Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR5580 Gene

Subcategory (RNA class) for MIR5580 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5580 Gene

  • MicroRNA 5580 2 3 5
  • Hsa-Mir-5580 3

External Ids for MIR5580 Gene

Previous GeneCards Identifiers for MIR5580 Gene

  • GC14U901303
  • GC14M054419

Summaries for MIR5580 Gene

Entrez Gene Summary for MIR5580 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5580 Gene

MIR5580 (MicroRNA 5580) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5580 Gene

Genomics for MIR5580 Gene

Regulatory Elements for MIR5580 Gene

Enhancers for MIR5580 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F053946 1 Ensembl ENCODE 0.8 +1.6 1585 1.7 SOX13 CTCF ESRRA SIN3A RARA E2F1 POLR2A ZNF652 TCF7L2 MAZ BMP4 MIR5580 ENSG00000231922
GH14F053950 1.3 VISTA ENCODE 0.4 -6.0 -6010 7.8 ATF1 MLX ARID4B FEZF1 ZNF48 ETS1 ZNF121 ELK1 PAF1 ZNF263 BMP4 MIR5580
GH14F053942 1.1 Ensembl ENCODE 0.4 +5.0 5043 1.6 MLX ARID4B THRB RAD21 RARA CREM MIXL1 THAP11 HMG20B CEBPA BMP4 MIR5580 ENSG00000231922
GH14F053927 0.9 Ensembl ENCODE 0.3 +21.0 21040 0.9 SOX13 SOX5 TEAD1 FOXA3 JUN TEAD3 CEBPA ZBTB33 HOMEZ BMP4 ENSG00000231922 MIR5580
GH14F053924 0.8 Ensembl ENCODE 0.3 +23.5 23467 1.3 JUN BHLHE40 CEBPB USF2 MAX FOS MAFK ENSG00000231922 MIR5580
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR5580 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5580 Gene

Chromosome:
14
Start:
53,948,427 bp from pter
End:
53,948,484 bp from pter
Size:
58 bases
Orientation:
Minus strand

Genomic View for MIR5580 Gene

Genes around MIR5580 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5580 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5580 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5580 Gene

ORGUL Member Location for MIR5580 Gene

ORGUL Member Location for MIR5580 gene

Proteins for MIR5580 Gene

Post-translational modifications for MIR5580 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5580 Gene

Domains & Families for MIR5580 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR5580 Gene

Function for MIR5580 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5580 Gene

Localization for MIR5580 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR5580 Gene

Pathways & Interactions for MIR5580 Gene

SuperPathways for MIR5580 Gene

No Data Available

Interacting Proteins for MIR5580 Gene

Gene Ontology (GO) - Biological Process for MIR5580 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR5580 Gene

Transcripts for MIR5580 Gene

mRNA/cDNA for MIR5580 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5580 Gene

No ASD Table

Relevant External Links for MIR5580 Gene

GeneLoc Exon Structure for
MIR5580
ECgene alternative splicing isoforms for
MIR5580

Expression for MIR5580 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR5580 Gene:

MIR5580
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5580 Gene

Orthologs for MIR5580 Gene

Evolution for MIR5580 Gene

ENSEMBL:
Gene Tree for MIR5580 (if available)
TreeFam:
Gene Tree for MIR5580 (if available)

No data available for Orthologs for MIR5580 Gene

Paralogs for MIR5580 Gene

No data available for Paralogs for MIR5580 Gene

Variants for MIR5580 Gene

Sequence variations from dbSNP and Humsavar for MIR5580 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs121912766 Pathogenic 53,950,222(-) ACTGG(C/T)TGACC upstream-variant-2KB, reference, missense
rs121912768 Pathogenic 53,950,399(-) CCGAC(A/G)CCGGA upstream-variant-2KB, reference, missense
rs112326559 -- 53,948,788(+) CTCGA(G/T)ATTTC upstream-variant-2KB
rs112898335 -- 53,950,305(+) ACATC(A/G)CTGAA upstream-variant-2KB, reference, synonymous-codon
rs113221162 -- 53,949,685(+) AAAGA(C/G)ATGAG downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR5580 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5580

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5580 Gene

Disorders for MIR5580 Gene

Relevant External Links for MIR5580

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5580

No disorders were found for MIR5580 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5580 Gene

Publications for MIR5580 Gene

  1. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) FriedlAonder M.R. … Rajewsky N. (Nucleic Acids Res. 2012) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR5580 Gene

Sources for MIR5580 Gene

Content
Loading form....