Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR557 Gene

Subcategory (RNA class) for MIR557 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR557 Gene

  • MicroRNA 557 2 3 5
  • Hsa-Mir-557 3
  • MIRN557 3

External Ids for MIR557 Gene

ORGUL Members for MIR557 Gene

Previous HGNC Symbols for MIR557 Gene

  • MIRN557

Previous GeneCards Identifiers for MIR557 Gene

  • GC01P166612
  • GC01P168344

Summaries for MIR557 Gene

Entrez Gene Summary for MIR557 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR557 Gene

MIR557 (MicroRNA 557) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR557 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR557 Gene

Genomics for MIR557 Gene

GeneHancer (GH) Regulatory Elements for MIR557 Gene

Promoters and enhancers for MIR557 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I168342 Enhancer 1.3 Ensembl ENCODE dbSUPER 11 -32.4 -32414 1.4 HDAC1 ELF3 ATF1 RB1 RAD21 RFX5 ARID2 EGR1 ZNF143 RCOR1 MIR557 LOC101928596 ATP1B1 GC01M168356 LOC441914 GC01M168113
GH01I168347 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.9 -27.1 -27068 1.1 HDAC1 ZNF146 IRF2 PKNOX1 TAF9B SAP130 NFATC3 ARNT ZMYM3 ZBTB40 MIR557 GC01M168356 LOC441914 GC01M168113
GH01I168398 Enhancer 1.1 FANTOM5 ENCODE 11.7 +23.7 23744 1 HDAC1 ARNT ZSCAN4 BMI1 TCF12 ZNF366 FOS ATF7 SMARCC1 RFX3 GC01M168113 MIR557 ATP1B1 LOC101928596 TBX19 ENSG00000283255
GH01I168407 Enhancer 1.1 Ensembl ENCODE 11.5 +33.5 33514 3 ATF1 KLF17 BMI1 FEZF1 BATF ZBTB40 ZNF335 ZNF366 ATF7 FOS ENSG00000283255 MIR557 TBX19 LOC101928596 ATP1B1 RCSD1 GPR161 LOC100505918 ENSG00000228697
GH01I168300 Enhancer 0.9 Ensembl ENCODE 10.9 -73.8 -73761 2.6 MXI1 JUN MAX SIN3A RAD21 BRCA1 RFX5 NFYB SMARCC2 RCOR1 TBX19 MIR557 SFT2D2 LOC441914 GC01M168113
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR557 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR557 Gene

Genomic Locations for MIR557 Gene
chr1:168,375,524-168,375,621
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr1:168,344,762-168,344,859
(GRCh37/hg19)

Genomic View for MIR557 Gene

Genes around MIR557 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR557 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR557 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR557 Gene

Proteins for MIR557 Gene

Post-translational modifications for MIR557 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR557 Gene

Domains & Families for MIR557 Gene

Gene Families for MIR557 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR557: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR557 Gene

Function for MIR557 Gene

Phenotypes From GWAS Catalog for MIR557 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR557 Gene

Localization for MIR557 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR557 Gene

Pathways & Interactions for MIR557 Gene

SuperPathways for MIR557 Gene

No Data Available

Interacting Proteins for MIR557 Gene

Gene Ontology (GO) - Biological Process for MIR557 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR557 Gene

Drugs & Compounds for MIR557 Gene

No Compound Related Data Available

Transcripts for MIR557 Gene

mRNA/cDNA for MIR557 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR557 Gene

No ASD Table

Relevant External Links for MIR557 Gene

GeneLoc Exon Structure for
MIR557
ECgene alternative splicing isoforms for
MIR557

Expression for MIR557 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR557 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR557 Gene:

MIR557
genes like me logo Genes that share expression patterns with MIR557: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR557 Gene

Orthologs for MIR557 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR557 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-557 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR557 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR557 Gene

ENSEMBL:
Gene Tree for MIR557 (if available)
TreeFam:
Gene Tree for MIR557 (if available)

Paralogs for MIR557 Gene

No data available for Paralogs for MIR557 Gene

Variants for MIR557 Gene

Sequence variations from dbSNP and Humsavar for MIR557 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000175663 -- 168,374,205(+) C/A/T upstream_transcript_variant
rs1000249278 -- 168,373,975(+) A/C upstream_transcript_variant
rs1001181781 -- 168,375,958(+) T/C downstream_transcript_variant
rs1004487233 -- 168,373,724(+) G/A/T upstream_transcript_variant
rs1005412646 -- 168,375,582(+) G/C non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR557 Gene

Variant ID Type Subtype PubMed ID
nsv1002007 CNV gain 25217958
nsv1013200 CNV gain 25217958
nsv1078878 OTHER inversion 25765185
nsv831825 CNV gain+loss 17160897

Additional Variant Information for MIR557 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR557

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR557 Gene

Disorders for MIR557 Gene

Additional Disease Information for MIR557

No disorders were found for MIR557 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR557 Gene

Publications for MIR557 Gene

  1. MiR-557 works as a tumor suppressor in human lung cancers by negatively regulating LEF1 expression. (PMID: 28639890) Qiu J … Mao Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58

Products for MIR557 Gene

Sources for MIR557 Gene

Content
Loading form....