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Aliases for MIR556 Gene

Subcategory (RNA class) for MIR556 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR556 Gene

  • MicroRNA 556 2 3 5
  • Hsa-Mir-556 3
  • Mir-556 3
  • MIRN556 3

External Ids for MIR556 Gene

ORGUL Members for MIR556 Gene

Previous HGNC Symbols for MIR556 Gene

  • MIRN556

Previous GeneCards Identifiers for MIR556 Gene

  • GC01P160579

Summaries for MIR556 Gene

Entrez Gene Summary for MIR556 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR556 Gene

MIR556 (MicroRNA 556) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR556 Gene

Genomics for MIR556 Gene

Regulatory Elements for MIR556 Gene

Enhancers for MIR556 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F162388 1.1 Ensembl ENCODE 10.8 +46.8 46772 2.6 RAD21 YY1 GATA2 ETV6 CREM EGR2 SMARCA5 REST NR2F2 MBD2 MIR556 RGS4 SPATA46 SH2D1B
GH01F162065 0.7 ENCODE 10.1 -276.9 -276921 0.2 CTCF ZNF362 SAP130 ZNF384 RAD21 ZFP69B ZFHX2 ZNF366 ZNF692 ETV4 SH2D1B MIR556 C1orf226 SPATA46 NOS1AP ENSG00000227818
GH01F162028 0.6 FANTOM5 9.5 -313.7 -313693 0.4 FOS SPI1 RELA MIR556 C1orf226 SPATA46 ATF6 GC01P162033 OLFML2B
GH01F162066 0.4 Ensembl 10.1 -277.2 -277246 0.2 ZFHX2 ZNF366 SH2D1B MIR556 C1orf226 SPATA46 NOS1AP ENSG00000227818
GH01F162026 0.3 FANTOM5 9.5 -315.5 -315522 0.3 MIR556 C1orf226 SPATA46 ATF6 OLFML2B GC01P162033
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR556 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR556 Gene

Chromosome:
1
Start:
162,342,546 bp from pter
End:
162,342,640 bp from pter
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR556 Gene

Genes around MIR556 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR556 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR556 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR556 Gene

Proteins for MIR556 Gene

Post-translational modifications for MIR556 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR556 Gene

Domains & Families for MIR556 Gene

Gene Families for MIR556 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR556: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR556 Gene

Function for MIR556 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR556 Gene

Localization for MIR556 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR556 Gene

Pathways & Interactions for MIR556 Gene

SuperPathways for MIR556 Gene

No Data Available

Interacting Proteins for MIR556 Gene

Gene Ontology (GO) - Biological Process for MIR556 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR556 Gene

Transcripts for MIR556 Gene

mRNA/cDNA for MIR556 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR556 Gene

No ASD Table

Relevant External Links for MIR556 Gene

GeneLoc Exon Structure for
MIR556
ECgene alternative splicing isoforms for
MIR556

Expression for MIR556 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR556 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR556 Gene:

MIR556
genes like me logo Genes that share expression patterns with MIR556: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR556 Gene

Orthologs for MIR556 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR556 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-556 35
  • 100 (a)
OneToOne
Species where no ortholog for MIR556 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR556 Gene

ENSEMBL:
Gene Tree for MIR556 (if available)
TreeFam:
Gene Tree for MIR556 (if available)

Paralogs for MIR556 Gene

No data available for Paralogs for MIR556 Gene

Variants for MIR556 Gene

Sequence variations from dbSNP and Humsavar for MIR556 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112023593 -- 162,342,194(+) CTTAT(C/T)TCCCA intron-variant, upstream-variant-2KB
rs112918981 -- 162,341,486(+) CATAT(A/C)ATTTG intron-variant, upstream-variant-2KB
rs113630733 -- 162,342,685(+) GTAAT(A/G/T)TAATA intron-variant, downstream-variant-500B
rs114488722 -- 162,342,657(+) ACTTA(C/T)CAAAA intron-variant, downstream-variant-500B
rs114496757 -- 162,341,775(+) AGTTT(C/T)GGATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR556 Gene

Variant ID Type Subtype PubMed ID
esv2758973 CNV gain 17122850
esv34209 CNV gain 17911159
esv3587740 CNV gain 21293372
nsv516482 CNV gain+loss 19592680
nsv818511 CNV gain 17921354

Relevant External Links for MIR556 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR556

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR556 Gene

Disorders for MIR556 Gene

Relevant External Links for MIR556

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR556

No disorders were found for MIR556 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR556 Gene

Publications for MIR556 Gene

  1. Upregulation of miR-556-5p promoted prostate cancer cell proliferation by suppressing PPP2R2A expression. (PMID: 26297546) Zhao W. … Men T. (Biomed. Pharmacother. 2015) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR556 Gene

Sources for MIR556 Gene

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