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Aliases for MIR5580 Gene

Subcategory (RNA class) for MIR5580 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5580 Gene

  • MicroRNA 5580 2 3 5
  • Hsa-Mir-5580 3

External Ids for MIR5580 Gene

Previous GeneCards Identifiers for MIR5580 Gene

  • GC14U901303
  • GC14M054419

Summaries for MIR5580 Gene

Entrez Gene Summary for MIR5580 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5580 Gene

MIR5580 (MicroRNA 5580) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5580 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5580 Gene

Genomics for MIR5580 Gene

Regulatory Elements for MIR5580 Gene

Enhancers for MIR5580 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H053946 1.2 Ensembl ENCODE dbSUPER 0.7 +1.6 1585 1 CTCF SOX13 ESRRA FOXA2 SIN3A RARA E2F1 EZH2 SMARCE1 MAZ BMP4 MIR5580 ENSG00000231922
GH14H053950 1.5 VISTA ENCODE dbSUPER 0.4 -6.0 -6010 7 ARID4B SIN3A FEZF1 ZBTB7B ETS1 ZNF121 ELK1 PAF1 SP3 SP5 BMP4 MIR5580
GH14H053942 1.1 Ensembl ENCODE 0.4 +5.0 5043 1 FOXA2 MLX ARID4B RAD21 THRB RARA CREM MIXL1 THAP11 HMG20B BMP4 MIR5580 ENSG00000231922
GH14H053924 0.9 ENCODE dbSUPER 0.3 +23.5 23467 1 FOXA2 JUN USF2 MAX CEBPB FOXA1 GATA3 FOS RUNX3 MAFK ENSG00000231922 MIR5580
GH14H053927 0.6 ENCODE 0.3 +21.0 21040 0 SOX5 SOX13 FOXA2 TEAD1 FOXA3 JUN TEAD3 CEBPA ATF7 HOMEZ BMP4 ENSG00000231922 MIR5580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5580 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5580 Gene

Chromosome:
14
Start:
53,948,427 bp from pter
End:
53,948,484 bp from pter
Size:
58 bases
Orientation:
Minus strand

Genomic View for MIR5580 Gene

Genes around MIR5580 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5580 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5580 Gene

ORGUL Member Location for MIR5580 Gene

ORGUL Member Location for MIR5580 gene

Proteins for MIR5580 Gene

Post-translational modifications for MIR5580 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5580 Gene

Domains & Families for MIR5580 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5580 Gene

Function for MIR5580 Gene

Phenotypes From GWAS Catalog for MIR5580 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR5580
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5580 Gene

Localization for MIR5580 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5580 Gene

Pathways & Interactions for MIR5580 Gene

SuperPathways for MIR5580 Gene

No Data Available

Interacting Proteins for MIR5580 Gene

Gene Ontology (GO) - Biological Process for MIR5580 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5580 Gene

Drugs & Compounds for MIR5580 Gene

No Compound Related Data Available

Transcripts for MIR5580 Gene

mRNA/cDNA for MIR5580 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR5580
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5580 Gene

No ASD Table

Relevant External Links for MIR5580 Gene

GeneLoc Exon Structure for
MIR5580
ECgene alternative splicing isoforms for
MIR5580

Expression for MIR5580 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5580 Gene:

MIR5580
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5580 Gene

Orthologs for MIR5580 Gene

Evolution for MIR5580 Gene

ENSEMBL:
Gene Tree for MIR5580 (if available)
TreeFam:
Gene Tree for MIR5580 (if available)

No data available for Orthologs for MIR5580 Gene

Paralogs for MIR5580 Gene

No data available for Paralogs for MIR5580 Gene

Variants for MIR5580 Gene

Sequence variations from dbSNP and Humsavar for MIR5580 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs121912766 Pathogenic 53,950,222(-) ACTGG(C/T)TGACC upstream-variant-2KB, reference, missense
rs121912768 Pathogenic 53,950,399(-) CCGAC(A/G)CCGGA upstream-variant-2KB, reference, missense
rs74054236 Likely benign 53,949,944(+) TGTGT(A/G)GGTGA upstream-variant-2KB, utr-variant-3-prime
rs76335800 Likely benign 53,949,884(+) TTTCC(A/T)TTTTT upstream-variant-2KB, utr-variant-3-prime
rs140085940 Uncertain significance 53,949,883(+) TTTTC(-/CT)TTTTT upstream-variant-2KB, utr-variant-3-prime

Relevant External Links for MIR5580 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5580

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5580 Gene

Disorders for MIR5580 Gene

Relevant External Links for MIR5580

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5580

No disorders were found for MIR5580 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5580 Gene

Publications for MIR5580 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR5580 Gene

Sources for MIR5580 Gene

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