Gene

GeneLoc Exon Structure for
MIR5586
ECgene alternative splicing isoforms for
MIR5586

Expression for MIR5586 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5586 Gene:

MIR5586
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5586 Gene

Orthologs for MIR5586 Gene

Evolution for MIR5586 Gene

ENSEMBL:
Gene Tree for MIR5586 (if available)
TreeFam:
Gene Tree for MIR5586 (if available)

No data available for Orthologs for MIR5586 Gene

Paralogs for MIR5586 Gene

No data available for Paralogs for MIR5586 Gene

Variants for MIR5586 Gene

Sequence variations from dbSNP and Humsavar for MIR5586 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000515470 -- 59,646,928(-) A/C downstream_transcript_variant
rs1001156646 -- 59,646,628(-) G/A downstream_transcript_variant
rs1001871851 -- 59,646,951(-) G/T downstream_transcript_variant
rs1001920799 -- 59,647,160(-) T/C upstream_transcript_variant
rs1004283268 -- 59,648,050(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR5586 Gene

Variant ID Type Subtype PubMed ID
nsv832811 CNV loss 17160897

Additional Variant Information for MIR5586 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5586

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5586 Gene

Disorders for MIR5586 Gene

Additional Disease Information for MIR5586

No disorders were found for MIR5586 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5586 Gene

Publications for MIR5586 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR5586 Gene

Sources for MIR5586 Gene

Content
Loading form....