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Aliases for MIR555 Gene

Subcategory (RNA class) for MIR555 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR555 Gene

  • MicroRNA 555 2 3
  • EC 2.1.1.43 4 61
  • ASH1L 4 5
  • Absent Small And Homeotic Disks Protein 1 Homolog 4
  • ASH1 Like Histone Lysine Methyltransferase 5
  • Lysine N-Methyltransferase 2H 4
  • ASH1-Like Protein 4
  • Hsa-Mir-555 3
  • KIAA1420 4
  • MIRN555 3
  • HuASH1 4
  • KMT2H 4

External Ids for MIR555 Gene

Previous HGNC Symbols for MIR555 Gene

  • MIRN555

Previous GeneCards Identifiers for MIR555 Gene

  • GC01M153584
  • GC01M155316
  • GC01M155347

Summaries for MIR555 Gene

Entrez Gene Summary for MIR555 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR555 Gene

MIR555 (MicroRNA 555) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is SETD2.

UniProtKB/Swiss-Prot for MIR555 Gene

  • Histone methyltransferase specifically methylating Lys-36 of histone H3 (H3K36me).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR555 Gene

Genomics for MIR555 Gene

Regulatory Elements for MIR555 Gene

Enhancers for MIR555 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR555 on UCSC Golden Path with GeneCards custom track

Promoters for MIR555 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR555 Gene

Chromosome:
1
Start:
155,335,268 bp from pter
End:
155,562,807 bp from pter
Size:
227,540 bases
Orientation:
Minus strand

Genomic View for MIR555 Gene

Genes around MIR555 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR555 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR555 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR555 Gene

ORGUL Member Location for MIR555 Gene

ORGUL Member Location for MIR555 gene

Proteins for MIR555 Gene

  • Protein details for MIR555 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NR48-ASH1L_HUMAN
    Recommended name:
    Histone-lysine N-methyltransferase ASH1L
    Protein Accession:
    Q9NR48
    Secondary Accessions:
    • Q59GP1
    • Q5T714
    • Q5T715
    • Q9P2C7

    Protein attributes for MIR555 Gene

    Size:
    2969 amino acids
    Molecular mass:
    332790 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92658.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR555 Gene

    Alternative splice isoforms for MIR555 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR555 Gene

Selected DME Specific Peptides for MIR555 Gene

Post-translational modifications for MIR555 Gene

  • Ubiquitination at Lys 402 and Lys 406
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR555 Gene

Domains & Families for MIR555 Gene

Gene Families for MIR555 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NR48

UniProtKB/Swiss-Prot:

ASH1L_HUMAN :
  • Contains 3 A.T hook DNA-binding domains.
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
  • Contains 1 PHD-type zinc finger.
Domain:
  • Contains 3 A.T hook DNA-binding domains.
  • Contains 1 AWS domain.
  • Contains 1 BAH domain.
  • Contains 1 bromo domain.
  • Contains 1 post-SET domain.
  • Contains 1 SET domain.
Family:
  • Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
Similarity:
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with MIR555: view

No data available for Suggested Antigen Peptide Sequences for MIR555 Gene

Function for MIR555 Gene

Molecular function for MIR555 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
UniProtKB/Swiss-Prot Function:
Histone methyltransferase specifically methylating Lys-36 of histone H3 (H3K36me).

Enzyme Numbers (IUBMB) for MIR555 Gene

Gene Ontology (GO) - Molecular Function for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0042800 histone methyltransferase activity (H3-K4 specific) IEA --
GO:0046975 histone methyltransferase activity (H3-K36 specific) IDA --
genes like me logo Genes that share ontologies with MIR555: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR555 Gene

Localization for MIR555 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR555 Gene

Nucleus. Cell junction, tight junction. Chromosome. Note=The relevance of tight junction localization is however unclear.

Gene Ontology (GO) - Cellular Components for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with MIR555: view

No data available for Subcellular locations from COMPARTMENTS for MIR555 Gene

Pathways & Interactions for MIR555 Gene

SuperPathways for MIR555 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR555 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006323 DNA packaging TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0007267 cell-cell signaling TAS --
GO:0032635 interleukin-6 production IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with MIR555: view

No data available for Pathways by source and SIGNOR curated interactions for MIR555 Gene

Drugs & Compounds for MIR555 Gene

No Compound Related Data Available

Transcripts for MIR555 Gene

mRNA/cDNA for MIR555 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR555 Gene

No ASD Table

Relevant External Links for MIR555 Gene

GeneLoc Exon Structure for
MIR555
ECgene alternative splicing isoforms for
MIR555

Expression for MIR555 Gene

mRNA expression in normal human tissues for MIR555 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR555 Gene:

MIR555

mRNA Expression by UniProt/SwissProt for MIR555 Gene:

Q9NR48-ASH1L_HUMAN
Tissue specificity: Widely expressed, with highest level in brain, heart and kidney.
genes like me logo Genes that share expression patterns with MIR555: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR555 Gene

Orthologs for MIR555 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR555 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ASH1L 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ASH1L 35
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ASH1L 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ash1l 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ASH1L 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ASH1L 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ASH1L 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ASH1L 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ash1l 35
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ash1 35
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea set-25 35
  • 17 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BYE1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for MIR555 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR555 Gene

ENSEMBL:
Gene Tree for MIR555 (if available)
TreeFam:
Gene Tree for MIR555 (if available)

Paralogs for MIR555 Gene

genes like me logo Genes that share paralogs with MIR555: view

Variants for MIR555 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR555 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV loss 17666407
nsv831636 CNV loss 17160897

Relevant External Links for MIR555 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR555

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR555 Gene

Disorders for MIR555 Gene

Relevant External Links for MIR555

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR555

No disorders were found for MIR555 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR555 Gene

Publications for MIR555 Gene

  1. MicroRNA-555 has potent antiviral properties against poliovirus. (PMID: 26683768) Shim B.S. … Tripp R.A. (J. Gen. Virol. 2016) 3 65
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  3. Histone recognition and large-scale structural analysis of the human bromodomain family. (PMID: 22464331) Filippakopoulos P. … Knapp S. (Cell 2012) 4 65
  4. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 4 65
  5. Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism. (PMID: 21239497) An S. … Song J.J. (J. Biol. Chem. 2011) 4 65

Products for MIR555 Gene

Sources for MIR555 Gene

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