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Aliases for MIR557 Gene

Subcategory (RNA class) for MIR557 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR557 Gene

  • MicroRNA 557 2 3
  • Hsa-Mir-557 3
  • MIRN557 3

External Ids for MIR557 Gene

ORGUL Members for MIR557 Gene

Previous HGNC Symbols for MIR557 Gene

  • MIRN557

Previous GeneCards Identifiers for MIR557 Gene

  • GC01P166612
  • GC01P168344

Summaries for MIR557 Gene

Entrez Gene Summary for MIR557 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR557 Gene

MIR557 (MicroRNA 557) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR557 Gene

Genomics for MIR557 Gene

Genomic Location for MIR557 Gene

Start:
168,375,524 bp from pter
End:
168,375,621 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR557 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR557 Gene

No data available for Regulatory Elements for MIR557 Gene

Proteins for MIR557 Gene

Post-translational modifications for MIR557 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR557 Gene

Domains for MIR557 Gene

Gene Families for MIR557 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR557: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR557 Gene

Function for MIR557 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR557 Gene

Localization for MIR557 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR557 Gene

Pathways for MIR557 Gene

SuperPathways for MIR557 Gene

No Data Available

Interacting Proteins for MIR557 Gene

Gene Ontology (GO) - Biological Process for MIR557 Gene

None

No data available for Pathways by source for MIR557 Gene

Transcripts for MIR557 Gene

mRNA/cDNA for MIR557 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR557 Gene

No ASD Table

Relevant External Links for MIR557 Gene

GeneLoc Exon Structure for
MIR557
ECgene alternative splicing isoforms for
MIR557

Expression for MIR557 Gene

mRNA expression in normal human tissues for MIR557 Gene

genes like me logo Genes that share expressions with MIR557: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR557 Gene

Orthologs for MIR557 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR557 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-557 36
  • 99 (a)
OneToOne
Species with no ortholog for MIR557:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR557 Gene

ENSEMBL:
Gene Tree for MIR557 (if available)
TreeFam:
Gene Tree for MIR557 (if available)

Paralogs for MIR557 Gene

No data available for Paralogs for MIR557 Gene

Variants for MIR557 Gene

Sequence variations from dbSNP and Humsavar for MIR557 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5778574 -- 168,374,385(+) TTTTA(-/G)TGCCC upstream-variant-2KB
rs7544450 -- 168,376,107(+) AATGC(C/T)TAGAG downstream-variant-500B
rs7549939 -- 168,374,197(+) ATGTG(C/T)GCTGA upstream-variant-2KB
rs10753773 -- 168,374,111(+) CAGAG(A/C)CCAAA upstream-variant-2KB
rs34011759 -- 168,373,961(+) ATTTT(-/A)AAAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR557 Gene

Variant ID Type Subtype PubMed ID
nsv831825 CNV Gain+Loss 17160897
nsv872527 CNV Loss 21882294
dgv404n71 CNV Loss 21882294

Relevant External Links for MIR557 Gene

HapMap Linkage Disequilibrium report
MIR557

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR557 Gene

Disorders for MIR557 Gene

No disorders were found for MIR557 Gene.

No data available for UniProtKB/Swiss-Prot for MIR557 Gene

Publications for MIR557 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3

Products for MIR557 Gene

Sources for MIR557 Gene

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