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Aliases for MIR555 Gene

Subcategory (RNA class) for MIR555 Gene


Quality Score for this RNA gene is


Aliases for MIR555 Gene

  • MicroRNA 555 2 3
  • EC 4 61
  • ASH1L 4 5
  • Absent Small And Homeotic Disks Protein 1 Homolog 4
  • ASH1 Like Histone Lysine Methyltransferase 5
  • Lysine N-Methyltransferase 2H 4
  • ASH1-Like Protein 4
  • Hsa-Mir-555 3
  • KIAA1420 4
  • MIRN555 3
  • HuASH1 4
  • KMT2H 4

External Ids for MIR555 Gene

Previous HGNC Symbols for MIR555 Gene

  • MIRN555

Previous GeneCards Identifiers for MIR555 Gene

  • GC01M153584
  • GC01M155316
  • GC01M155347

Summaries for MIR555 Gene

Entrez Gene Summary for MIR555 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR555 Gene

MIR555 (MicroRNA 555) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Chromatin organization and PKMTs methylate histone lysines. An important paralog of this gene is SETD2.

UniProtKB/Swiss-Prot for MIR555 Gene

  • Histone methyltransferase specifically methylating Lys-36 of histone H3 (H3K36me).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR555 Gene

Genomics for MIR555 Gene

Regulatory Elements for MIR555 Gene

Enhancers for MIR555 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155598 1.4 FANTOM5 Ensembl ENCODE 11.6 -36.7 -36687 1.8 ATF1 PTRF RAD21 ZNF263 CEBPB MEF2D CREB3 ZNF585B IKZF1 ZBTB33 PYGO2 ASH1L LOC101928120 MIR555 ASH1L-AS1 RUSC1 RUSC1-AS1 RNU6-1297P FDPS MSTO2P
GH01F155650 1.5 FANTOM5 Ensembl ENCODE 10.4 -88.8 -88789 2.3 TBP INSM2 SIN3A ZNF366 SCRT2 FOS ZNF362 ZNF680 SP3 CEBPB KRTCAP2 KIAA0907 THBS3 ENSG00000271267 DCST1 SSR2 SCAMP3 FAM189B MIR555 ASH1L
GH01F155499 1.3 FANTOM5 Ensembl ENCODE 11.3 +62.5 62483 2.2 YY2 INSM2 CHD7 ZEB2 OSR2 ZNF366 ZBTB48 CEBPA ZNF580 PRDM10 MIR555 ASH1L RNU6-1297P RUSC1 RUSC1-AS1 FDPS ARHGEF2 RIT1 MTX1 YY1AP1
GH01F155307 1.2 ENCODE 11 +253.7 253707 3.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 KIAA0907 LOC101928120 GBA MSTO2P ASH1L-AS1 HCN3 THBS3 ENSG00000271267 DAP3P1 MIR4258
GH01F155242 1.2 ENCODE 10.1 +318.6 318565 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR555 on UCSC Golden Path with GeneCards custom track

Promoters for MIR555 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR555 Gene

155,335,268 bp from pter
155,562,807 bp from pter
227,540 bases
Minus strand

Genomic View for MIR555 Gene

Genes around MIR555 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR555 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR555 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR555 Gene

Proteins for MIR555 Gene

  • Protein details for MIR555 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone-lysine N-methyltransferase ASH1L
    Protein Accession:
    Secondary Accessions:
    • Q59GP1
    • Q5T714
    • Q5T715
    • Q9P2C7

    Protein attributes for MIR555 Gene

    2969 amino acids
    Molecular mass:
    332790 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR555 Gene

    Alternative splice isoforms for MIR555 Gene


neXtProt entry for MIR555 Gene

Selected DME Specific Peptides for MIR555 Gene


Post-translational modifications for MIR555 Gene

  • Ubiquitination at Lys 402 and Lys 406
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR555 Gene

Domains & Families for MIR555 Gene

Gene Families for MIR555 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 A.T hook DNA-binding domains.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
  • Contains 1 PHD-type zinc finger.
  • Contains 3 A.T hook DNA-binding domains.
  • Contains 1 AWS domain.
  • Contains 1 BAH domain.
  • Contains 1 bromo domain.
  • Contains 1 post-SET domain.
  • Contains 1 SET domain.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with MIR555: view

No data available for Suggested Antigen Peptide Sequences for MIR555 Gene

Function for MIR555 Gene

Molecular function for MIR555 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase specifically methylating Lys-36 of histone H3 (H3K36me).

Enzyme Numbers (IUBMB) for MIR555 Gene

Gene Ontology (GO) - Molecular Function for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MIR555: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR555 Gene

Localization for MIR555 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR555 Gene

Nucleus. Cell junction, tight junction. Chromosome. Note=The relevance of tight junction localization is however unclear.

Gene Ontology (GO) - Cellular Components for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with MIR555: view

No data available for Subcellular locations from COMPARTMENTS for MIR555 Gene

Pathways & Interactions for MIR555 Gene

genes like me logo Genes that share pathways with MIR555: view

Pathways by source for MIR555 Gene

1 BioSystems pathway for MIR555 Gene

Gene Ontology (GO) - Biological Process for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0007267 cell-cell signaling TAS --
genes like me logo Genes that share ontologies with MIR555: view

No data available for SIGNOR curated interactions for MIR555 Gene

Transcripts for MIR555 Gene

mRNA/cDNA for MIR555 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR555 Gene

No ASD Table

Relevant External Links for MIR555 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR555 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR555 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR555 Gene:


mRNA Expression by UniProt/SwissProt for MIR555 Gene:

Tissue specificity: Widely expressed, with highest level in brain, heart and kidney.
genes like me logo Genes that share expression patterns with MIR555: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR555 Gene

Orthologs for MIR555 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR555 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ASH1L 35
  • 100 (a)
(Bos Taurus)
Mammalia ASH1L 35
  • 96 (a)
(Canis familiaris)
Mammalia ASH1L 35
  • 94 (a)
(Mus musculus)
Mammalia Ash1l 35
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ASH1L 35
  • 91 (a)
(Monodelphis domestica)
Mammalia ASH1L 35
  • 89 (a)
(Gallus gallus)
Aves ASH1L 35
  • 80 (a)
(Anolis carolinensis)
Reptilia ASH1L 35
  • 72 (a)
(Danio rerio)
Actinopterygii ash1l 35
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta ash1 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea set-25 35
  • 17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BYE1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
Species where no ortholog for MIR555 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR555 Gene

Gene Tree for MIR555 (if available)
Gene Tree for MIR555 (if available)

Paralogs for MIR555 Gene

genes like me logo Genes that share paralogs with MIR555: view

Variants for MIR555 Gene

Sequence variations from dbSNP and Humsavar for MIR555 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157264 -- 155,347,320(+) gagga(C/T)tgctt intron-variant, upstream-variant-2KB
rs111890635 -- 155,347,631(+) CAAGC(C/T)TCTGC intron-variant, upstream-variant-2KB
rs113306711 -- 155,346,423(+) GGTAG(C/T)GCTCC nc-transcript-variant, reference, missense
rs12562734 -- 155,347,152(+) CCAAC(A/G)CTCTG intron-variant, upstream-variant-2KB
rs138122556 -- 155,347,861(+) GTAGA(C/T)GACAA upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR555 Gene

Variant ID Type Subtype PubMed ID
nsv831636 CNV loss 17160897
esv33869 CNV loss 17666407

Relevant External Links for MIR555 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR555 Gene

Disorders for MIR555 Gene

Relevant External Links for MIR555

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR555 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR555 Gene

Publications for MIR555 Gene

  1. MicroRNA-555 has potent antiviral properties against poliovirus. (PMID: 26683768) Shim B.S. … Tripp R.A. (J. Gen. Virol. 2016) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 4 64
  4. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 64
  5. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. (PMID: 21239497) An S. … Song J.J. (J. Biol. Chem. 2011) 4 64

Products for MIR555 Gene

Sources for MIR555 Gene

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