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Aliases for MIR5572 Gene

Subcategory (RNA class) for MIR5572 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR5572 Gene

  • MicroRNA 5572 2 3
  • ARNT2 4 5
  • Aryl Hydrocarbon Receptor Nuclear Translocator 2 5
  • Class E Basic Helix-Loop-Helix Protein 1 4
  • ARNT Protein 2 4
  • Hsa-Mir-5572 3
  • KIAA0307 4
  • BHLHe1 4

External Ids for MIR5572 Gene

Previous GeneCards Identifiers for MIR5572 Gene

  • GC15U901439
  • GC15P080876
  • GC15P080581

Summaries for MIR5572 Gene

Entrez Gene Summary for MIR5572 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5572 Gene

MIR5572 (MicroRNA 5572) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR5572 include Webb-Dattani Syndrome. An important paralog of this gene is ARNT.

UniProtKB/Swiss-Prot for MIR5572 Gene

  • Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR5572 Gene

Genomics for MIR5572 Gene

Regulatory Elements for MIR5572 Gene

Enhancers for MIR5572 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR5572 on UCSC Golden Path with GeneCards custom track

Promoters for MIR5572 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR5572 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR5572 Gene

Chromosome:
15
Start:
80,404,350 bp from pter
End:
80,597,937 bp from pter
Size:
193,588 bases
Orientation:
Plus strand

Genomic View for MIR5572 Gene

Genes around MIR5572 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5572 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5572 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5572 Gene

Proteins for MIR5572 Gene

  • Protein details for MIR5572 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBZ2-ARNT2_HUMAN
    Recommended name:
    Aryl hydrocarbon receptor nuclear translocator 2
    Protein Accession:
    Q9HBZ2
    Secondary Accessions:
    • B4DIS7
    • O15024
    • Q8IYC2

    Protein attributes for MIR5572 Gene

    Size:
    717 amino acids
    Molecular mass:
    78691 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3 (By similarity).
    • Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3 (By similarity).
    SequenceCaution:
    • Sequence=AAH36099.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA20766.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR5572 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR5572 Gene

Post-translational modifications for MIR5572 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR5572 Gene

No data available for DME Specific Peptides for MIR5572 Gene

Domains & Families for MIR5572 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HBZ2

UniProtKB/Swiss-Prot:

ARNT2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with MIR5572: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for MIR5572 Gene

Function for MIR5572 Gene

Molecular function for MIR5572 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function (PubMed:24022475). Specifically recognizes the xenobiotic response element (XRE).

Gene Ontology (GO) - Molecular Function for MIR5572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding ISS --
GO:0017162 aryl hydrocarbon receptor binding ISS --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with MIR5572: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5572 Gene

Localization for MIR5572 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR5572 Gene

Gene Ontology (GO) - Cellular Components for MIR5572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR5572: view

No data available for Subcellular locations from COMPARTMENTS for MIR5572 Gene

Pathways & Interactions for MIR5572 Gene

SuperPathways for MIR5572 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5572 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA --
GO:0001701 in utero embryonic development ISS --
GO:0006355 regulation of transcription, DNA-templated IDA --
GO:0007417 central nervous system development ISS --
GO:0007420 brain development IMP --
genes like me logo Genes that share ontologies with MIR5572: view

No data available for Pathways by source and SIGNOR curated interactions for MIR5572 Gene

Drugs & Compounds for MIR5572 Gene

No Compound Related Data Available

Transcripts for MIR5572 Gene

mRNA/cDNA for MIR5572 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5572 Gene

No ASD Table

Relevant External Links for MIR5572 Gene

GeneLoc Exon Structure for
MIR5572
ECgene alternative splicing isoforms for
MIR5572

Expression for MIR5572 Gene

mRNA expression in normal human tissues for MIR5572 Gene

mRNA differential expression in normal tissues according to GTEx for MIR5572 Gene

This gene is overexpressed in Testis (x14.7), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Liver (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR5572 Gene:

MIR5572
genes like me logo Genes that share expression patterns with MIR5572: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR5572 Gene

Orthologs for MIR5572 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR5572 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 97 (a)
OneToMany
ARNT2 35
  • 94 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ARNT2 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arnt2 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARNT2 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARNT2 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARNT2 35
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARNT2 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARNT2 35
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arnt2 35
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta tgo 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea aha-1 35
  • 48 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2012 35
  • 49 (a)
OneToMany
Species where no ortholog for MIR5572 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR5572 Gene

ENSEMBL:
Gene Tree for MIR5572 (if available)
TreeFam:
Gene Tree for MIR5572 (if available)

Paralogs for MIR5572 Gene

genes like me logo Genes that share paralogs with MIR5572: view

Variants for MIR5572 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR5572 Gene

Variant ID Type Subtype PubMed ID
nsv471685 CNV gain 15918152
nsv570235 CNV loss 21841781

Relevant External Links for MIR5572 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5572

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR5572 Gene

Disorders for MIR5572 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR5572 Gene - From: GeneCards

Disorder Aliases PubMed IDs
webb-dattani syndrome
  • hypothalamo-pituitary-frontotemporal hypoplasia with visual and renal anomalies
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ARNT2_HUMAN
  • Webb-Dattani syndrome (WEDAS) [MIM:615926]: A disorder characterized by postnatal microcephaly with fronto-temporal lobe hypoplasia, multiple pituitary hormone deficiency, global developmental delay, seizures, severe visual impairment and abnormalities of the kidneys and urinary tract. {ECO:0000269 PubMed:24022475}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR5572

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR5572
genes like me logo Genes that share disorders with MIR5572: view

No data available for Genatlas for MIR5572 Gene

Publications for MIR5572 Gene

  1. ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies. (PMID: 24022475) Webb E.A. … Dattani M.T. (Brain 2013) 4 65
  2. Deep sequencing of short RNAs reveals novel microRNAs in minor salivary glands of patients with SjAPgren's syndrome. (PMID: 21895886) Tandon M. … Alevizos I. (Oral Dis 2012) 3 65
  3. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 65
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 65
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 65

Products for MIR5572 Gene

Sources for MIR5572 Gene

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